| SDJ Group Ltd | Hospitality | 2024 |
| Sdukl Limited | Manufacturing | 2013 |
| Se-Sol Services Ltd | Information & communication | 2012 |
| Sea Kayak Devon Limited | Arts & recreation | 2013 |
| Sea Kayak Dorset Limited | Arts & recreation | 2022 |
| Seabright Developments Ltd | Construction | 2023 |
| Seabright Estates Ltd | Real estate | 2023 |
| Seabright Investments Ltd | Real estate | 2023 |
| Seagers Court Limited | Households | 2023 |
| Sealion Enterprises Limited | Hospitality | 2020 |
| Sean Lawless Carpentry Ltd | Construction | 2013 |
| Sean Prescott Nutrition and Fitness Ltd | Education | 2024 |
| Searchlight Media Limited | Administrative & support | 2013 |
| Searle Agricultural Services Limited | Agriculture & fishing | 2015 |
| Searle Construction (Glos) Ltd | Construction | 2009 |
| Seaside Directory Limited | Administrative & support | 2018 |
| Seaside Marketing Limited | Administrative & support | 2017 |
| Season One Communications Limited | Administrative & support | 2024 |
| Season to DA Bone Limited | Hospitality | 2023 |
| Seasonal Shipping Ltd | Wholesale & retail | 2025 |
| Seastrop Ltd | Manufacturing | 2018 |
| Seats Group Limited | Transport & logistics | 2022 |
| Seba IT Consulting Ltd | Information & communication | 2015 |
| Sebnico Transport Ltd | Transport & logistics | 2023 |
| Seca Care Limited | Health & social care | 2020 |
| Second Rock Limited | Professional & scientific | 2016 |
| Second Tree Limited | Financial services | 2025 |
| Secret Garden Nursery Limited | Education | 2012 |
| Secret Shakespeare Ltd | Arts & recreation | 2024 |
| Sector 6 Software Ltd | Information & communication | 2023 |
| Secure ARC Limited | Wholesale & retail | 2013 |
| Secure Hope Services Ltd | Administrative & support | 2017 |
| Secure Systems & Technologies Limited | Manufacturing | 2002 |
| Security & Solar Window Films Limited | Administrative & support | 2007 |
| Security 1 Holdings Limited | Financial services | 2023 |
| Security 1 Limited | Public administration | 2002 |
| Security Affairs Ltd | Information & communication | 2024 |
| Security Keys Limited | Wholesale & retail | 2017 |
| Sedum House Limited | Households | 1969 |
| SEE Dynamics Ltd | Information & communication | 2026 |
| Seib Insurance Brokers Limited | Financial services | 2007 |
| Self Reliance Energy Limited | Financial services | 2025 |
| Seller Nexus Limited | Wholesale & retail | 2026 |
| Sellevia Ltd | Wholesale & retail | 2026 |
| Sellick Property Developments Ltd | Construction | 2024 |
| Sennen Cove View Property Management Company Limited | Households | 2020 |
| Sensndt Ltd | Professional & scientific | 2023 |
| Sentinel Shield Protection Limited | Administrative & support | 2026 |
| Sentrain Ltd | Professional & scientific | 2013 |
| Sequaspire Ltd | Information & communication | 2024 |
| Sequels Healthcare Limited | Health & social care | 2022 |
| Serck Separation Technologies Limited | Manufacturing | 2012 |
| Serenity Pathways Ltd | Education | 2025 |
| Serial/Trash Ltd | Information & communication | 2009 |
| Serlo Enterprises Limited | Hospitality | 1994 |
| Serveaccom Ltd | Real estate | 2025 |
| Service Clean Ltd | Wholesale & retail | 2026 |
| Service Extrusion Consultants Ltd | Wholesale & retail | 2014 |
| Serviced Holiday Apartments Ltd | Real estate | 2019 |
| Serwecinska Properties Ltd | Real estate | 2024 |
| Sesamoid Healthcare Limited | Health & social care | 2002 |
| Sessvv Limited | Hospitality | 2025 |
| SET Operations Limited | Transport & logistics | 2018 |
| Seven Breath Pictures Ltd | Information & communication | 2018 |
| Seven Gates Property Limited | Financial services | 2022 |
| Seven Horizons Global Ltd | Wholesale & retail | 2026 |
| Seven Lions Media Limited | Information & communication | 2020 |
| Seven Springs Lifestyle Ltd | Real estate | 2026 |
| Sevenhomes Limited | Households | 1968 |
| Severn and WYE Lime Ltd | Manufacturing | 2023 |
| Severn Farm Limited | Financial services | 2018 |
| Severn Farm Secure Dog Field Limited | Arts & recreation | 2020 |
| Severn Football Academy Limited | Education | 2018 |
| Severn Glocon (Aberdeen) Ltd | Wholesale & retail | 2010 |
| Severn Glocon Limited | Manufacturing | 1961 |
| Severn Glocon UK Valves Limited | Manufacturing | 2019 |
| Severn Management Services (Gloucester) Limited | Information & communication | 1989 |
| Severn Restoration Services Ltd | Administrative & support | 2024 |
| Severn Screeding Services Limited | Construction | 2006 |
| Severn Signs Limited | Manufacturing | 2001 |
| Severn Softeners Ltd | Water & waste | 2019 |
| Severn Sparks Ltd | Construction | 2020 |
| Severn Sunrise Homecare Limited | Health & social care | 2016 |
| Severn Training Group Ltd | Education | 2022 |
| Severn Unival Limited | Manufacturing | 1981 |
| Severn Vale Bathrooms Ltd | Wholesale & retail | 2006 |
| Severn Vale School | Education | 2011 |
| Severn Valley Academy Ltd | Arts & recreation | 2018 |
| Severn Valley Car Company Ltd | Real estate | 2009 |
| Severn WYE Biochar Limited | Professional & scientific | 2023 |
| Severn WYE Energy Agency Ltd. | Administrative & support | 1999 |
| Severnside Engineering Limited | Professional & scientific | 2015 |
| Severnside Epney Limited | Professional & scientific | 2010 |
| Severnside Heating & Plumbing Limited | Construction | 2019 |
| Severnside K9 Ltd | Other services | 2024 |
| Severnside Property Limited | Construction | 2019 |
| Severnside Refinishing Limited | Wholesale & retail | 2011 |
| Severnside Scaffolding Limited | Construction | 1973 |
| Severnsidemorley Limited | Financial services | 1988 |
| Severnview Home Improvements Ltd | Construction | 2022 |