| S&B Management Ltd | Real estate | 2011 |
| S&R Coachworks Limited | Wholesale & retail | 2019 |
| S&S Woodford Properties Ltd | Real estate | 2023 |
| S&Y Project Management Ltd | Construction | 2003 |
| S. Mitchell & Sons Limited | Administrative & support | 2025 |
| S.B.P Contracts Ltd | Construction | 2015 |
| S.E.A Installations Ltd | Construction | 2019 |
| S.E.T Car Servicing and MOT Centre Ltd | Wholesale & retail | 2020 |
| S.E.T Remapping Limited | Wholesale & retail | 2015 |
| S.G Building Solutions Ltd | Construction | 2026 |
| S.Quack Limited | Hospitality | 2025 |
| S.T.L.Lilac Property Management Co Ltd | Households | 2019 |
| S2K Distribution Ltd | Wholesale & retail | 2025 |
| SA Partum Ltd | Professional & scientific | 2021 |
| SA Toor Construction Ltd | Construction | 2022 |
| Saanjh Boutique Ltd | Wholesale & retail | 2024 |
| Saars Distribution Ltd | Extraterritorial | 2022 |
| Saay Consultancy Ltd | Professional & scientific | 2023 |
| SAB Equine Limited | Agriculture & fishing | 2024 |
| Sable IO Ltd | Information & communication | 2017 |
| Sabresaurus Ltd | Information & communication | 2014 |
| Sabrina Daniels Permanent Cosmetics Ltd | Other services | 2022 |
| SAC Trans Ltd | Transport & logistics | 2024 |
| Safe Decision Ltd | Administrative & support | 2019 |
| Safe Haven Parenting Assessment Unit Ltd | Health & social care | 2024 |
| Safe Home Security Systems Ltd | Other services | 2022 |
| Safemind Health Ltd | Public administration | 2025 |
| Safety Bay Marina Ltd | Real estate | 2018 |
| Safety Mind Limited | Professional & scientific | 2021 |
| Safetytech Services Ltd | Public administration | 2020 |
| Saffron of Punjab Ltd | Hospitality | 2024 |
| Saffron Software Solutions Ltd | Information & communication | 2023 |
| Safhire Travel Limited | Transport & logistics | 2015 |
| Saga DC Ltd | Information & communication | 2021 |
| Sagemi Limited | Transport & logistics | 2025 |
| Sager's Jewellery Limited | Wholesale & retail | 2013 |
| Sagis Facilities Services Limited | Professional & scientific | 2025 |
| Saglam Group Limited | Financial services | 2020 |
| Sahajo Limited | Real estate | 2026 |
| Sahej Logistics Limited | Transport & logistics | 2025 |
| Sahi UK Transport Limited | Transport & logistics | 2025 |
| Sahib Sarai Holdings Ltd | Financial services | 2025 |
| Sahota Brothers Construct Limited | Construction | 2017 |
| Sahota Builders Limited | Construction | 2025 |
| Sahota Estates Holdings Ltd | Real estate | 2025 |
| SAI Hire Limited | Construction | 2022 |
| Saint Veloan Ltd | Wholesale & retail | 2026 |
| Saintfemi Limited | Manufacturing | 2010 |
| Sajabb Limited | Wholesale & retail | 2026 |
| Sajjhost Ltd | Wholesale & retail | 2025 |
| SAK Construction Holdings Limited | Financial services | 2026 |
| SAK Construction Limited | Construction | 2006 |
| Sakl Ltd | Wholesale & retail | 2022 |
| Salem Place Management Company Limited | Households | 1991 |
| Salikill Pest Control Ltd | Administrative & support | 2025 |
| Sall Estate Agents Ltd | Real estate | 2019 |
| Salon Angie Limited | Other services | 2011 |
| Saltpond Properties Limited | Real estate | 2025 |
| Saltpond Ventures Limited | Hospitality | 2025 |
| Salty Potato Limited | Administrative & support | 2012 |
| Salty Sonic Limited | Professional & scientific | 2024 |
| Saluja Estates Ltd | Real estate | 2022 |
| Salus Securities Limited | Administrative & support | 2024 |
| SAM Young Consultancy Limited | Administrative & support | 2017 |
| Sambeul UK Limited | Administrative & support | 2017 |
| Sameday Route Logistics Limited | Transport & logistics | 2026 |
| Samfriki Ltd | Transport & logistics | 2020 |
| Sami's Bakery Limited | Hospitality | 2024 |
| Sammy Drylining Ltd | Construction | 2018 |
| Sammy K Services Ltd | Transport & logistics | 2025 |
| Samnate Engineering Ltd | Professional & scientific | 2022 |
| Samona Impex Ltd | Wholesale & retail | 2023 |
| Sampmor Ltd | Transport & logistics | 2016 |
| Samra Property SE Ltd | Real estate | 2024 |
| Samskriti Foods Ltd | Wholesale & retail | 2022 |
| Samuel Festus Brown Ltd | Health & social care | 2025 |
| Sana Property Investments Ltd | Real estate | 2024 |
| Sanbal Assets Ltd | Real estate | 2021 |
| Sandavid Construction Limited | Construction | 2025 |
| Sandeep Doaba Punjabi Catering Service Ltd | Hospitality | 2023 |
| Sandhu Brothers Real Estate Limited | Real estate | 2021 |
| Sandling Park (Maidstone) Management Limited | Households | 2005 |
| Sands Trans Ltd | Transport & logistics | 2018 |
| Sangha Wealth Investments Ltd | Financial services | 2024 |
| Sanghera & Sons Estates Limited | Real estate | 2024 |
| Sanjivani Healthcare Limited | Wholesale & retail | 2024 |
| SAP Source Solutions Limited | Information & communication | 2019 |
| Sapegenic Connect Ltd | Administrative & support | 2022 |
| Sapphire Consult Ltd | Professional & scientific | 2020 |
| Sapphire Falls Events Ltd | Other services | 2026 |
| Sapphire Properties Services Limited | Real estate | 2019 |
| Sapphire Swim School Ltd | Arts & recreation | 2023 |
| Sapphire Taxi Limited | Transport & logistics | 2022 |
| Sara Services Ltd | Administrative & support | 2018 |
| Sarah Carer Limited | Health & social care | 2025 |
| Sarah Hutchinson Ltd | Other services | 2022 |
| Sarahjaynefrancisbusiness Ltd | Wholesale & retail | 2025 |
| Sarai Services Limited | Extraterritorial | 2024 |
| Sarascott UK Limited | Wholesale & retail | 2011 |
| Sarathi Ventures Limited | Hospitality | 2023 |