| Safran Landing Systems Pension Trustees Limited | Financial services | 1998 |
| Safran Landing Systems Services UK Ltd | Manufacturing | 1998 |
| Safran UK Limited | Professional & scientific | 1987 |
| Sage Turner Ltd | Construction | 2008 |
| SAH Insulation Limited | Construction | 2020 |
| Sahara Kitchen Ltd | Hospitality | 2024 |
| Sahartech Printing Corporation Ltd. | Manufacturing | 2016 |
| Sahiti Homes Ltd | Real estate | 2023 |
| Sahyadri Global Ltd | Wholesale & retail | 2025 |
| SAI Dham Limited | Real estate | 2019 |
| Saikaruppar Sabari Limited | Information & communication | 2024 |
| Sail-Freight Limited | Transport & logistics | 2016 |
| Sailor Studio Ltd | Professional & scientific | 2022 |
| Saint Christopher Clothing Limited | Wholesale & retail | 2024 |
| Saints Builders Merchants Limited | Wholesale & retail | 2007 |
| Saion Volt Ltd | Professional & scientific | 2026 |
| Saitmg Realty Limited | Real estate | 2023 |
| Saivar Solutions Ltd | Information & communication | 2026 |
| SAL Spedition Ltd | Transport & logistics | 2018 |
| Sales Solutions Group Limited | Professional & scientific | 2019 |
| Salle 10 Ltd | Education | 2026 |
| Saltwater Investments Limited | Real estate | 2021 |
| Sam's Deli Ltd | Hospitality | 2024 |
| SAMANTA210 Limited | Wholesale & retail | 2025 |
| Sami & Shalu Investments Limited | Real estate | 2021 |
| Sami Properties PVT Ltd | Real estate | 2022 |
| Samjay Equipment Ltd | Administrative & support | 2023 |
| Samjay Property Ltd | Real estate | 2025 |
| Sams PAN Pizzas Ltd | Hospitality | 2026 |
| Samson Lifting (UK) Ltd | Manufacturing | 2010 |
| SAN Jaume Property Ltd | Administrative & support | 2010 |
| Sana & Omer Barber Ltd | Other services | 2025 |
| Sanctum Holdings Limited | Financial services | 2020 |
| Sanctus Group Holdings Limited | Real estate | 2016 |
| Sanctus Limited | Water & waste | 2003 |
| Sanctus Training Limited | Education | 2010 |
| Sand Academies Trust | Education | 2019 |
| Sanderson Anaesthesia Limited | Health & social care | 2019 |
| Sandgrouse Limited | Wholesale & retail | 2021 |
| Sandra DEE Limited | Wholesale & retail | 2001 |
| Sandy Patch Properties Ltd | Real estate | 2024 |
| Sandywell Park Limited | Households | 1996 |
| Sang Energy Consulting Limited | Professional & scientific | 2012 |
| Santaka Actionis Ltd | Information & communication | 2016 |
| Santiago Investments Ltd | Real estate | 2023 |
| SAP Property Project Ltd | Real estate | 2018 |
| Saqib Trading Ltd | Wholesale & retail | 2025 |
| Sara Doyle Ltd | Information & communication | 2014 |
| Sara Grill Restaurant Limited | Hospitality | 2026 |
| Sarah Kelly Consultancy Limited | Professional & scientific | 2025 |
| Sarah Wyer Limited | Health & social care | 2012 |
| Sarakan Limited | Manufacturing | 1971 |
| Sargeant & Sargeant Hospitality Limited | Hospitality | 2018 |
| Saron Hospitality Ltd | Hospitality | 2018 |
| Saru-Systems Limited | Extraterritorial | 2008 |
| SAS Solutions Southwest Ltd | Construction | 2024 |
| Satirical Plays Ltd | Arts & recreation | 2025 |
| Satoripaint Limited | Information & communication | 2022 |
| Satsuma Ltd | Professional & scientific | 2021 |
| Savages MC Limited | Administrative & support | 2024 |
| Savannah Connect UK Ltd | Professional & scientific | 2025 |
| Savannah Miller Limited | Professional & scientific | 2014 |
| Saver Wholesale Limited | Wholesale & retail | 2025 |
| Saving Swaps Ltd | Wholesale & retail | 2023 |
| Saxon Commercial Developments Ltd | Construction | 2025 |
| Saxon Corp Ltd | Wholesale & retail | 2024 |
| Saxon Gate (Leonard Stanley) Management Company Limited | Households | 2017 |
| Saxon Property Holdings Ltd | Real estate | 2016 |
| Saxon Property Trading Limited | Real estate | 2022 |
| SBG Developments Ltd | Real estate | 2023 |
| Scaffold Properties Limited | Real estate | 2024 |
| Scarcity Supply Ltd | Wholesale & retail | 2026 |
| SCB Training Services Limited | Administrative & support | 2013 |
| Sceemo Limited | Manufacturing | 2016 |
| Scented Saviours Ltd | Other services | 2025 |
| Sceptre Industries UK Limited | Wholesale & retail | 2024 |
| SCH Group Limited | Professional & scientific | 2019 |
| Scholarly & Academic Services Limited | Administrative & support | 2015 |
| School Lane Estates Limited | Households | 1974 |
| Schoolpro Curriculum Limited | Education | 2025 |
| Schoolpro TLC Limited | Education | 2016 |
| Scilly Holiday Cottages Limited | Hospitality | 2017 |
| Scilly Self-Catering Ltd. | Hospitality | 2010 |
| Scion Group Limited | Professional & scientific | 2000 |
| Scion Property Services Limited | Extraterritorial | 1933 |
| Scion Technical Services Limited | Professional & scientific | 1998 |
| SCO Transport Limited | Transport & logistics | 2016 |
| Scoopistry Ltd | Wholesale & retail | 2025 |
| Scope Building & Landscaping Limited | Construction | 2019 |
| Scorchio Heating Limited | Construction | 2015 |
| Scorer Building Limited | Construction | 2004 |
| Scott Harris Consultancy Ltd | Administrative & support | 2019 |
| Screenjet Limited | Information & communication | 1999 |
| Scribble Press Limited | Information & communication | 1997 |
| Scsi Holdings Limited | Administrative & support | 1998 |
| Scuffs Away (Gloucester) Ltd | Wholesale & retail | 2022 |
| Scutum Virtutis Ltd | Information & communication | 2025 |
| SD Consultancy (Cotswolds) Ltd | Professional & scientific | 2024 |
| SDG Agri Ltd | Agriculture & fishing | 2024 |
| SDG Groundwork Solutions Ltd | Construction | 2014 |