| E D P Environmental Ltd | Professional & scientific | 2012 |
| E F Elite Coaching Ltd | Arts & recreation | 2022 |
| E J Mcguirl Limited | Manufacturing | 2014 |
| E&E Evergreen Properties Ltd | Real estate | 2026 |
| E&E Sweeps Limited | Construction | 2023 |
| E&O Home Ltd | Hospitality | 2018 |
| E&P Pattison Ltd | Real estate | 2018 |
| E-Department Limited | Wholesale & retail | 2011 |
| E-Influence Limited | Information & communication | 2024 |
| E-Space Project | Arts & recreation | 2011 |
| E-Werk Ltd | Manufacturing | 2022 |
| E.G. (Falmouth) Ltd | Hospitality | 2023 |
| E.I.C. Group Limited | Administrative & support | 2003 |
| E.I.C. Property Holdings Limited | Financial services | 2022 |
| E.I.C.(Exeter)Limited | Real estate | 1943 |
| E.R.S. 35 Ltd | Administrative & support | 2025 |
| E.S Cleaning Services Exeter Ltd | Administrative & support | 2025 |
| E.S.C.O.P. | Professional & scientific | 1996 |
| E.S.L. SW Ltd | Transport & logistics | 2024 |
| E1 Developments Limited | Real estate | 1990 |
| E8 Services Ltd | Construction | 2022 |
| EAD Ecology Ltd | Professional & scientific | 2015 |
| EAD Ecology Trustees Limited | Professional & scientific | 2022 |
| EAG Tax Advisory Services Limited | Professional & scientific | 2022 |
| Eagle Developments Limited | Real estate | 2021 |
| Eagle Land Limited | Construction | 2007 |
| Eagle One Aquae Sulis Limited | Real estate | 2017 |
| Eagle One Country Shopping Limited | Real estate | 1998 |
| Eagle One Estates Limited | Real estate | 1983 |
| Eagle One Holdings Limited | Financial services | 2001 |
| Eagle One Homes Limited | Construction | 1985 |
| Eagle One Investment Holdings Limited | Financial services | 2001 |
| Eagle One Investments Limited | Real estate | 2021 |
| Eagle One Leisure Holdings Limited | Financial services | 2001 |
| Eagle One Limited | Construction | 1983 |
| Eagle One Mmiii Limited | Real estate | 2002 |
| Eagle One Mmvi Limited | Real estate | 2006 |
| Eagle One NDD Limited | Administrative & support | 2021 |
| Eagle One Residential Limited | Real estate | 2015 |
| Eagle One Retail Limited | Real estate | 1998 |
| Eagle One Securities Limited | Financial services | 1991 |
| Eagle Rock Limited | Real estate | 1998 |
| EAR, Knows & Throat Limited | Information & communication | 2016 |
| Earls Property Development Ltd | Real estate | 2024 |
| Earls Property Estates Limited | Real estate | 2025 |
| Early Bird Apps Ltd | Information & communication | 2020 |
| Earp Developments Ltd | Construction | 2020 |
| Earth Horizon Group Limited | Professional & scientific | 2024 |
| Earthouse CIC | Professional & scientific | 2023 |
| Earthwise Vegetation Management Ltd | Agriculture & fishing | 2026 |
| East Africa Journeys Ltd | Administrative & support | 2019 |
| East Bowley Holidays Ltd | Hospitality | 2022 |
| East Devon (Securities) Limited | Real estate | 2013 |
| East Devon Gardening Supplies Ltd | Professional & scientific | 2025 |
| East Devon Heaths Land Management Company Limited | Real estate | 2005 |
| East Devon News Media Ltd | Information & communication | 2020 |
| East Devon Pebblebed Heaths Conservation Trust | Real estate | 2005 |
| East Devon Roofing Ltd | Construction | 2018 |
| East Devon Surgical Limited | Health & social care | 2023 |
| East EXE Electrical Ltd | Construction | 2019 |
| East of EXE Limited | Real estate | 2010 |
| Eastern Flavour (Southwest) Limited | Hospitality | 2017 |
| Eastfield Energy Limited | Energy | 2024 |
| Eastgate Financial Services (Exeter) Limited | Financial services | 2005 |
| Eastgate Holdings (Exeter) Limited | Financial services | 2008 |
| Easton Estates and Properties Ltd | Real estate | 2023 |
| Eastwick Road Limited | Financial services | 2017 |
| Easy Car Tuning Ltd | Wholesale & retail | 2015 |
| Easy MOT Exeter Ltd | Wholesale & retail | 2023 |
| Easy Peasy Tutoring Ltd | Education | 2026 |
| Easy Scanner Ltd | Other services | 2019 |
| Easytreads Ltd | Manufacturing | 2026 |
| Eatnicebenice Ltd | Hospitality | 2015 |
| Eaton 2 Management Limited | Households | 2025 |
| Eaton Court Homes Ltd | Real estate | 2016 |
| Eatonbray Ltd | Professional & scientific | 2008 |
| Ebanisto Limited | Wholesale & retail | 2023 |
| EBB & Flow Home Limited | Wholesale & retail | 2016 |
| EBB and Flow Travel Limited | Hospitality | 2020 |
| Ebers Hotel (Nottingham) Ltd | Hospitality | 2016 |
| EBH Avocet Limited | Real estate | 2024 |
| ECA Consultancy (SW) Ltd | Professional & scientific | 2026 |
| ECC Residencies Limited | Real estate | 2020 |
| Ecgj Property & Investments Ltd | Real estate | 2026 |
| Echo BMS Ltd | Information & communication | 2023 |
| Echo Surf Ltd | Wholesale & retail | 2022 |
| Echo Verde Ltd | Professional & scientific | 2025 |
| Echoes Childcare Limited | Health & social care | 2013 |
| Eclaro Clinics Limited | Health & social care | 2026 |
| ECM (SW) Ltd | Hospitality | 2020 |
| Eco Architects Limited | Extraterritorial | 2008 |
| Eco Baby Box Ltd | Wholesale & retail | 2026 |
| Eco BEE Energy Ltd | Construction | 2023 |
| Eco Bricks Ltd | Manufacturing | 2019 |
| Eco Home Solutions SW Ltd | Construction | 2020 |
| Eco Marine Deck Ltd | Manufacturing | 2022 |
| Ecoblend Technologies Investment Company Ltd | Financial services | 2018 |
| Ecogo Solutions Ltd | Construction | 2022 |
| Ecologic Consultant Ecologists LLP | | 2010 |
| Ecological Energy Ltd | Energy | 2009 |