| Satinsilk Limited | Agriculture & fishing | 1998 |
| Sativa Spirits Limited | Extraterritorial | 2019 |
| Savage Rose Tattoos Ltd | Arts & recreation | 2021 |
| Savanna Developments Limited | Construction | 2023 |
| Save Exeter Cathedral School Ltd | Arts & recreation | 2009 |
| Save on Tyres Devon Limited | Wholesale & retail | 2019 |
| Savs Consulting Ltd | Information & communication | 2019 |
| Sawa Engineering Limited | Wholesale & retail | 2007 |
| Saxon Bower Ltd | Construction | 2013 |
| Saxon Walk Management Limited | Real estate | 2001 |
| Sayed Computer UK Limited | Wholesale & retail | 2020 |
| Sayma Ltd | Hospitality | 2024 |
| SB Holdings (Exeter) Limited | Real estate | 2004 |
| SB Minor Works Limited | Construction | 2020 |
| SB Properties & Design Limited | Construction | 2017 |
| SBC Travel Limited | Wholesale & retail | 2024 |
| Sbmb Legal Ltd | Administrative & support | 2024 |
| Sbpm Partners UK Ltd | Professional & scientific | 2026 |
| SC Dermatology Limited | Health & social care | 2025 |
| SC Nature Recovery Ltd | Construction | 2024 |
| Scaff GUN & Accessories Ltd | Construction | 2025 |
| Scaffold Vehicle Rentals Ltd | Administrative & support | 2025 |
| Scaffolding Plymouth Ltd | Construction | 2016 |
| Scala Digital Limited | Wholesale & retail | 2023 |
| Scandinavian Housing Group Ltd | Real estate | 2021 |
| Scanniclift Limited | Professional & scientific | 2024 |
| Scanstrut (Holdings) Limited | Professional & scientific | 2011 |
| Scanstrut Group Limited | Manufacturing | 2012 |
| Scanstrut Limited | Manufacturing | 1999 |
| Scardau Limited | Professional & scientific | 1981 |
| Scarlett Group Ltd | Administrative & support | 2024 |
| Scarves for Sustainability Limited | Wholesale & retail | 2016 |
| Scbt Dining Limited | Hospitality | 2024 |
| SCC (Holdings) Limited | Financial services | 2015 |
| SCC Homes Limited | Real estate | 2024 |
| Scentistry Ltd | Wholesale & retail | 2026 |
| SCH Property Investments Limited | Real estate | 2023 |
| Schedge Limited | Information & communication | 2025 |
| Schofield Investments (SW) Limited | Financial services | 2005 |
| School Lane (Exeter) Management Limited | Professional & scientific | 2004 |
| Schools Health Education Unit Limited | Administrative & support | 1997 |
| SCI Leisure Ltd | Hospitality | 2015 |
| Science Consulting Ltd | Professional & scientific | 2022 |
| Scimar Engineering Limited | Manufacturing | 1987 |
| Scitor Ltd | Administrative & support | 2023 |
| Scmc Holdings Limited | Financial services | 2021 |
| Scoble & Park Limited | Manufacturing | 2024 |
| Scomis Limited | Extraterritorial | 2013 |
| Scorpio Technology Limited | Energy | 2020 |
| Scorpion Holdings and Investments Limited | Financial services | 2019 |
| Scot Developments Limited | Extraterritorial | 1996 |
| Scot Group Limited | Administrative & support | 1979 |
| Scot Group Southern Limited | Professional & scientific | 1999 |
| Scot Insurance Services Limited | Extraterritorial | 1996 |
| Scott & Tate Tree Surgeons Ltd | Agriculture & fishing | 2010 |
| Scott Franklin Ltd | Real estate | 2003 |
| Scott Security Solutions Ltd | Financial services | 2023 |
| Scott Shephard Management Ltd | Arts & recreation | 2025 |
| Scott T.A.G. Limited | Transport & logistics | 2005 |
| SCP Capital Limited | Real estate | 2020 |
| SCP Regent Street Limited | Construction | 2022 |
| SCP the Firs Ltd | Construction | 2022 |
| SCP Tiling & Stone Limited | Construction | 2011 |
| Scratchworks Theatre Community Interest Company | Education | 2023 |
| Screedmaster Group Limited | Real estate | 2025 |
| Screedmaster SW Limited | Construction | 2013 |
| Scrub a DUB Ltd | Other services | 2019 |
| Scrub a DUB Properties Ltd | Real estate | 2025 |
| Scuk Properties Ltd | Real estate | 2020 |
| SDB Management Limited | Real estate | 2009 |
| SDH Enterprise Limited | Hospitality | 2019 |
| SDR United Limited | Transport & logistics | 2011 |
| SDS Joinery and Mouldings Limited | Construction | 2020 |
| SE3 Design Ltd | Professional & scientific | 2018 |
| Sea Change International Ltd | Health & social care | 2026 |
| Sea Change Solutions Ltd | Professional & scientific | 2024 |
| Sea Kayak Torbay Limited | Administrative & support | 2025 |
| Sea Sanctuary Services Limited | Transport & logistics | 2018 |
| Sea-Trek Adventures Limited | Administrative & support | 2004 |
| Seabrook Clark Ltd | Financial services | 2012 |
| Seabrook Land Developments Limited | Real estate | 2017 |
| Seacat Investments Limited | Real estate | 2017 |
| Seafield Construction Ltd | Construction | 2026 |
| Seafield Development and Investment Ltd | Construction | 2017 |
| Seafield Group Ltd | Real estate | 2025 |
| Seafield Property (Exeter 1) Ltd | Real estate | 2026 |
| Search Builders Limited | Construction | 2019 |
| Search Well Homes Limited | Real estate | 2023 |
| SEARCH4LOCAL Limited | Professional & scientific | 2015 |
| Searchflow Limited | Information & communication | 2000 |
| Searchlight Business Services Limited | Information & communication | 2014 |
| Searock Developments Limited | Construction | 2010 |
| Seashell Communications Limited | Professional & scientific | 2012 |
| Seaside Swim School Ltd | Education | 2019 |
| Seasurfuk Limited | Wholesale & retail | 2023 |
| Seaton Heights Transformation Ltd | Real estate | 2007 |
| Seaton Jacques Construction Limited | Construction | 2026 |
| Seawood Yachts Limited | Transport & logistics | 2020 |
| Sebale Construction Limited | Construction | 2018 |
| Sebale Homes Ltd | Construction | 2021 |