| Sadler Geotechnics Ltd | Construction | 2019 |
| Sadste Holdings Ltd | Professional & scientific | 2014 |
| Safebox Storage Limited | Transport & logistics | 2024 |
| Safeguard Financial Services Limited | Financial services | 2006 |
| Safeguard Property Limited | Financial services | 2014 |
| Safer at Work Ltd | Wholesale & retail | 2017 |
| Safety 1ST GAS and Electric Limited | Professional & scientific | 2020 |
| Safinah Limited | Professional & scientific | 1998 |
| Sahara TAN Limited | Other services | 2023 |
| Saint Cuthbert Homes Limited | Extraterritorial | 2021 |
| Sajids Cuisine Ltd | Hospitality | 2019 |
| Sajis Street Food Ltd | Hospitality | 2026 |
| Salams Kitchen Ltd | Hospitality | 2025 |
| Salbrook Vance Limited | Professional & scientific | 2014 |
| Salecycle Limited | Information & communication | 2010 |
| Saleems Desserts Limited | Hospitality | 2016 |
| Saleems Property Developments Ltd | Real estate | 2018 |
| Salem's Access Services Ltd | Construction | 2024 |
| Salim Health Ltd | Health & social care | 2019 |
| Salon Spaces Ltd | Other services | 2022 |
| SALON712 Ltd | Other services | 2022 |
| Saltburn House Limited | Real estate | 2015 |
| Saltwell Chip Stop Ltd | Hospitality | 2025 |
| Saltwell Chippy Ltd | Hospitality | 2015 |
| Saltwell Estates Ltd | Real estate | 2024 |
| Saltwell Memorials Ltd | Manufacturing | 2025 |
| Saltwell Newsagents Ltd | Wholesale & retail | 2024 |
| Saltwell Park Developments Ltd | Construction | 2012 |
| Sam's Empire Ltd | Construction | 2024 |
| Samajayn Limited | Health & social care | 2022 |
| Samam Holdings Ltd | Financial services | 2021 |
| Sambuca Trinity Square Ltd | Hospitality | 2019 |
| Samco Lettings Limited | Real estate | 2015 |
| Sameach | Other services | 2002 |
| Sameach Bayis Investments Limited | Real estate | 2025 |
| Sameach Bayis Limited | Real estate | 2023 |
| Sameach Investments Ltd | Real estate | 2022 |
| Sami Askari Limited | Transport & logistics | 2025 |
| Samira Essence Ltd | Wholesale & retail | 2026 |
| Samprop Limited | Real estate | 2018 |
| Samsstyle Limited | Information & communication | 2023 |
| Sanctuary Aesthetica Ltd | Wholesale & retail | 2022 |
| Sandancer Holdings Limited | Manufacturing | 2021 |
| Sandco 1038 Limited | Professional & scientific | 2007 |
| Sandco 1053 Limited | Real estate | 2007 |
| Sanderson and Ennis Ltd | Real estate | 2022 |
| Sanderson Smith Ltd | Other services | 2026 |
| Sandgate 21 Limited | Extraterritorial | 2019 |
| Sandhu Fish Bar NE Ltd | Hospitality | 2017 |
| Sangi Techo Solutions Limited | Information & communication | 2022 |
| Sanjay Shipping Corporation Limited | Administrative & support | 2021 |
| Sans Inc. Ltd | Wholesale & retail | 2020 |
| Santos Properties Ltd | Other services | 2018 |
| Santus Circus Equipment Limited | Administrative & support | 2007 |
| Sapori Gateshead Ltd | Hospitality | 2024 |
| Sara Jobling Consultancy Limited | Education | 2011 |
| Sarah Dela Torre Ltd | Health & social care | 2017 |
| Sarbo Health Limited | Health & social care | 2022 |
| Sardun Ltd | Real estate | 2020 |
| Sarkless Training Ltd | Education | 2025 |
| Sarloe Limited | Real estate | 2017 |
| SAS Proactive Ltd | Administrative & support | 2019 |
| Saskia Fitness Limited | Arts & recreation | 2025 |
| Sauk Medicals Ltd | Health & social care | 2023 |
| Saunders House Farm Ltd | Agriculture & fishing | 2023 |
| Saviours Pharma Consultancy Limited | Health & social care | 2016 |
| Savour Bakery Cafe & Patisserie Ltd | Wholesale & retail | 2024 |
| Savoy Beds and Furniture Ltd | Construction | 2020 |
| Saw.Hy Ltd | Wholesale & retail | 2019 |
| SAWASDEE1166 Limited | Public administration | 2020 |
| Saxon Event Crew Limited | Extraterritorial | 2024 |
| SAY Travel Management Ltd | Transport & logistics | 2025 |
| Sayyaar Technologies Ltd | Transport & logistics | 2025 |
| SB (North Shields) Limited | Professional & scientific | 2010 |
| SB Vafa Logistics Ltd | Transport & logistics | 2025 |
| Sbands Limited | Hospitality | 2019 |
| SBH Residential Limited | Real estate | 2025 |
| SC Aero Limited | Professional & scientific | 2013 |
| Scad Ltd | Education | 2007 |
| Scaffold North Limited | Construction | 2011 |
| Scantime Automation Ltd | Information & communication | 2024 |
| Scantime Group Limited | Financial services | 2023 |
| Scantime Training Limited | Information & communication | 2004 |
| Scarlet Ocean Ltd | Wholesale & retail | 2019 |
| Scentfulhub Limited | Administrative & support | 2022 |
| Schleider's Suites Ltd | Hospitality | 2022 |
| Scholars Nest Ltd | Real estate | 2024 |
| Scholle IPN UK Ltd. | Manufacturing | 1997 |
| Scintilla Fitness Limited | Arts & recreation | 2025 |
| Scire Group Limited | Health & social care | 2023 |
| Scope Energy Solutions Ltd | Energy | 2015 |
| Scope Green Solutions Ltd | Construction | 2023 |
| Scope Utility Solutions Ltd | Construction | 2019 |
| Scopeagreed Limited | Information & communication | 2026 |
| Score Marketing Ltd | Wholesale & retail | 2019 |
| Scotpack Ltd | Manufacturing | 2018 |
| Scott Accountancy Services (North East) Ltd | Professional & scientific | 2014 |
| Scott Fencing Limited | Construction | 2004 |
| Scott Wilson Services Limited | Construction | 2019 |
| Scredington Choice Ltd | Transport & logistics | 2014 |