| SA Autos & Recovery Ltd | Transport & logistics | 2023 |
| SA Relocation Limited | Real estate | 2013 |
| SA Thorverton Arms Lodgings Ltd | Hospitality | 2024 |
| SA Thorverton Arms Ltd | Hospitality | 2022 |
| SA White Lion Ltd | Hospitality | 2024 |
| Saas Brella Ltd | Information & communication | 2018 |
| Sabaidee Property Ltd | Financial services | 2025 |
| SAC Cars & Aviation Ltd | Administrative & support | 2014 |
| Sacred Grounds (Exeter) Ltd | Hospitality | 2018 |
| Sadborow Estate Limited | Real estate | 1937 |
| Sadborow Property Company | Real estate | 2020 |
| Sadborow Solar Ltd | Energy | 2014 |
| Sadborow Trust Company | Financial services | 2010 |
| Sadborow Trust Company Holdings | Financial services | 2013 |
| Saddles & Paddles Exeter Ltd | Manufacturing | 2012 |
| Safe Forks Limited | Construction | 2021 |
| Safe Foundation | Health & social care | 1984 |
| Safe Hands Register Ltd | Other services | 2025 |
| Safe Space Technology Ltd | Information & communication | 2020 |
| Safeguard Hampshire Limited | Construction | 2006 |
| Safeguarding on Spiking Limited | Health & social care | 2002 |
| Safeheat Homecover Limited | Other services | 2015 |
| Safelec (Exeter) Ltd | Manufacturing | 2022 |
| Safenetz (UK) Limited | Construction | 2016 |
| Safety Direct H&S Management Ltd | Other services | 2016 |
| Safetydirectgroup Ltd | Other services | 2012 |
| Safran (South West) Limited | Financial services | 2003 |
| Sage & Greens CIC | Agriculture & fishing | 2026 |
| Sage Nootropics Limited | Manufacturing | 2025 |
| SAH Bespoke Ltd | Wholesale & retail | 2024 |
| Sailexmouth.Com Limited | Arts & recreation | 2008 |
| Sailtime Poole Limited | Hospitality | 2006 |
| Saint Anthony Charcuterie Ltd | Manufacturing | 2020 |
| Saint Luxury Services Limited | Wholesale & retail | 2026 |
| Sainthill House Ltd | Health & social care | 2009 |
| SAJ (UK) Limited | Hospitality | 2004 |
| SAL Properties & Investments Limited | Real estate | 2019 |
| Saladoux Ltd | Hospitality | 2026 |
| Salami Steve Limited | Manufacturing | 2024 |
| Salarity Ltd | Professional & scientific | 2025 |
| Salisbury Brewery Limited | Manufacturing | 2016 |
| Salmon Pool Court (Exeter) Residents Association Limited | Households | 1965 |
| Salon 202 Limited | Other services | 2021 |
| Salston Associates Limited | Professional & scientific | 2004 |
| Salt & Spoon Limited | Administrative & support | 2019 |
| Salt & Vinegar Catering Limited | Hospitality | 2020 |
| Salt + Land Ltd | Professional & scientific | 2015 |
| Salt Beef Limited | Administrative & support | 2009 |
| Salt Builds Ltd | Construction | 2026 |
| Saltash Barbers Ltd | Other services | 2022 |
| Salter Roofing Limited | Construction | 1995 |
| Saltmarsh Environmental Limited | Professional & scientific | 2025 |
| Salutary Solutions Limited | Professional & scientific | 2011 |
| SAM Gilpin Demolition Limited | Construction | 1999 |
| SAM Hill Coaching Ltd | Arts & recreation | 2023 |
| SAM SLY Limited | Public administration | 2022 |
| Sambac Holdings Limited | Health & social care | 2026 |
| Samlove Care Ltd | Health & social care | 2025 |
| Samuel Farmer & Co Ltd | Manufacturing | 2011 |
| Samuel Group Investments Limited | Financial services | 2025 |
| Samuels Estate Agents Limited | Real estate | 2009 |
| Sanctuary Eight Limited | Other services | 2026 |
| Sandbanks Group Holdings Limited | Financial services | 2021 |
| Sandboy Limited | Information & communication | 1996 |
| Sanders LEA Management Company Limited | Households | 2019 |
| Sanderson Communications Limited | Professional & scientific | 2013 |
| Sandhill Park (the Courtyard) Management Company Limited | Households | 2022 |
| Sanditon Properties Limited | Hospitality | 2021 |
| Sanditone Limited | Health & social care | 2015 |
| Sandle Nash Holdings Limited | Financial services | 2020 |
| Sandle Nash Limited | Financial services | 2011 |
| Sands & Partners Limited | Financial services | 2021 |
| Sandy Park Hotel Limited | Hospitality | 2017 |
| Sangani Limited | Health & social care | 2021 |
| Sangfroid Group Ltd | Administrative & support | 2022 |
| Sangfroid Holdings Ltd | Financial services | 2024 |
| Sangfroid Resources Ltd | Administrative & support | 2023 |
| Sanitas Communications Ltd | Professional & scientific | 2021 |
| Sanskrit Holdings Ltd | Real estate | 2017 |
| Sansom Construction Group Ltd | Construction | 2005 |
| Santos KAY Limited | Information & communication | 2008 |
| Sanwei Limited | Professional & scientific | 2005 |
| SAP Projects Ltd | Information & communication | 2009 |
| Sapiego Ltd | Extraterritorial | 2020 |
| Sapientia Legal Costs Consulting Limited | Professional & scientific | 2017 |
| Sapio Consulting Ltd | Administrative & support | 2020 |
| Sapphic Women’S Escapes Ltd | Administrative & support | 2026 |
| Sapphire Kitchens Limited | Construction | 2011 |
| Sapphire Spaces Limited | Wholesale & retail | 2010 |
| Sapphire Sun Limited | Financial services | 2025 |
| SAR One LLP | | 2024 |
| Sarah Thorne Limited | Wholesale & retail | 2005 |
| Sarah Turner Ltd | Health & social care | 2026 |
| Sargent & Sons Limited | Wholesale & retail | 2003 |
| Sark South West Limited | Health & social care | 2022 |
| Saros 43 RTM Ltd | Real estate | 2011 |
| SAS (Europe) Limited | Wholesale & retail | 2001 |
| SAS Carpentry Services Limited | Construction | 2009 |
| Sasamat Limited | Real estate | 2020 |
| Satchel Design Company Limited | Manufacturing | 1996 |