| Rubicon Research Limited | Professional & scientific | 2002 |
| Ruby Medical Ltd | Health & social care | 2024 |
| Ruby's Care in the Community Limited | Health & social care | 2021 |
| Rudbaxton Solar Park Limited | Energy | 2012 |
| Ruddlesden Geotechnical Ltd | Professional & scientific | 2004 |
| Rugby Events Ltd | Hospitality | 2024 |
| Ruha Limited | Hospitality | 2013 |
| Rule 3 Consulting Ltd | Public administration | 2018 |
| Rumori Enterprises Ltd | Financial services | 2023 |
| Rumours (Exeter) Ltd | Hospitality | 2025 |
| Runcom Digital Limited | Information & communication | 2010 |
| Runogames Ltd | Information & communication | 2024 |
| Runway Creative Limited | Professional & scientific | 2012 |
| Runwick Roastery Limited | Wholesale & retail | 2014 |
| Rupert Egerton-Smith Consulting Limited | Professional & scientific | 2018 |
| Rupert Newman Ltd | Arts & recreation | 2015 |
| Rural Life Developments Limited | Construction | 2005 |
| Rush Group Limited | Wholesale & retail | 1990 |
| Rush Property Group Limited | Construction | 2023 |
| Rush Retail Limited | Wholesale & retail | 2021 |
| Rushmere Investment Properties Limited | Real estate | 2016 |
| Rushmoor Knights Academy Ltd | Arts & recreation | 2023 |
| Russ Build Ltd | Construction | 2025 |
| Russ Groundwork Limited | Construction | 2018 |
| Russell & Young Construction Ltd | Hospitality | 2018 |
| Russell & Young Ltd | Professional & scientific | 2011 |
| Russell Nash Consultants Limited | Extraterritorial | 1995 |
| Russell Osborn Limited | Professional & scientific | 1997 |
| Russell Way Management Company Limited | Households | 2006 |
| Russett Holdings Ltd | Construction | 2021 |
| Rust Never Sleeps Ltd | Real estate | 2014 |
| RVR Holdings Limited | Financial services | 2026 |
| RVW PH Limited | Hospitality | 2016 |
| RWJ Properties Ltd | Real estate | 2021 |
| Rx-Info Holdings Limited | Information & communication | 2018 |
| Rx-Info Limited | Information & communication | 2003 |
| Ryan Properties Limited | Real estate | 1990 |
| Ryders Homemade Bakery Ltd | Manufacturing | 2011 |
| Rydon Hill Holdings Limited | Financial services | 2025 |
| Rydon Property Ltd | Real estate | 2025 |
| Rydon Signs Limited | Manufacturing | 1979 |
| Rydon Signs Trading Limited | Financial services | 2022 |
| Ryno Logistics (Devon) Ltd | Transport & logistics | 2021 |
| Ryno Logistics Ltd | Transport & logistics | 2014 |
| RZR Groundworks Ltd | Construction | 2025 |
| S & a Smith Limited | Other services | 2015 |
| S & E LA Spezia Ltd | Hospitality | 2018 |
| S & G Carpets Limited | Construction | 2003 |
| S & H Kernow Ltd | Construction | 2021 |
| S & M Carpentry and Building Limited | Manufacturing | 2022 |
| S & M Power Factory Ltd | Wholesale & retail | 2019 |
| S & M Residential Limited | Real estate | 2019 |
| S & S Southern Building and Mechanical Limited | Construction | 2017 |
| S a F Exeter Ltd | Professional & scientific | 2023 |
| S a Rayner Limited | Professional & scientific | 2025 |
| S B Precision Engineering Ltd | Professional & scientific | 2012 |
| S B R Property Services Ltd | Construction | 2011 |
| S Banks Assets Ltd | Real estate | 2026 |
| S C C (Exeter) Limited | Other services | 2000 |
| S C Evans (Hillcrest View) Limited | Construction | 2023 |
| S C Evans Developments Limited | Construction | 2019 |
| S C Plain Limited | Construction | 2002 |
| S C Rolfe Heating Services Ltd | Construction | 2025 |
| S Creative Marketing Limited | Professional & scientific | 2015 |
| S D Turner & Sons Ltd | Construction | 2022 |
| S Hardy Scaffolding Ltd | Construction | 2017 |
| S Jarman Plumbing, Heating & Building Services Ltd | Construction | 2019 |
| S Joy Ltd | Wholesale & retail | 2024 |
| S L Kershaw Limited | Wholesale & retail | 2026 |
| S L Storage Limited | Transport & logistics | 2016 |
| S M Hawkins Ltd | Administrative & support | 2015 |
| S Munisamy Ltd | Health & social care | 2023 |
| S N Khan Ltd | Health & social care | 2007 |
| S P Osprey Limited | Real estate | 2022 |
| S P W Powne ET AL Limited | Professional & scientific | 2003 |
| S Smith & Sons Carpets Limited | Construction | 2002 |
| S T Kingston Ltd | Professional & scientific | 2016 |
| S Taylor Farming Ltd | Agriculture & fishing | 2018 |
| S W R Consulting Limited | Professional & scientific | 2024 |
| S W Range Solutions Ltd | Manufacturing | 2025 |
| S&D Avanti Ltd | Real estate | 2024 |
| S&G Plastering Ltd | Construction | 2024 |
| S&K Delight Ltd | Hospitality | 2021 |
| S&S Logisticss Limited | Transport & logistics | 2025 |
| S. B. E. Finance Limited | Real estate | 2023 |
| S. B. E. Property Services Ltd | Real estate | 2023 |
| S. J. Ward Refrigeration Ltd | Construction | 2015 |
| S. Notaro Property Limited | Real estate | 2001 |
| S.D.C. Manufacturing Limited | Manufacturing | 1992 |
| S.F.Me Ltd | Transport & logistics | 2024 |
| S.P.A. SW Ltd | Wholesale & retail | 2024 |
| S.P.B SW Ltd | Wholesale & retail | 2024 |
| S.P.S Energy Limited | Wholesale & retail | 2014 |
| S.T. & A.L. Ward Ltd | Agriculture & fishing | 2006 |
| S.W. Slating and Tiling Limited | Construction | 1979 |
| S.W.W Commercial Plumbing & Heating Ltd | Construction | 2021 |
| S.W.W Domestic Plumbing and Heating Ltd | Other services | 2022 |
| S206 Studio Ltd | Information & communication | 2024 |
| S2T Unlocking Cyberspace Limited | Wholesale & retail | 2020 |
| S88OBR Limited | Financial services | 2024 |