| DR Pepper's Care Corporation Limited | Health & social care | 1998 |
| DR SAM Willis Ltd | Education | 2017 |
| DR Sonia Dental & Aesthetics Limited | Health & social care | 2021 |
| DR Ukoha Medical Services Ltd | Health & social care | 2026 |
| DR Vicky Hill Ltd | Financial services | 2024 |
| DR. William Business Growth Acceleration Practice Ltd | Professional & scientific | 2018 |
| Dragon AI Ltd | Hospitality | 2023 |
| Dragon Slayers Gaming CIC | Health & social care | 2025 |
| Dragonfly Foods Limited | Manufacturing | 1991 |
| Dragonrose Holdings Limited | Financial services | 2019 |
| Drake Project Management Limited | Construction | 2017 |
| Drakemead Limited | Professional & scientific | 2005 |
| Drama Llama Competitions Limited | Arts & recreation | 2025 |
| Dramatic Improvement West Ltd | Education | 2013 |
| Drayford Productions Limited | Arts & recreation | 2007 |
| Dready Brand Ltd | Wholesale & retail | 2014 |
| Dream Construction Limited | Construction | 2019 |
| Dreamabstract Ltd | Information & communication | 2021 |
| Dreys Court Management Company Limited | Households | 1974 |
| Driftwood Close Management Company Limited | Households | 2022 |
| Drink ME Spirits Limited | Manufacturing | 2026 |
| Drive Creative Studio Limited | Information & communication | 2013 |
| Drive Perfect Ltd | Education | 2025 |
| Drive Recruiting Limited | Administrative & support | 2022 |
| Drivedream Logistics Ltd | Transport & logistics | 2024 |
| Driven to Improve Ltd | Wholesale & retail | 2024 |
| Drm-Nights Ltd | Hospitality | 2023 |
| Drogo (SW) Limited | Construction | 1983 |
| Dronedesk Ltd | Extraterritorial | 2019 |
| Droppzy Holdings Ltd | Extraterritorial | 2025 |
| Drum Construction Ltd | Construction | 2004 |
| Drumen Limited | Health & social care | 2016 |
| DRUMS4HEALTH Ltd | Arts & recreation | 2024 |
| Drury Smith Group Limited | Professional & scientific | 2022 |
| DS & Sons Properties Limited | Real estate | 2020 |
| DS Developments (Exeter) Ltd | Construction | 2015 |
| DS Groundworks Ltd | Construction | 2021 |
| Ds&Nb LLP | | 2024 |
| Dscm Properties Ltd | Real estate | 2020 |
| Dsfrs Cods C.I.C. | Arts & recreation | 2022 |
| DSG Motors (SW) Ltd | Wholesale & retail | 2026 |
| DSG Motors Ltd | Wholesale & retail | 2022 |
| DSJ Property Development Limited | Real estate | 2019 |
| Dsjil Limited | Professional & scientific | 2026 |
| DSM Holdings (SW) Limited | Financial services | 2024 |
| DSR Civils Ltd | Construction | 2022 |
| DT Logistics Consultancy Limited | Transport & logistics | 2013 |
| DT4 Management Consultancy Limited | Professional & scientific | 2026 |
| Dtwo Creative Ltd | Administrative & support | 2004 |
| DUB Plastics Limited | Wholesale & retail | 2012 |
| Dubwiser Limited | Information & communication | 2016 |
| Duck Bakery Limited | Manufacturing | 2022 |
| Duckrowe Limited | Professional & scientific | 2026 |
| Dudman Aggregates Limited | Mining & quarrying | 2011 |
| Dudman Haulage Limited | Transport & logistics | 2011 |
| Dudman Ready Mixed Concrete Limited | Manufacturing | 1998 |
| Dudman Shaw Limited | Professional & scientific | 2004 |
| Dudos Online Ltd | Information & communication | 2012 |
| Dulford Copse Limited | Agriculture & fishing | 2015 |
| Dunbia (UK) | Manufacturing | 1997 |
| Dunchideock Barton Limited | Agriculture & fishing | 2022 |
| Dunco Properties Ltd | Real estate | 2023 |
| Dunco Property Solutions Ltd | Real estate | 2026 |
| Dunhill Wood Ltd | Households | 2022 |
| Dunn & Baker LLP | | 2013 |
| Dunn Marino Associates Limited | Professional & scientific | 2005 |
| Dunnets Local Ltd | Wholesale & retail | 2022 |
| Dunns Staple Fitzpaine Limited | Financial services | 2015 |
| Dunonin Resources Ltd | Mining & quarrying | 2026 |
| Duplex Scanning Services Limited | Health & social care | 2012 |
| Duraform Group Limited | Financial services | 2025 |
| Duraform Homes Ltd | Construction | 2021 |
| Durbeyfield Park (Marnhull) Management Company Limited | Real estate | 2024 |
| Dusk Lighting Limited | Wholesale & retail | 2009 |
| Dust Bunnies Cleaning Services Ltd | Administrative & support | 2021 |
| DVI UK Limited | Information & communication | 2017 |
| DVL Trans Ltd | Transport & logistics | 2017 |
| DVM Development Solutions Ltd | Construction | 2017 |
| DVR Group Ltd. | Transport & logistics | 2023 |
| DW Management Ltd | Real estate | 2018 |
| DW Sales Southwest Limited | Wholesale & retail | 2025 |
| DWB Architectural Design Limited | Professional & scientific | 2024 |
| DWD Assets Ltd | Financial services | 2025 |
| DWD Renewables Ltd | Construction | 2020 |
| DWD Utilities Ltd | Construction | 2023 |
| Dwelling Stays Limited | Real estate | 2024 |
| Dwilliams Contractors Ltd | Professional & scientific | 2022 |
| Dwmh Limited | Water & waste | 2001 |
| Dwml Holdings Limited | Professional & scientific | 2015 |
| Dynamic Solutions SW Ltd | Construction | 2024 |
| Dynamic SW Cleaning Ltd | Administrative & support | 2025 |
| Dynamics Programme Services Ltd | Information & communication | 2017 |
| Dynamiq Labs Ltd | Professional & scientific | 2019 |
| Dyrbus Holdings Limited | Real estate | 2021 |
| DYS Space Limited | Other services | 2016 |
| Dzimba CS Investment Ltd | Real estate | 2024 |
| Dzimba Investment Ltd | Real estate | 2023 |
| D’Evans Maintenance Ltd | Manufacturing | 2026 |
| E a Grey Civil Engineering Solutions Limited | Construction | 2010 |
| E B Hospitality Limited | Hospitality | 2021 |