| Stbenetsrcg Ltd | Health & social care | 2019 |
| STC Educational Ltd | Administrative & support | 2018 |
| STC Expeditions Ltd | Administrative & support | 2018 |
| Stealth Business Consultancy Ltd | Administrative & support | 2023 |
| Steam Ales Limited | Manufacturing | 2019 |
| Steamy Kitchen Ltd | Hospitality | 2023 |
| Steeleworks Affiliates Ltd | Professional & scientific | 2025 |
| Steer Sports and Education Limited | Education | 2017 |
| Stella Training Limited | Education | 2019 |
| Stem Cell Education and Research | Education | 2022 |
| Step Forward Coaching Ltd | Education | 2026 |
| Step One Charity | Health & social care | 1945 |
| Step-Top Ltd | Households | 2021 |
| Stephanie Cole Ltd | Arts & recreation | 2025 |
| Stephen Harris Anaesthetic Group Limited | Health & social care | 2022 |
| Stephen Heathcote Property Surveying Limited | Professional & scientific | 2013 |
| Stephen Nunn Law Limited | Professional & scientific | 2017 |
| Stephens Repair Ltd | Other services | 2022 |
| Stephens Scown Employee Ownership Company Limited | Professional & scientific | 2015 |
| Stephens Scown LLP | | 2010 |
| Stephenson & Roche Geoconsulting Ltd | Professional & scientific | 2023 |
| Stepping Stone Trustees Limited | Financial services | 2025 |
| Sterling Vanguard Property Ltd | Real estate | 2025 |
| Sterok Ltd | Wholesale & retail | 2017 |
| Steve Brook Haulage Limited | Transport & logistics | 2012 |
| Steve Clarke Garages Limited | Wholesale & retail | 2006 |
| Steve Gray Risk Consultancy Ltd | Professional & scientific | 2017 |
| Steve Handy Building Services Limited | Construction | 2017 |
| Steve Kingdon Plant Hire Ltd | Administrative & support | 2021 |
| Steve Swift Forestry Contracting Ltd | Agriculture & fishing | 2014 |
| Steven Ainge Plumbing, Heating & Cooling Ltd | Construction | 2021 |
| Stevens Properties (Devon) Limited | Real estate | 2020 |
| Stevenson Cook Ltd | Administrative & support | 2026 |
| Stevenson Squared Ltd | Administrative & support | 2021 |
| Stevenson Storage Ltd | Transport & logistics | 2026 |
| Steward Woodland & Land Management Limited | Agriculture & fishing | 2015 |
| Stewart Medics Ltd | Health & social care | 2024 |
| Stewart Trading Ltd | Wholesale & retail | 2022 |
| Steyr Arms UK Limited | Extraterritorial | 2019 |
| Stile Farm Feeds Limited | Wholesale & retail | 2016 |
| Still Loading Games Ltd | Information & communication | 2026 |
| Still Materials Handling Limited | Wholesale & retail | 1979 |
| Stisan Investments Limited | Real estate | 1961 |
| Stitch 2 Print Ltd | Wholesale & retail | 2022 |
| STM (Gloucester) Ltd | Hospitality | 2025 |
| STN Data Ltd | Information & communication | 2025 |
| Stobi Ltd | Construction | 2016 |
| Stock EXE Ltd | Wholesale & retail | 2020 |
| Stock-Pile Limited | Financial services | 2026 |
| Stockmans (Devon) Limited | Hospitality | 2003 |
| Stockmans (South West) Limited | Hospitality | 2011 |
| Stocktonbridge Limited | Real estate | 2019 |
| Stoic Freehold Ltd | Real estate | 2025 |
| Stoic Leasehold Ltd | Real estate | 2025 |
| Stoke Canon Inn Limited | Hospitality | 2011 |
| Stoke Meadow (Calne) Management Company Limited | Real estate | 2018 |
| Stoke Vale Farms Limited | Agriculture & fishing | 2017 |
| Stoked Comps Limited | Wholesale & retail | 2024 |
| Stoked Embers Ltd | Construction | 2024 |
| Stone Petal Studio Ltd | Professional & scientific | 2025 |
| Stone Tree Dairy Ltd | Manufacturing | 2024 |
| Stonebarrow Energy Limited | Energy | 2023 |
| Stonebridge International Limited | Other services | 2022 |
| Stonehengeit Ltd | Information & communication | 2015 |
| Stoneman and Bowker Limited | Wholesale & retail | 1973 |
| Stonewall Limited | Real estate | 1993 |
| Stoneycroft Holdings Limited | Professional & scientific | 2005 |
| Stoodleys Farm Ltd | Agriculture & fishing | 2025 |
| Stopgap Stays Ltd | Real estate | 2022 |
| Stopncii Limited | Information & communication | 2026 |
| Storey Interiors Ltd | Professional & scientific | 2022 |
| Stormpress Ltd | Manufacturing | 2002 |
| Stormpress Trustees Limited | Administrative & support | 2021 |
| Storrow Properties Ltd | Real estate | 2021 |
| Stothert Consulting Engineers Ltd | Professional & scientific | 2017 |
| Stovax Gazco Ltd | Manufacturing | 1981 |
| Stovax Heating Group Limited | Professional & scientific | 2012 |
| Stovax Limited | Financial services | 2010 |
| Stovetec Limited | Manufacturing | 2015 |
| Stoyles Engineering Services Ltd | Professional & scientific | 2022 |
| STR Electrical Engineering Limited | Professional & scientific | 2025 |
| Strand Developments & Interiors Limited | Real estate | 2010 |
| Strand Fish Bar Exmouth Limited | Hospitality | 2024 |
| Strand Fishbar and Kebab House Ltd | Hospitality | 2019 |
| Strangaton Game Farm Limited | Agriculture & fishing | 2013 |
| Strata Service Solutions Ltd. | Information & communication | 2014 |
| Strategy Ventures Ltd | Financial services | 2025 |
| Stratford House (Exeter) Limited | Wholesale & retail | 2014 |
| Strawberry Invest Limited | Financial services | 2014 |
| Strax (U.K.) Limited | Information & communication | 1999 |
| Street Food Southwest Inc LLP | | 2018 |
| Street Kicks Limited | Arts & recreation | 2026 |
| Street Motion Ltd | Education | 2022 |
| Strete Ralegh House Management Company Limited | Real estate | 2003 |
| Strikeup Limited | Information & communication | 2026 |
| Strikolith UK Limited | Extraterritorial | 2005 |
| Stringer Environmental Science Limited | Professional & scientific | 2014 |
| Stripes Pizza Ltd | Hospitality | 2024 |
| Strong Self Coaching Ltd | Health & social care | 2026 |
| Structura Frames Limited | Construction | 2026 |