| ST Andrews Specsavers Limited | Wholesale & retail | 2008 |
| ST Andrews Visionplus Limited | Wholesale & retail | 2008 |
| ST Annes Specsavers Limited | Wholesale & retail | 2009 |
| ST Annes Visionplus Limited | Wholesale & retail | 2009 |
| ST Austell Specsavers Limited | Wholesale & retail | 1986 |
| ST Barbe Limited | Professional & scientific | 2018 |
| ST Clair CMC Ltd | Professional & scientific | 2021 |
| ST Cross (Osborne) Limited | Real estate | 2026 |
| ST Cross (Palmerston) Limited | Real estate | 2025 |
| ST Cross (Portland) Limited | Real estate | 2025 |
| ST Cross Homes (Eastney) Limited | Construction | 2025 |
| ST Cross Homes (Liss) Limited | Construction | 2023 |
| ST Cross Homes (Southsea) Limited | Construction | 2020 |
| ST Cross Homes Limited | Real estate | 2018 |
| ST Helens Specsavers Hearcare Limited | Wholesale & retail | 2006 |
| ST Ives Specsavers Hearcare Limited | Wholesale & retail | 2025 |
| ST Ives Specsavers Limited | Wholesale & retail | 2011 |
| ST Jobe Consulting Limited | Professional & scientific | 2019 |
| ST Neots Visionplus Limited | Wholesale & retail | 2000 |
| ST Stephens (Norwich) Specsavers Hearcare Limited | Wholesale & retail | 2019 |
| ST Stephens Visionplus Limited | Wholesale & retail | 2012 |
| ST Thomas House Management Company Limited | Households | 2004 |
| ST. Austell Visionplus Limited | Wholesale & retail | 1994 |
| ST. George's Court Management (Fareham) Limited | Hospitality | 1990 |
| Stacey's Sarnies Limited | Hospitality | 2024 |
| Stackforce UK Ltd | Information & communication | 2025 |
| Stafford Specsavers Hearcare Limited | Wholesale & retail | 2019 |
| Stafford Visionplus Limited | Wholesale & retail | 1990 |
| Stagstone Limited | Real estate | 2025 |
| Staines Specsavers Hearcare Limited | Wholesale & retail | 2006 |
| Staines Specsavers Limited | Wholesale & retail | 1999 |
| Staines Visionplus Limited | Wholesale & retail | 1999 |
| Stallion Finance Ltd | Administrative & support | 2021 |
| Stalwart Solicitors Ltd | Professional & scientific | 2019 |
| Stamford Morrisons Specsavers Limited | Wholesale & retail | 2002 |
| Stamshaw Garages (Portsmouth) Limited | Real estate | 1968 |
| Standplane Limited | Construction | 2002 |
| Stanford James Associates Limited | Administrative & support | 2016 |
| Stanley Specsavers Limited | Wholesale & retail | 2018 |
| Stanmore Specsavers Limited | Wholesale & retail | 2016 |
| Stansted Shopfitters UK Ltd | Construction | 2015 |
| Stanstock Limited | Administrative & support | 2024 |
| Stanton Psychological Services Limited | Professional & scientific | 2009 |
| Stanway Specsavers Limited | Wholesale & retail | 2018 |
| Star Beauty Nails Limited | Other services | 2022 |
| Star Connection Services Limited | Construction | 2023 |
| Star Maintenance Ltd | Construction | 1997 |
| Stardust New Forest Ltd | Professional & scientific | 2024 |
| Starling Maxted Ltd | Professional & scientific | 2024 |
| Starling Systems Limited | Information & communication | 2016 |
| Stars and Stripes Management Limited | Arts & recreation | 2017 |
| Stary Tradehub (UK) Ltd | Wholesale & retail | 2024 |
| Starz Ballet Babes LLP | | 2015 |
| Starz Enterprise Ltd | Other services | 2017 |
| Stata Integrated Systems Limited | Public administration | 2023 |
| Statebound Ltd | Arts & recreation | 2024 |
| Stather Solutions Limited | Information & communication | 2018 |
| Station Body Shop Limited | Manufacturing | 2013 |
| Status GAS Ltd | Manufacturing | 2020 |
| Staunton Estates Limited | Construction | 1957 |
| Stayintheday Ltd | Professional & scientific | 2020 |
| Staywight Roofline Ltd | Construction | 2026 |
| Steadfast Ignition UK Ltd | Wholesale & retail | 2023 |
| Steadfast Investments Ltd | Professional & scientific | 2016 |
| Stealth Interiors Limited | Construction | 2004 |
| Steddio Limited | Other services | 2018 |
| Steels Online Limited | Wholesale & retail | 2023 |
| Steeple Repairs Limited | Other services | 2019 |
| Steer Drive Limited | Administrative & support | 2010 |
| Stefan BUD Ltd | Transport & logistics | 2014 |
| Stefoto Ltd | Wholesale & retail | 2024 |
| Stellamar Limited | Information & communication | 2011 |
| Stellar Business Services Ltd. | Transport & logistics | 2007 |
| Stellar Despatch Services Limited | Transport & logistics | 2008 |
| Stem Electronics Limited | Other services | 2020 |
| Stenning GAS Services Limited | Professional & scientific | 2018 |
| Stenning Taphouse's Ltd | Hospitality | 2021 |
| Step Forward Mentoring Ltd | Education | 2023 |
| Stephen's Barbers Limited | Other services | 2003 |
| Steppin' UP Dance CIC | Arts & recreation | 2024 |
| Steps to Talking Ltd | Health & social care | 2019 |
| Sterling Construction Group Ltd | Construction | 2023 |
| Sterling Financial Consultants Limited | Financial services | 2000 |
| Sterling Pools Ltd | Construction | 2020 |
| Sterlingcrest Associates Ltd | Financial services | 2020 |
| Steve Claridge Limited | Real estate | 2014 |
| Steven Rogers Landscapes Limited | Administrative & support | 2024 |
| Stevenage Poplars Specsavers Limited | Wholesale & retail | 2017 |
| Stevenage Specsavers Hearcare Limited | Wholesale & retail | 2023 |
| Stevenage Specsavers Limited | Wholesale & retail | 1992 |
| Stevenage Visionplus Limited | Wholesale & retail | 1992 |
| Steward Marshall Homes Ltd | Real estate | 2025 |
| Stfw Electrical Ltd | Construction | 2022 |
| Still Studio Ltd | Professional & scientific | 2025 |
| Stirling Metro-Rail Limited | Administrative & support | 1997 |
| Stirling Specsavers Limited | Wholesale & retail | 1993 |
| Stirling Visionplus Limited | Wholesale & retail | 1993 |
| Stirling Works Global Ltd | Professional & scientific | 2017 |
| Stitch Industries Ltd | Information & communication | 2026 |
| STJ Transportation Ltd | Transport & logistics | 2017 |