| Screen Services (NE) Limited | Manufacturing | 1999 |
| Script Supply Ltd | Wholesale & retail | 2026 |
| SD Electrical Supervision Solutions Limited | Construction | 2025 |
| SD Industries Limited | Manufacturing | 2018 |
| SD Legal Recruitment Ltd | Administrative & support | 2025 |
| SD Night Care Ltd | Health & social care | 2016 |
| SD Prestige Entertainment Limited | Arts & recreation | 2018 |
| SDB Engineering Services Ltd | Construction | 2015 |
| Sea Engineer Limited | Construction | 2016 |
| Seadall Limited | Administrative & support | 2018 |
| Seal NE Ltd | Professional & scientific | 2025 |
| Seal Partnership Limited | Real estate | 2013 |
| Seal Properties (North West) Limited | Real estate | 2026 |
| Seal Properties Holdings Limited | Real estate | 2022 |
| Sealco Cosmetics Ltd | Wholesale & retail | 2016 |
| Seansey Limited | Real estate | 2017 |
| Searchrise Limited | Professional & scientific | 2015 |
| Seascape Surveillance Ltd | Professional & scientific | 2023 |
| Seasons (North East) Limited | Hospitality | 2009 |
| Seaton Car Sales Limited | Wholesale & retail | 2024 |
| Seaton Carew Properties Limited | Real estate | 2024 |
| Secure Coast Technologies Ltd | Information & communication | 2015 |
| Secure Property International Ltd | Real estate | 2011 |
| Security Professionals Support Co-Operative C.I.C. | Administrative & support | 2017 |
| Seech Global Ltd | Construction | 2025 |
| Segero Consultants Limited | Information & communication | 2015 |
| Sele Coffee Ltd | Hospitality | 2023 |
| Select Control Systems Limited | Manufacturing | 1998 |
| Select Windows and Glass Ltd | Manufacturing | 2016 |
| Self Assessment Processing Company Limited | Professional & scientific | 2005 |
| Selikta Innovative Solutions Limited | Information & communication | 2025 |
| Sellar & Stone Limited | Wholesale & retail | 2026 |
| Sempiternal Partnership Limited | Real estate | 2021 |
| Sense Ability Matters Ltd. | Health & social care | 2004 |
| Sentinel Surveyors Ltd | Professional & scientific | 2018 |
| SEO Tweaks Ltd | Information & communication | 2019 |
| Separate Reality Limited | Information & communication | 2002 |
| Sequestor Carbon Capture Ltd | Construction | 2025 |
| Sequestor Energy Limited | Construction | 2025 |
| Sequestor Holdings Limited | Construction | 2025 |
| Sera Retail Ltd | Wholesale & retail | 2023 |
| Serd Clothing Limited | Wholesale & retail | 2025 |
| Serendipiti Limited | Real estate | 2018 |
| Serenity Planet Limited | Construction | 2020 |
| Service 2000 GAS Service and Maintenance Limited | Manufacturing | 2011 |
| SET Cleaning & Maintenance Ltd | Administrative & support | 2025 |
| Seta Property Services Limited | Real estate | 2018 |
| Setay Management Limited | Professional & scientific | 2011 |
| Seven Keys Ltd | Real estate | 2018 |
| Seven Sources Limited | Real estate | 2015 |
| Seven Stones Counselling Ltd | Education | 2026 |
| Seventyfour Ninetythree Creatives Ltd | Other services | 2022 |
| SF Analytical Services Ltd | Other services | 2020 |
| SF Electrical Installations Limited | Construction | 2024 |
| SF Surgical Ltd | Health & social care | 2019 |
| SFM Solutions Limited | Manufacturing | 2025 |
| SG Cars Motor Group Ltd | Wholesale & retail | 2025 |
| SGL Fabrications Ltd | Manufacturing | 2011 |
| SGR Private Ltd | Health & social care | 2022 |
| Shabris Ltd | Real estate | 2021 |
| Shabs Solutions Ltd | Wholesale & retail | 2019 |
| Shackmor Ltd | Real estate | 2021 |
| Shada Fades Ltd | Other services | 2024 |
| Shadbolt Consulting Limited | Professional & scientific | 2013 |
| Shaftesbury Care Limited | Professional & scientific | 1996 |
| Shaftesbury Society (the) | Education | 1893 |
| Shaheer PVT Limited | Transport & logistics | 2025 |
| Shajeelahaleema Ltd | Health & social care | 2023 |
| Shake & Cake Ltd | Wholesale & retail | 2019 |
| Shameem Bensham Ltd | Hospitality | 2022 |
| Shandwick Properties Limited | Real estate | 2008 |
| Shansha Takeaway Limited | Hospitality | 2024 |
| Shape UP Health Club Limited | Arts & recreation | 2025 |
| Sharan Limited | Real estate | 2025 |
| Sharp Media Group Limited | Information & communication | 2018 |
| Shaun Harland Access Ltd | Construction | 2026 |
| Shaun Richmond Rigging and Lifting Ltd | Construction | 2025 |
| Shavit Investment Ltd | Real estate | 2020 |
| Shawlands Construction (NE) Limited | Construction | 2019 |
| Sheby Consultants Ltd | Administrative & support | 2026 |
| Sheep and Clay Studios Limited | Information & communication | 2025 |
| Shefa Properties Ltd | Real estate | 2009 |
| Shell Hand Car Wash Ltd | Administrative & support | 2021 |
| Shell Management Ltd | Real estate | 2022 |
| Shell One Car Wash Ltd | Administrative & support | 2025 |
| Shelley Watts 2 Limited | Hospitality | 2021 |
| Shenoys and Sons Properties Ltd | Real estate | 2020 |
| Sheraton Estates Ltd | Real estate | 2016 |
| Sherburn Way Ltd | Financial services | 2025 |
| Sherif Medical Services Limited | Health & social care | 2011 |
| SHG Holdings Limited | Extraterritorial | 2007 |
| Shield TX (UK) Limited | Health & social care | 2008 |
| Shields Florists Ltd | Wholesale & retail | 2018 |
| Shift Driving School Ltd | Education | 2023 |
| Shiputz Ltd | Administrative & support | 2022 |
| Shlee Limited | Health & social care | 2019 |
| Shomer Ltd | Households | 2022 |
| Shoot Your Mouth OFF CIC | Arts & recreation | 2006 |
| Shooting Stars Basketball (North East) Limited | Arts & recreation | 2024 |
| Shopping Swift UK Ltd | Wholesale & retail | 2023 |