| Southern Surfacing Solutions Limited | Transport & logistics | 2013 |
| Southern Valley Construction Ltd | Construction | 2019 |
| Southern Van Locks Ltd | Administrative & support | 2023 |
| Southern Volumetric Concrete Ltd | Manufacturing | 2020 |
| Southern Wealth Associates Limited | Professional & scientific | 2015 |
| Southern Window Installations Limited | Construction | 2010 |
| Southpac Freight Services Ltd | Transport & logistics | 2016 |
| Southport Specsavers Hearcare Limited | Wholesale & retail | 2003 |
| Southsea Visionplus Limited | Wholesale & retail | 2000 |
| Southview Care Services Limited | Health & social care | 2025 |
| Southways Automotive Ltd | Wholesale & retail | 2009 |
| Southwell Building Services Limited | Construction | 2001 |
| Southwest Shipyard Limited | Real estate | 2020 |
| Southwick Estate Enterprises LLP | | 2017 |
| Southwick Forestry Limited | Agriculture & fishing | 2013 |
| Southwick Landscape Services Ltd | Administrative & support | 2026 |
| Southwick Park Golf Club Ltd | Other services | 2010 |
| Southwick Village Stores Limited | Wholesale & retail | 2017 |
| Southwick Vineyards Ltd | Agriculture & fishing | 2026 |
| SP Retail Investment Limited | Wholesale & retail | 2019 |
| Spa Shield Ltd | Administrative & support | 2026 |
| Spa-Espana Limited | Wholesale & retail | 2013 |
| SPACE2BE Limited | Professional & scientific | 2013 |
| Spade & Fork Cafe Limited | Hospitality | 2017 |
| Spalding Specsavers Hearcare Limited | Wholesale & retail | 2024 |
| Spalding Specsavers Limited | Wholesale & retail | 2006 |
| Spalding Visionplus Limited | Wholesale & retail | 2006 |
| Span House Films Ltd | Information & communication | 2024 |
| Spares Distribution Ltd | Wholesale & retail | 2025 |
| SPARES2REPAIR Ltd | Wholesale & retail | 2016 |
| Spark & Structure Ltd | Construction | 2026 |
| Spark Care UK Ltd | Health & social care | 2018 |
| Spark Emerging Technologies Ltd | Information & communication | 2005 |
| Sparkle Bay Ltd | Administrative & support | 2025 |
| Sparkling Canines Ltd | Other services | 2023 |
| Sparks of Joy Ltd | Arts & recreation | 2019 |
| Sparks Two Ltd | Real estate | 2020 |
| Sparqui Solutions Ltd | Information & communication | 2025 |
| Sparta Interiors Ltd | Construction | 2024 |
| Special Vehicle Works Ltd. | Other services | 2019 |
| Specialist AV Ltd | Administrative & support | 2025 |
| Specialist Flying Mentors Limited | Professional & scientific | 2025 |
| Specialist Marketing Experts Limited | Other services | 2017 |
| Specialized Fabrications Limited | Construction | 1997 |
| Specialized LED Ltd | Wholesale & retail | 2025 |
| Speck-Tacular Castles Ltd | Administrative & support | 2025 |
| Specsavers EYE Care Services Limited | Health & social care | 2016 |
| Specsavers Fulfilment Services UK Limited | Wholesale & retail | 1989 |
| Specsavers Healthcall Limited | Health & social care | 1991 |
| Specsavers Hearcare Limited | Wholesale & retail | 1998 |
| Specsavers Optical Superstores Limited | Construction | 1983 |
| Specsavers Procurement UK Limited | Wholesale & retail | 2010 |
| Specsavers Recruitment Services Limited | Extraterritorial | 2011 |
| Specsavers UK Holdings Limited | Financial services | 2017 |
| Specsavers UK Limited | Extraterritorial | 1986 |
| Spectre Global Limited | Information & communication | 2023 |
| Speed Star Promotions Limited | Arts & recreation | 2025 |
| Sphere Guardian Limited | Professional & scientific | 2003 |
| Spice Fareham Ltd | Hospitality | 2022 |
| Spice PUB Ltd | Hospitality | 2020 |
| Spiff Transport Ltd | Transport & logistics | 2024 |
| Spike Consulting Services Ltd | Professional & scientific | 2025 |
| Spindrift Motorsport Ltd | Information & communication | 2026 |
| Spinnaker Electronic Assembly Ltd | Manufacturing | 2009 |
| Spinnaker IP Limited | Professional & scientific | 2015 |
| Spinnaker Property Management & Development Ltd | Households | 2022 |
| Spiny Norman Limited | Information & communication | 2019 |
| Spiro Accounting Ltd | Professional & scientific | 2016 |
| Spitfire Electrical Services Ltd | Administrative & support | 2013 |
| Spitfire Marketing Limited | Professional & scientific | 2008 |
| Spitfire Renewable Energies Limited | Construction | 2024 |
| Splish Splash Pools Limited | Administrative & support | 2016 |
| Spokido Management Limited | Professional & scientific | 2015 |
| Sport Science Podiatry Ltd | Health & social care | 2022 |
| Sporting Highlights Ltd | Administrative & support | 2023 |
| Sporting Partnerships Financial Services Limited | Financial services | 2013 |
| Sportsnetsuk Ltd | Arts & recreation | 2021 |
| Spotlight Consultations Ltd | Health & social care | 2020 |
| Spotty Badger Ltd | Hospitality | 2021 |
| Spray Foam Removers Limited | Administrative & support | 2023 |
| Spring Road Management Limited | Real estate | 1986 |
| Springfield Specsavers Limited | Wholesale & retail | 2018 |
| SPS Publicans Ltd | Hospitality | 2018 |
| Spytty Road Specsavers Limited | Wholesale & retail | 2011 |
| Square & Compass Construction Ltd | Real estate | 2018 |
| Square Communications Limited | Professional & scientific | 2017 |
| Square One Hospitality Ltd | Professional & scientific | 2025 |
| Squareone Music Limited | Wholesale & retail | 2026 |
| SRC (Hampshire) Limited | Construction | 2018 |
| SRS Learning Limited | Education | 2014 |
| SRS Project Services Ltd | Construction | 2021 |
| SS Intec Ltd | Professional & scientific | 2021 |
| SSH Electrical Ltd | Construction | 2016 |
| SSL Construction Ltd | Construction | 2019 |
| SSN Fire and Security Limited | Administrative & support | 2018 |
| SSP Bhatt Limited | Health & social care | 2022 |
| Ssports Ltd | Education | 2025 |
| SST Motors Limited | Wholesale & retail | 2018 |
| ST Albans Everard Specsavers Limited | Wholesale & retail | 2022 |
| ST Albans Specsavers Hearcare Limited | Wholesale & retail | 2007 |