| Seprop Ltd. | Hospitality | 2013 |
| Serena Estates Limited | Financial services | 2015 |
| Serena's Tuition Rochester Ltd. | Education | 2025 |
| Serenity Beauty Rooms Ltd | Other services | 2022 |
| Serenity Hair & Beauty Spa Kent Limited | Other services | 2016 |
| Serenity Nail Spa Limited | Other services | 2016 |
| Serenity Wellness Homes Ltd | Health & social care | 2025 |
| Serenityway Ltd | Administrative & support | 2022 |
| SERGIO77 Transport Limited | Transport & logistics | 2015 |
| Sergiu Constantin Ltd | Transport & logistics | 2019 |
| Sergiu Sergiu Limited | Transport & logistics | 2025 |
| Sergiu Speed Limited | Transport & logistics | 2017 |
| Series 10 Limited | Construction | 1990 |
| Serlexconcepts Ltd | Health & social care | 2019 |
| Sero Kent Limited | Hospitality | 2026 |
| Serviceinaction Ltd | Professional & scientific | 2023 |
| Sesay Ltd | Health & social care | 2025 |
| Setpoint Systems Ltd | Information & communication | 2026 |
| Settle Right UK Ltd | Professional & scientific | 2026 |
| Seven 7 Football Coaching Ltd | Arts & recreation | 2024 |
| Sewaa Ltd | Other services | 2022 |
| Seymour Electrical Services Ltd | Construction | 2015 |
| Sezy Ltd | Hospitality | 2015 |
| SFA Trans Ltd | Transport & logistics | 2018 |
| Sfaestheticsbeauty Ltd | Other services | 2023 |
| SFM Haulier Ltd | Transport & logistics | 2026 |
| SFS Associates Limited | Hospitality | 2025 |
| SFS Direct Ltd | Other services | 2025 |
| SG Building Services Ltd | Construction | 2025 |
| SG Cleaning Services Ltd | Other services | 2025 |
| SGB Maintenance Ltd | Other services | 2023 |
| SGD TRS Ltd | Transport & logistics | 2019 |
| SH Scaffolding (UK) Ltd | Construction | 2013 |
| Shabana Shop Limited | Wholesale & retail | 2024 |
| Shabnam Bashir Ltd | Professional & scientific | 2021 |
| Shabrix Ltd | Wholesale & retail | 2025 |
| Shaby Hair Ltd | Extraterritorial | 2023 |
| Shadowtop Limited | Real estate | 1987 |
| Shaf Ltd | Financial services | 2021 |
| Shah Jalal Masjid Limited | Other services | 2017 |
| Shaheena Qureshi Estate Ltd | Real estate | 2020 |
| Shain Kabba Limited | Real estate | 2021 |
| Shajan Limited | Real estate | 2018 |
| Shakes and Bakes Ltd | Hospitality | 2026 |
| Shaley UK Limited | Health & social care | 2016 |
| Shalom Kiddies Limited | Health & social care | 2022 |
| Shalom Property Group Ltd | Real estate | 2025 |
| Shalomcare & Home Ltd | Health & social care | 2024 |
| Shanker Investments Limited | Real estate | 2025 |
| Shapers (Gravesend) Limited | Arts & recreation | 2014 |
| Sharp Building Solutions Ltd | Construction | 2025 |
| Sharp Edge London Limited | Wholesale & retail | 2025 |
| Shaun Martin Carpentry Ltd | Construction | 2014 |
| Shayler Estates Ltd | Real estate | 2023 |
| Sheekwas Ltd | Health & social care | 2014 |
| Sheen Support Services Ltd | Administrative & support | 2018 |
| Shefford Consultancy Ltd | Professional & scientific | 2020 |
| Shelby Property Services Ltd | Extraterritorial | 2024 |
| Sheldon Heights Management Ltd | Households | 2014 |
| Shelender Singh Ltd | Real estate | 2016 |
| Shen's Healthcare Services Limited | Hospitality | 2023 |
| Shepley Innovations LLP | | 2025 |
| Shere Punjab of Gravesend Ltd | Hospitality | 2016 |
| Shergill Food & Wine Limited | Wholesale & retail | 2014 |
| Shergill Investment Group Ltd | Real estate | 2025 |
| Shermarketplaceltd Limited | Wholesale & retail | 2025 |
| Sherwood Construction Consultant Services Limited | Professional & scientific | 2009 |
| Shetra Holdings Limited | Financial services | 2013 |
| Shindo Consultancy Limited | Information & communication | 2010 |
| Shindo Properties & Lettings Ltd | Real estate | 2021 |
| Shine Blue Construction Ltd | Construction | 2022 |
| Shine Care Services Ltd | Health & social care | 2015 |
| Shine Care Supported Living Services Limited | Administrative & support | 2023 |
| Shine House Cleaning Services Kent Ltd | Administrative & support | 2021 |
| Shiny Sky Window Cleaning Ltd | Administrative & support | 2025 |
| Ship Shape Engineering Ltd | Manufacturing | 2025 |
| Shire Retirement Housing Ltd | Construction | 2025 |
| Shiro Design Limited | Professional & scientific | 2021 |
| Shish Shack Ltd | Hospitality | 2018 |
| Shisha Delight Limited | Administrative & support | 2022 |
| Shivakshetram School of Dance Ltd | Education | 2023 |
| Shivam Gaura Ltd | Construction | 2025 |
| SHJ Business Limited | Real estate | 2021 |
| Shoker Investments Group Ltd | Real estate | 2024 |
| Shoket Yummy Delicacy Ltd | Hospitality | 2026 |
| Sholto Ltd | Professional & scientific | 2026 |
| Shona.H Limited | Health & social care | 2022 |
| Shooting Cars Ltd | Administrative & support | 2022 |
| Shop Strelley Ltd | Wholesale & retail | 2026 |
| Shopick Wheel Ltd | Wholesale & retail | 2018 |
| Shopie.Com Ltd | Real estate | 2024 |
| Shopply Ltd | Wholesale & retail | 2024 |
| Shotcrete Limited | Extraterritorial | 2001 |
| Shreeve Protection Services Ltd | Construction | 2004 |
| Shrimp Brand Beers Ltd | Manufacturing | 2023 |
| SHS Shoe Care Limited | Manufacturing | 2017 |
| SHY Auto Developments Ltd. | Wholesale & retail | 2002 |
| Sian Formwork (UK) Limited | Real estate | 2008 |
| Sian Formwork Limited | Construction | 2003 |
| Sian Group Holdings Limited | Financial services | 2018 |