| DJT Engineering & Management Solutions Ltd | Professional & scientific | 2025 |
| DK Consultancy NE Limited | Professional & scientific | 2026 |
| DKD (NE) Limited | Manufacturing | 2021 |
| DL Glazing Ltd | Construction | 2024 |
| DL85 Ltd | Administrative & support | 2021 |
| Dlat Hill Limited | Administrative & support | 2003 |
| Dlguk Ltd | Information & communication | 2022 |
| DLH Property Solutions Ltd | Real estate | 2015 |
| DLP (NE) Ltd | Professional & scientific | 2012 |
| DM Electrical (NE) Ltd | Construction | 2023 |
| DM Property Repairs Ltd | Construction | 2013 |
| DMB Fixing Services Limited | Construction | 2018 |
| DMC (North Tyneside) Ltd | Professional & scientific | 2023 |
| DMC Accounting Services Limited | Professional & scientific | 2020 |
| Dmcf Consultancy Ltd | Professional & scientific | 2025 |
| Dmcnorth Limited | Professional & scientific | 2019 |
| DMG Electrical Services Ltd | Construction | 2009 |
| DMH Project Services Ltd | Professional & scientific | 2023 |
| DMH Property Partners Ltd | Real estate | 2025 |
| DMJ Surveying Limited | Professional & scientific | 2011 |
| DML Projects (NE) Ltd | Professional & scientific | 2025 |
| DMO Electrical Ltd | Construction | 2023 |
| DMR Holdings NE Ltd | Real estate | 2024 |
| DMV (JJ) Limited | Financial services | 2023 |
| DNA Flooring Ltd | Wholesale & retail | 2020 |
| DNA Motor Group Ltd | Wholesale & retail | 2021 |
| DNA Motor Group NE Ltd | Wholesale & retail | 2025 |
| Dnkeo Printing Ltd | Manufacturing | 2026 |
| Dobies (Carlisle) Limited | Extraterritorial | 1998 |
| Dobson Structures Ltd | Professional & scientific | 2022 |
| Docbee Limited | Health & social care | 2018 |
| Doctor MEO Limited | Information & communication | 2023 |
| Doctor O'Donovan - Medical Education Limited | Education | 2022 |
| Doggie Daycare and Boarding Service Ltd | Other services | 2026 |
| DOH Construction Limited | Construction | 2005 |
| DOM Nicholson Access Ltd | Manufacturing | 2018 |
| Domion Holdings Ltd | Construction | 2025 |
| Dommy’S Executive Valeting Services Ltd | Administrative & support | 2022 |
| DON Lambert Caravan Haulage Limited | Transport & logistics | 2002 |
| Donaghey and Sons Design Consultants Ltd | Professional & scientific | 2023 |
| Donald Gilberts Limited | Hospitality | 2017 |
| Donkin Propco Ltd | Real estate | 2018 |
| Donnelly Roofing Ltd | Construction | 2024 |
| Dotline Records Ltd | Information & communication | 2026 |
| Double Barrel Developments Ltd | Real estate | 2025 |
| Double Chief Limited | Health & social care | 2024 |
| Downcast Studios Limited | Information & communication | 2011 |
| DP Conveyancing & Property Law Limited | Professional & scientific | 2018 |
| DP Heating & GAS Ltd | Construction | 2022 |
| DP Supplies Ltd | Wholesale & retail | 2020 |
| Dp-Hvp Ltd | Construction | 2015 |
| DR Amin Ahmed Ltd | Health & social care | 2026 |
| DR Hot TUB Ltd | Manufacturing | 2019 |
| DR Julia Parker Coaching & Training Limited | Education | 2025 |
| DR Leam Ltd | Hospitality | 2025 |
| DR Potey Limited | Health & social care | 2016 |
| DR505 Limited | Professional & scientific | 2002 |
| Dragon Motorbikes Limited | Wholesale & retail | 2022 |
| Dragonmount (2016) Limited | Real estate | 2016 |
| Drainline NE Ltd | Water & waste | 2021 |
| Drakulic Solutions Ltd | Professional & scientific | 2023 |
| Drawingsmadesimple Ltd | Professional & scientific | 2023 |
| Dream Cuisine Foods Ltd | Hospitality | 2025 |
| Dream Salon Newcastle Ltd | Other services | 2021 |
| Dreamlaboratory Ltd | Manufacturing | 2010 |
| Dreamworks Bedrooms & Kitchens NE Ltd | Other services | 2025 |
| Drei Productions Limited | Arts & recreation | 2021 |
| Drew Dalton Consulting Limited | Professional & scientific | 2024 |
| Drew's Group Ltd | Financial services | 2024 |
| DREW83 (NE) Limited | Administrative & support | 2025 |
| Drew’S Roofing Ltd | Construction | 2025 |
| Drfout Consulting Ltd | Information & communication | 2023 |
| Drgkumar Ltd | Health & social care | 2021 |
| Dript Ltd | Hospitality | 2025 |
| DRIVE2RECRUIT Limited | Administrative & support | 2010 |
| Drives and Patios NE Limited | Construction | 2021 |
| Drone Industries Limited | Professional & scientific | 2014 |
| Drongate Ltd | Real estate | 2021 |
| Drsufk Ltd | Education | 2024 |
| DRT Consulting Ltd | Professional & scientific | 2011 |
| DRT Logistics Ltd | Transport & logistics | 2026 |
| Drury Financial Services Limited | Financial services | 2012 |
| DRW Project Consultancy Limited | Professional & scientific | 2016 |
| Dryden Management Services Limited | Professional & scientific | 2019 |
| DRZ Electrical Limited | Construction | 2019 |
| DS Dairies Ltd | Wholesale & retail | 2019 |
| DS Electrical Services (NE) Limited | Construction | 2022 |
| DS Electrical Solutions NE Ltd | Construction | 2025 |
| DS Investments (North East) Limited | Administrative & support | 2013 |
| DSB Property Group Ltd | Real estate | 2026 |
| DSC Holiday Lettings Limited | Hospitality | 1996 |
| DSH Investments NE Ltd | Real estate | 2023 |
| DTJ Drywall Systems Limited | Construction | 2019 |
| DTP CNC Services Ltd | Professional & scientific | 2017 |
| DTS Consult Ltd | Professional & scientific | 2023 |
| DTW Holdings & Investments Ltd | Financial services | 2026 |
| DUA Assets Ltd | Real estate | 2025 |
| Dubsmore Holdings Limited | Financial services | 2025 |
| Duckroo Ltd | Information & communication | 2021 |
| Duffys Motors Ltd | Wholesale & retail | 2017 |