| Solo Superia Limited | Wholesale & retail | 2014 |
| Solo Topco Limited | Financial services | 2019 |
| Soluna Lettings Ltd | Real estate | 2020 |
| Solution IP Communications Limited | Information & communication | 2007 |
| Solution-I Design Limited | Information & communication | 2004 |
| SOLUTIONS321 Ltd | Administrative & support | 2024 |
| Soluxion Ltd. | Information & communication | 2001 |
| Solveware Engineering Ltd | Information & communication | 2018 |
| Something Music Limited | Information & communication | 1991 |
| Sommers Books Ltd. | Information & communication | 2017 |
| SON Smile Ltd | Health & social care | 2021 |
| Sonosound Scanning Ltd | Health & social care | 2026 |
| Sorb Limited | Professional & scientific | 2022 |
| Sorel Jane Trading Ltd | Other services | 2019 |
| SOS Doctors Ltd | Health & social care | 2024 |
| SOS Fareham Ltd | Hospitality | 2025 |
| SOS Optical Ltd | Wholesale & retail | 2020 |
| SOS Therapies Ltd | Health & social care | 2024 |
| Soscollectible Ltd | Wholesale & retail | 2024 |
| Sota Electrical Ltd | Manufacturing | 2013 |
| Soteria Safety Engineering Limited | Professional & scientific | 2024 |
| Sound Rooms Ltd | Education | 2019 |
| Sourced by Selecta Ltd | Wholesale & retail | 2025 |
| Sourcific Talent Limited | Administrative & support | 2018 |
| South Central Distribution Ltd | Administrative & support | 2013 |
| South Coast Advertising Ltd | Manufacturing | 2019 |
| South Coast Belting Limited | Real estate | 2020 |
| South Coast Boiler Replacements Ltd | Construction | 2019 |
| South Coast Charters Limited | Administrative & support | 2024 |
| South Coast CKD Ltd | Health & social care | 2015 |
| South Coast Commercial Cleaning Group Ltd | Administrative & support | 2022 |
| South Coast Construction Ltd. | Construction | 1998 |
| South Coast Expert Builders Ltd | Construction | 2019 |
| South Coast Fatigue Limited | Health & social care | 2009 |
| South Coast First AID Ltd | Education | 2022 |
| South Coast Flooring Limited | Construction | 2019 |
| South Coast Local Builders Ltd | Construction | 2019 |
| South Coast Logistics Limited | Hospitality | 2021 |
| South Coast Pumping Solutions Ltd | Professional & scientific | 2025 |
| South Coast Renewable Energy Ltd | Energy | 2019 |
| South Coast Sweets Ltd | Wholesale & retail | 2025 |
| South Coast Symphonia Limited | Education | 2011 |
| South Coast Tail Lift Repairs Limited | Manufacturing | 2002 |
| South Coast Vapour Blasting Ltd | Manufacturing | 2025 |
| South Coast Workboats Limited | Administrative & support | 2017 |
| South Downs Linen Ltd | Administrative & support | 2023 |
| South Downs Meadow Ltd | Professional & scientific | 2024 |
| South Downs Property Limited | Real estate | 2025 |
| South Downs Removals Ltd | Transport & logistics | 2024 |
| South East Arborists Ltd | Agriculture & fishing | 2020 |
| South East Trenching Limited | Construction | 2002 |
| South Elmsall Specsavers Limited | Wholesale & retail | 2017 |
| South Hampshire College Group Limited | Wholesale & retail | 1994 |
| South Hants Couriers Limited | Transport & logistics | 2019 |
| South Harrow Specsavers Hearcare Limited | Wholesale & retail | 2025 |
| South Harrow Specsavers Limited | Wholesale & retail | 2006 |
| South Harrow Visionplus Limited | Wholesale & retail | 2006 |
| South Leigh Construction Ltd | Construction | 2022 |
| South Leigh Enterprises Limited | Administrative & support | 2023 |
| South West Motors Limited | Wholesale & retail | 1983 |
| South Woodham Ferrers Specsavers Limited | Wholesale & retail | 2018 |
| South Yorkshire Domi Audiology Specsavers Limited | Wholesale & retail | 2023 |
| Southampton Carpentry Ltd | Manufacturing | 2021 |
| Southampton CC Specsavers Hearcare Limited | Wholesale & retail | 2022 |
| Southampton Electrical Limited | Construction | 2018 |
| Southampton Marine Services Limited | Manufacturing | 2016 |
| Southampton Port Partnership Limited | Administrative & support | 2006 |
| Southampton Specsavers Hearcare Limited | Wholesale & retail | 2005 |
| Southampton Specsavers Limited | Wholesale & retail | 1987 |
| Southampton Steel Industrial Services Limited | Water & waste | 2025 |
| Southampton Visionplus Limited | Wholesale & retail | 1998 |
| Southcoast Brickwork Solutions Limited | Construction | 2026 |
| Southcoast Fibreglass Supplies Limited | Wholesale & retail | 2015 |
| Southdown Property Group Ltd | Construction | 2026 |
| Southdowns Drinks Ltd | Administrative & support | 2020 |
| Southdowns GAS Ltd | Construction | 2020 |
| Southdowns Logistics Ltd | Transport & logistics | 2025 |
| Southend Specsavers Hearcare Limited | Wholesale & retail | 2003 |
| Southern Alehouse Ltd | Hospitality | 2019 |
| Southern Arboriculture Ltd | Agriculture & fishing | 2019 |
| Southern Autolocks Ltd | Wholesale & retail | 2015 |
| Southern Automotive Locksmiths Ltd | Manufacturing | 2021 |
| Southern Automotive Solutions Limited | Wholesale & retail | 2023 |
| Southern Autosport Association Limited | Arts & recreation | 1976 |
| Southern Bathroom Installations Ltd | Construction | 2023 |
| Southern Canine Imaging Ltd | Professional & scientific | 2012 |
| Southern Canopy Sales & Hire Ltd | Wholesale & retail | 2009 |
| Southern Fabrications (Sussex) Limited | Other services | 2007 |
| Southern Laser Cutting Ltd | Manufacturing | 2024 |
| Southern Marquees Limited | Administrative & support | 2001 |
| Southern Oak Frames Ltd | Construction | 2026 |
| Southern Plumbing Supplies Ltd | Wholesale & retail | 2018 |
| Southern Sealants Limited | Construction | 2010 |
| Southern Security Services Limited | Administrative & support | 1983 |
| Southern Security Solution Ltd | Administrative & support | 2020 |
| Southern Shores Ltd | Real estate | 2021 |
| Southern Sky Group Ltd | Professional & scientific | 2024 |
| Southern Sky Limited | Professional & scientific | 2006 |
| Southern Solutions UK Limited | Information & communication | 2008 |
| Southern Stronghold Limited | Wholesale & retail | 1990 |