| Stjohn's Security Liaisons (SSL) Limited | Administrative & support | 2021 |
| STM Healthcare Ltd | Administrative & support | 2015 |
| STN Solutions (Holdings) Limited | Financial services | 2022 |
| STN Solutions Ltd | Construction | 2008 |
| Stockport Specsavers Hearcare Limited | Wholesale & retail | 2007 |
| Stockport Specsavers Limited | Wholesale & retail | 1997 |
| Stockport Visionplus Limited | Wholesale & retail | 1997 |
| Stockton Specsavers Hearcare Limited | Wholesale & retail | 2013 |
| Stoke Retail Ltd | Wholesale & retail | 2025 |
| Stoke-On-Trent Domi Audiology Specsavers Limited | Wholesale & retail | 2024 |
| Stoked Food Ltd | Manufacturing | 2015 |
| Stoked Watersports Ltd | Arts & recreation | 2024 |
| Stone Anchor Property Ltd | Hospitality | 2025 |
| Stone Specsavers Limited | Wholesale & retail | 2018 |
| Stonecrest Investments Limited | Financial services | 2024 |
| Stonehaven Specsavers Limited | Wholesale & retail | 2009 |
| Stonequay Developments Ltd | Construction | 2026 |
| Stones Throw Kitchen Ltd | Hospitality | 2021 |
| Stonesafe Talent Limited | Administrative & support | 2026 |
| Storage Unlimited Ltd | Other services | 2018 |
| Storerne Ltd | Information & communication | 2026 |
| Stork Elastomeric Services Limited | Professional & scientific | 2021 |
| Storm Growth Marketing Limited | Professional & scientific | 2025 |
| Stormont Design Ltd | Other services | 2018 |
| Stormont Estate Services Limited | Real estate | 2022 |
| Stourbridge Specsavers Hearcare Limited | Wholesale & retail | 2024 |
| Stourbridge Visionplus Limited | Wholesale & retail | 1990 |
| Stourport-On-Severn Specsavers Limited | Wholesale & retail | 2002 |
| Stowmarket Specsavers Limited | Wholesale & retail | 2002 |
| STP Southern Limited | Extraterritorial | 2016 |
| Straight Talk Mortgages Limited | Financial services | 2025 |
| Straiton Specsavers Limited | Wholesale & retail | 2018 |
| Strand Harbour Securities Limited | Real estate | 1987 |
| Strand Specsavers Limited | Wholesale & retail | 2009 |
| Strands Hairdressing (Whiteley) Limited | Other services | 2022 |
| Stranraer Specsavers Limited | Wholesale & retail | 2008 |
| Stranraer Visionplus Limited | Wholesale & retail | 2008 |
| Stratex Exploration Limited | Mining & quarrying | 2004 |
| Stratex West Africa Limited | Mining & quarrying | 2007 |
| Stratford Specsavers Limited | Wholesale & retail | 1995 |
| Stratford Visionplus Limited | Wholesale & retail | 2001 |
| Stratford-Upon-Avon Specsavers Hearcare Limited | Wholesale & retail | 2013 |
| Stratford-Upon-Avon Specsavers Limited | Wholesale & retail | 1995 |
| Stratford-Upon-Avon Visionplus Limited | Wholesale & retail | 1995 |
| Stratovix Ltd | Professional & scientific | 2025 |
| Stratton Specsavers Limited | Wholesale & retail | 2018 |
| Stratum Search & Selection Limited | Administrative & support | 2009 |
| Strawberry Fields Farm Ltd | Agriculture & fishing | 2024 |
| Straya Properties Ltd | Construction | 2024 |
| Stream Group Limited | Other services | 2021 |
| Stream Salon Limited | Other services | 2025 |
| Streamsoft Development Ltd | Information & communication | 2018 |
| Streatham Specsavers Limited | Wholesale & retail | 1992 |
| Streatham Visionplus Limited | Wholesale & retail | 1992 |
| Street GAS Ltd | Construction | 2021 |
| Street Place Holdings Ltd | Agriculture & fishing | 2025 |
| Street Specsavers Limited | Wholesale & retail | 2002 |
| Stretch Ceilings Limited | Construction | 1998 |
| Stretford Specsavers Limited | Wholesale & retail | 1993 |
| Stride Close (Freehold) Limited | Households | 2004 |
| Stringers Property Management Ltd | Real estate | 2025 |
| Stronghold Direct Ltd | Wholesale & retail | 2016 |
| Strood Specsavers Limited | Wholesale & retail | 2017 |
| Stroud Specsavers Limited | Wholesale & retail | 1993 |
| Stroud Visionplus Limited | Wholesale & retail | 1993 |
| Structural Intelligence Limited | Professional & scientific | 2016 |
| Structured Home Learning Limited | Education | 2008 |
| STS Tradesman Services Limited | Construction | 2026 |
| STS Training Limited | Education | 2012 |
| Stuart Forster (UK) Limited | Other services | 2021 |
| Stuart Forster Holdings Limited | Financial services | 2024 |
| Stuart Independent Spirits Ltd | Hospitality | 2000 |
| Stubbington Carpentry Ltd | Manufacturing | 2023 |
| Stubbington Carpets Limited | Wholesale & retail | 2009 |
| Stubbington Electrical Ltd | Construction | 2015 |
| Stubbington Indian Resturent Limited | Hospitality | 2025 |
| Stubbington Natural Health Clinic Ltd | Real estate | 2013 |
| Stubbington Plumbing and Heating Ltd | Construction | 2017 |
| Stubbington Roofing Limited | Construction | 2015 |
| Stubbington Springboard Gymnastics Club Ltd | Arts & recreation | 2014 |
| Stubbington Tree Care Ltd | Administrative & support | 2013 |
| Stubbington Village Pets Limited | Wholesale & retail | 2014 |
| Student Castle Developments Limited | Construction | 2014 |
| Student Castle Investments Holdco Limited | Financial services | 2018 |
| Student Castle Property Management Services Limited | Real estate | 2010 |
| Student Rooms 2 LET Ltd | Administrative & support | 2022 |
| Studio Incar Ltd | Wholesale & retail | 2019 |
| Studio Norris Ltd | Other services | 2025 |
| Studio Savvi Limited | Information & communication | 2012 |
| Studio Unique Ltd | Education | 2026 |
| Stuti Bhatt Ltd | Health & social care | 2016 |
| STY918 Ltd | Hospitality | 2022 |
| Style Studio (Rowlands Castle) Limited | Other services | 2006 |
| Suarez&Suarez Ltd | Real estate | 2024 |
| Subtotem Ltd | Information & communication | 2026 |
| Success Nations Limited | Financial services | 2020 |
| Sudbury Cornard Road Specsavers Limited | Wholesale & retail | 2018 |
| Sudbury Specsavers Limited | Wholesale & retail | 2003 |
| Sudbury Visionplus Limited | Wholesale & retail | 2003 |
| SUE Wassall Limited | Wholesale & retail | 2012 |