| Duggal Investments Ltd | Real estate | 2025 |
| Dunbul Construction Ltd | Construction | 2019 |
| Dunmos Ltd | Real estate | 2011 |
| Dunntech (NE) Limited | Construction | 2018 |
| Dunston Activity Centre | Public administration | 2016 |
| Dunston Appliance Centre Ltd | Wholesale & retail | 2002 |
| Dunston Chippy (North East) Ltd | Hospitality | 2025 |
| Dunston Chippy Ltd | Hospitality | 2018 |
| Dunston Deli Ltd | Hospitality | 2022 |
| Dunston Family Church | Other services | 2016 |
| Dunston Hand Car Wash Ltd | Other services | 2017 |
| Dunston Heritage and Craft Centre Community Interest Company | Hospitality | 2024 |
| Dunston Kurdish Barber Ltd | Other services | 2021 |
| Dunston Road Motor Company Ltd | Wholesale & retail | 2019 |
| Dunston Roadside Services UK Ltd | Wholesale & retail | 2024 |
| Dunston Service Station Limited | Wholesale & retail | 1992 |
| Dunston UTS (FC) Limited | Arts & recreation | 2022 |
| Durham Cooling Ltd | Extraterritorial | 2025 |
| Durham County Rugby Football Union Limited | Arts & recreation | 2017 |
| DUS NE Limited | Manufacturing | 2021 |
| DVB Power Ltd | Professional & scientific | 2022 |
| DVN Inspection Ltd | Administrative & support | 2008 |
| Dyari Properties Ltd | Real estate | 2025 |
| Dybm Ltd | Real estate | 2017 |
| Dyce Limited | Real estate | 2002 |
| Dynamic Surface Repair Ltd | Manufacturing | 2020 |
| Dynamiq Luxury Homes Limited | Real estate | 2025 |
| Dynamix Extreme C.I.C. | Transport & logistics | 2007 |
| Dyslexia North East | Education | 2008 |
| DYW Design Ltd | Professional & scientific | 2023 |
| E & F Investments Ltd | Administrative & support | 2020 |
| E & F Property Ltd | Real estate | 2020 |
| E & R Property Services Ltd | Real estate | 2026 |
| E Bush Property Holdings Limited | Real estate | 2024 |
| E Caraman Ltd | Health & social care | 2015 |
| E Idris Ltd | Health & social care | 2025 |
| E Lewis Plumbing and Heating Limited | Construction | 2018 |
| E&B Geulah Ltd | Real estate | 2019 |
| E&H Investments Limited | Real estate | 2016 |
| E&I Quality Control Services Ltd | Professional & scientific | 2020 |
| E&S Vellore Limited | Health & social care | 2025 |
| E.M.H Estates Ltd | Real estate | 2014 |
| E.Storey & Sons Limited | Wholesale & retail | 1963 |
| E14MSOLUTIONS Limited | Administrative & support | 2019 |
| E2E Homecare Ltd | Health & social care | 2019 |
| EA Services (Gateshead) Ltd | Hospitality | 2021 |
| Eagle Dreams Ltd | Real estate | 2017 |
| Eagle's Cuts Limited | Other services | 2024 |
| EAR Oasis Ltd | Health & social care | 2026 |
| Earlsway and Temperence Holdings Limited | Real estate | 2020 |
| Earnshaw Estates Ltd | Real estate | 2016 |
| Easiaccess Limited | Extraterritorial | 2010 |
| Easibathe Limited | Construction | 1999 |
| Easiglaze Ltd | Construction | 2018 |
| East Coast Creations Ltd | Construction | 2020 |
| East Holton Charity | Health & social care | 1992 |
| East Lothian Estates Ltd | Real estate | 2015 |
| Easter Circus Limited | Arts & recreation | 2023 |
| Eastern Promise Ltd | Hospitality | 2015 |
| Eastgate Homes LLP | | 2006 |
| Easy Card Services Ltd | Financial services | 2019 |
| Easycertain Limited | Professional & scientific | 2025 |
| Easyprescribe Limited | Health & social care | 2025 |
| EBI Hair Limited | Wholesale & retail | 2026 |
| Eclipse Wholesale Group Ltd | Information & communication | 2001 |
| Ecms Case Management Services Limited | Health & social care | 2025 |
| Ecms Education Services Limited | Education | 2025 |
| Ecms Training Ltd | Education | 2024 |
| Eco Aggregates North East Ltd | Construction | 2024 |
| Eco Alliance Limited | Extraterritorial | 2020 |
| Eco Bird Food Ltd | Wholesale & retail | 2023 |
| Eco Door Systems Ltd | Manufacturing | 2024 |
| Eco Leaf Brokerage Services Ltd | Water & waste | 2019 |
| Eco Logic Corporate Limited | Energy | 2025 |
| Eco Logic Holdings Limited | Financial services | 2025 |
| Eco Logic Partners (Sunderland) Limited | Energy | 2025 |
| Eco Logic Partners Limited | Energy | 2014 |
| Eco Logic Solar Limited | Energy | 2020 |
| Eco Logic Trading Limited | Energy | 2025 |
| Eco Logic Waste Management Limited | Water & waste | 2024 |
| Eco Marketing Solutions Limited | Administrative & support | 2007 |
| Eco Mortar Limited | Construction | 2017 |
| Eco Pallets and Recycling NE Ltd | Manufacturing | 2025 |
| Eco Tech Insulation Limited | Construction | 2023 |
| Eco Trading Supplies Ltd | Administrative & support | 2019 |
| Eco-Lite Solutions Limited | Financial services | 2010 |
| Eco-Volt NE Limited | Construction | 2025 |
| Ecolution Partnership Limited | Wholesale & retail | 2020 |
| Ecomergy Holdings Limited | Professional & scientific | 2007 |
| Ecomergy Limited | Information & communication | 2007 |
| Ecomergy Powerdown.Ai Limited | Information & communication | 2009 |
| Economic Reversions Limited | Real estate | 2005 |
| Ecosafe Rubber Ltd | Wholesale & retail | 2023 |
| Ecowise Innovations Ltd | Construction | 2024 |
| ED Shearings Dog Grooming Ltd | Other services | 2024 |
| Edberts House | Health & social care | 2008 |
| Eddie's Altone Car Body Repairs Limited | Wholesale & retail | 2023 |
| Eddy Kerr Consulting Services Ltd | Professional & scientific | 2025 |
| EDELWEISS@99 Ltd | Real estate | 2022 |
| Eden Garden Nursery Limited | Education | 2006 |