| Severnway Homes SW Ltd | Real estate | 2024 |
| Sevinc Mobile Barber Ltd | Other services | 2017 |
| Sevtek Engineering Services Limited | Manufacturing | 2002 |
| Seymour Baps Ltd | Real estate | 2022 |
| Seymour Spice Ltd | Hospitality | 2024 |
| Seysa Limited | Hospitality | 2019 |
| SF ANP Limited | Health & social care | 2016 |
| SF Lettings Ltd | Real estate | 2018 |
| SF Loos Limited | Other services | 2021 |
| SF Security Ltd | Administrative & support | 2026 |
| Sflec Limited | Education | 2010 |
| SG Art Supplies Ltd | Education | 2025 |
| SG Driveways Limited | Administrative & support | 2025 |
| SG Electrical Contracting Limited | Construction | 2023 |
| SG Midco Limited | Financial services | 2019 |
| SGW Trading Ltd | Education | 2025 |
| SH Brunel Limited | Hospitality | 2019 |
| SH Granary Limited | Hospitality | 2023 |
| SH1 Limited | Hospitality | 2020 |
| SH3 Limited | Hospitality | 2020 |
| SH4 Limited | Hospitality | 2020 |
| SH5 Limited | Hospitality | 2020 |
| SH6 Limited | Hospitality | 2020 |
| Shaddl Corporate Ltd | Transport & logistics | 2018 |
| Shadson Ltd | Wholesale & retail | 2024 |
| Shah Accountants Ltd | Professional & scientific | 2023 |
| Shah's Store Ltd | Wholesale & retail | 2025 |
| Shaho Property Ltd | Real estate | 2025 |
| Shair Services Limited | Professional & scientific | 2025 |
| Shakera Catering Ltd | Manufacturing | 2023 |
| Shakespeare Davenport Limited | Administrative & support | 2011 |
| Shan Property Ltd | Real estate | 2020 |
| Shan Retailing Ltd | Wholesale & retail | 2021 |
| Shandy Shack Ltd | Manufacturing | 2018 |
| Shape 360 Limited | Hospitality | 2024 |
| SHAPE360-COMMUNITY CIC | Hospitality | 2025 |
| Shaqz Limited | Wholesale & retail | 2025 |
| Shared Churches (Gloucester) Limited | Construction | 1993 |
| Shark Squad Ltd | Education | 2023 |
| Sharma Prasaba Ltd | Health & social care | 2025 |
| Sharon Langford Ltd | Transport & logistics | 2014 |
| Sharp Life & Learning Skills CIC | Education | 2014 |
| Sharper Detailing Ltd | Administrative & support | 2025 |
| Shaun Hawkins Groundworks Ltd | Construction | 2014 |
| Shawbrook Solutions Limited | Information & communication | 2019 |
| Shawtap Limited | Households | 1986 |
| Shayle Enterprise Ltd | Agriculture & fishing | 2017 |
| Shayle Farm and Wood Ltd | Agriculture & fishing | 2015 |
| SHB Transport Limited | Administrative & support | 2024 |
| SHE Golden Eagle Limited | Extraterritorial | 2020 |
| Sheamol ALI Holdings Ltd | Wholesale & retail | 2026 |
| Sheeba Retail Services Ltd | Wholesale & retail | 2026 |
| Sheikh Enterprise Ltd | Wholesale & retail | 2025 |
| Shelby LEA Coffee Ltd | Hospitality | 2025 |
| Shelby LEA Limited | Real estate | 2023 |
| Shelby LEA Representatives Ltd | Extraterritorial | 2023 |
| Shelby Services Ltd | Transport & logistics | 2019 |
| Shellam Joinery Ltd | Construction | 2007 |
| Shelltta Ltd | Health & social care | 2021 |
| Shell’S Sparkle & Shine Ltd | Households | 2023 |
| Shelving and Partitioning Systems Limited | Construction | 1997 |
| Sheneel Investments Private Limited | Financial services | 2020 |
| Shepherd's Transport Ltd | Transport & logistics | 2026 |
| Sher and Sons Enterprises Ltd | Wholesale & retail | 2026 |
| Shera Holdings Limited | Real estate | 2024 |
| Sherchan & Daughters Ltd | Hospitality | 2018 |
| Sherlock Homes Properties Ltd | Real estate | 2023 |
| Shev Building Ltd | Construction | 2025 |
| Shftyscents Ltd | Wholesale & retail | 2024 |
| Shifahoneyuk Ltd | Wholesale & retail | 2025 |
| Shikido Ltd | Other services | 2025 |
| Shimla Gloucester Ltd | Hospitality | 2019 |
| Shimla Spice Gloucester Ltd | Hospitality | 2023 |
| Shipping Management Services Limited | Manufacturing | 1988 |
| Shipping Services Direct Ltd | Transport & logistics | 2026 |
| Shipston Community Care Limited | Health & social care | 2025 |
| Shipton Oliffe Management Limited | Professional & scientific | 1996 |
| Shire Cafe Ltd | Hospitality | 2025 |
| Shire Energy Ltd | Construction | 2024 |
| Shire Hot Tubs Ltd | Wholesale & retail | 2024 |
| Shire Oak International Limited | Construction | 2018 |
| Shire Oak Quarries Limited | Mining & quarrying | 2014 |
| Shire Property and Leisure Ltd | Construction | 2024 |
| Shiretech Solutions Limited | Information & communication | 2019 |
| SHJ Consultancy Ltd | Professional & scientific | 2017 |
| Shoetrendz Limited | Wholesale & retail | 2022 |
| Sholdams Ltd | Real estate | 2023 |
| Shoot Gear Ltd | Wholesale & retail | 2016 |
| Shop of Kebab Ltd | Hospitality | 2026 |
| Shoplix Ltd | Wholesale & retail | 2025 |
| Shopvella Traders Ltd | Wholesale & retail | 2026 |
| Shore & Country Settings Ltd | Real estate | 2022 |
| Short Stays Management Ltd | Real estate | 2024 |
| Shot by Kieran Ltd | Information & communication | 2021 |
| Shoulders of Giants Limited | Professional & scientific | 2015 |
| Showdown Elite Events Ltd | Arts & recreation | 2024 |
| Shox OFF Limited | Wholesale & retail | 2023 |
| Shredbox Gym Ltd | Arts & recreation | 2025 |
| Shropshire Dental Holdings Limited | Financial services | 2022 |
| Shropshire Dental Limited | Professional & scientific | 2015 |