| DE Africania Cash and Carry Ltd | Wholesale & retail | 2022 |
| DE Merley Properties Limited | Real estate | 2024 |
| DE Signs NE Ltd | Professional & scientific | 2022 |
| Deadbug Pest Control Ltd | Administrative & support | 2016 |
| Deals Done Ltd | Wholesale & retail | 2025 |
| Deals on Meals at Callendar CIC | Hospitality | 2024 |
| Dean (PH) Limited | Transport & logistics | 2022 |
| Dean Group NE Limited | Transport & logistics | 2019 |
| Dean Taxis Limited | Transport & logistics | 2001 |
| Deanmoor Limited | Real estate | 2002 |
| Declare Right Ltd | Professional & scientific | 2025 |
| Deeklam Limited | Hospitality | 2025 |
| Deemesh Properties Ltd | Real estate | 2025 |
| Deenhall Ltd | Real estate | 2006 |
| Deep Beauty Scuny Ltd | Other services | 2026 |
| Deer Ventures Ltd | Wholesale & retail | 2008 |
| Deerness Consulting Ltd | Professional & scientific | 2011 |
| Delhi Chaska Limited | Hospitality | 2024 |
| Delicious Churros Limited | Hospitality | 2022 |
| Delivered Safe Limited | Transport & logistics | 2018 |
| Delta Construction Ltd | Construction | 2026 |
| Delta Drainage Ltd | Water & waste | 2026 |
| Delta Home Improvements NE Ltd | Construction | 2025 |
| Deluxe Inn Ltd | Hospitality | 2024 |
| Deluxe Products Ltd | Wholesale & retail | 2023 |
| Demand Lifts Ltd | Manufacturing | 2014 |
| Demon Drillers Limited | Construction | 2008 |
| Demon Fire Stopping Limited | Professional & scientific | 2013 |
| Denbo Ltd | Real estate | 2024 |
| Dencrow Paving (NE) Ltd | Construction | 2024 |
| Dencrow Paving Limited | Construction | 2014 |
| Dendro Arboriculture Limited | Professional & scientific | 2018 |
| Denmark Foods UK Ltd | Wholesale & retail | 2013 |
| Dennison Roofing Service Ltd | Construction | 2024 |
| Dent Repair North East Ltd | Wholesale & retail | 2021 |
| Dentocandy Ltd | Education | 2025 |
| Dentprep Ltd | Health & social care | 2018 |
| Derma Dolls Ltd | Other services | 2020 |
| Dermafinity Permanent Cosmetics Ltd | Other services | 2018 |
| Derryland Limited | Real estate | 1985 |
| Derwent Manor Ventures Developments Limited | Construction | 2024 |
| Derwent Manor Ventures Limited | Real estate | 2013 |
| Derwentwater Road Social Club Limited | Hospitality | 2009 |
| Desert Live Studio Ltd | Professional & scientific | 2026 |
| Design Market Ltd | Information & communication | 2014 |
| Designed Building Solutions Ltd | Professional & scientific | 2019 |
| Designer Helmets Limited | Wholesale & retail | 2004 |
| Designer Luxury Ltd | Wholesale & retail | 2017 |
| Devenport Holdings Limited | Real estate | 2025 |
| DEW Drop Landscaping Ltd | Construction | 2024 |
| DFG Management Ltd | Real estate | 2025 |
| DH Air Ducting Ltd | Construction | 2022 |
| DH Road Works Limited | Construction | 2021 |
| DH1 Homes Ltd | Real estate | 2020 |
| DH4 Homes Ltd | Construction | 2024 |
| DH9 Ltd | Real estate | 2020 |
| Dhesi Food & Beverages Limited | Wholesale & retail | 2025 |
| Dhesi LLP | | 2025 |
| DHJ Properties (NE) Limited | Real estate | 2026 |
| DHK Leisure Limited | Hospitality | 2024 |
| Dhmrenewables Ltd | Manufacturing | 2025 |
| DHS Construction Limited | Construction | 2007 |
| DI Marco Online Limited | Wholesale & retail | 2014 |
| Diacom Sunderland Ltd | Wholesale & retail | 2018 |
| Diagnext AI Solutions Ltd | Information & communication | 2026 |
| Dial-A-Cab (Tyneside) Limited | Transport & logistics | 2002 |
| Dialect Communications Ltd | Administrative & support | 2020 |
| Diamond Build Wholesale Limited | Wholesale & retail | 2024 |
| Diamond Fit-Out Ltd | Construction | 2025 |
| Diamond Plus Research Ltd | Education | 2026 |
| Dickinson Brothers Limited | Wholesale & retail | 1936 |
| Dickinson Wildlife Ltd | Arts & recreation | 2026 |
| Didsbury Point 5 Management Limited | Households | 2005 |
| Digiconsulting Group Ltd | Administrative & support | 2021 |
| Digital Data Security Ltd | Administrative & support | 2021 |
| Digital Symmetry Ltd | Wholesale & retail | 2024 |
| Digital Transformation Research Limited | Information & communication | 2017 |
| Dingy Butterflies CIC | Arts & recreation | 2015 |
| Dinnington Stores Ltd | Wholesale & retail | 2021 |
| Dinuta Ltd | Health & social care | 2015 |
| Diostunts Ltd | Arts & recreation | 2019 |
| Direct Business Systems Limited | Other services | 1991 |
| Direct Packaging (U.K.) Ltd. | Other services | 1997 |
| Direct Wealth Consulting Limited | Financial services | 2021 |
| Dirty Hands Ltd | Professional & scientific | 2014 |
| Discount LOG Company Limited | Agriculture & fishing | 2019 |
| Discount Wine & Food Centre Ltd | Wholesale & retail | 2025 |
| Disinfect NE Ltd | Administrative & support | 2020 |
| Distilled Consultant Ltd | Professional & scientific | 2019 |
| Ditch OR Date Limited | Other services | 2004 |
| Ditchling Spirits Limited | Manufacturing | 2018 |
| DIV Ltd | Construction | 2025 |
| Diverse Minds in Engineering CIC | Education | 2026 |
| Divine Light Cosmic Healing Ltd | Health & social care | 2021 |
| Divus Limited | Manufacturing | 2013 |
| Diwasaha Ltd | Health & social care | 2022 |
| DJ Bros Ltd | Real estate | 2015 |
| DJC Contractors Limited | Other services | 2017 |
| Djms Festivals Limited | Arts & recreation | 2019 |
| DJS Locums Ltd | Health & social care | 2023 |