| Springfield Terrain Limited | Manufacturing | 2026 |
| Springhill Solar Park Limited | Energy | 2011 |
| Springlands Exminster Limited | Health & social care | 2012 |
| Springvale Homes Ltd | Real estate | 2018 |
| Springwater Wild Learning LLP | | 2025 |
| Sprintco Ltd | Transport & logistics | 2024 |
| Spurway Motors Limited | Wholesale & retail | 2022 |
| Square PEG Property Ltd | Real estate | 2025 |
| Squareball Developments Ltd | Real estate | 2015 |
| Squibb Freestyle Circus Limited | Arts & recreation | 2006 |
| Squibb Solo FMX Limited | Administrative & support | 2014 |
| Squires Consulting Limited | Professional & scientific | 2007 |
| Squires Electrical & Security Ltd | Construction | 2006 |
| Squires Property and Rental Ltd | Real estate | 2025 |
| Squirrel Accommodation Limited | Real estate | 2007 |
| SR Gems and Minerals Ltd | Wholesale & retail | 2022 |
| SR Properties Mangement & Investments Ltd | Real estate | 2026 |
| SR Tech Service Limited | Information & communication | 2026 |
| SRD Tax Management Limited | Professional & scientific | 2011 |
| SRJ Building Services Ltd | Construction | 2023 |
| SRK MRI Ltd | Health & social care | 2014 |
| SRL Couriers Limited | Transport & logistics | 2026 |
| SRM Hygiene & Catering Equipment Supplies Ltd | Wholesale & retail | 2001 |
| Srpo Limited | Professional & scientific | 2017 |
| SRW Worldwide Ltd | Construction | 2025 |
| SS Exet Ltd | Construction | 2024 |
| SSD Groundwork Ltd | Construction | 2023 |
| Ssia Limited | Professional & scientific | 2016 |
| SSR Global Service Ltd | Hospitality | 2026 |
| Ssrh Ltd | Wholesale & retail | 2003 |
| ST Aubyn's Rise Property Management Company Limited | Real estate | 2014 |
| ST Christopher's C of E (Primary) Multi Academy Trust | Education | 2013 |
| ST Columb Solar Park Limited | Energy | 2012 |
| ST David's Hill (Exeter) Property Management Company Limited | Households | 1993 |
| ST James Consultancy Limited | Professional & scientific | 2003 |
| ST James Equity Limited | Financial services | 2011 |
| ST Joseph Investments Ltd | Real estate | 2025 |
| ST Leonards Medical Ltd | Health & social care | 2018 |
| ST Leonards News Limited | Wholesale & retail | 2011 |
| ST Luke's View Management Limited | Administrative & support | 2009 |
| ST Margaret's Residences (Exeter) Limited | Real estate | 2013 |
| ST Margaret's Residences Management Company Limited | Households | 2019 |
| ST Peters Mount Limited | Real estate | 2024 |
| ST Pier Partnership Ltd | Wholesale & retail | 2020 |
| ST Reylinsburg Limited | Education | 2020 |
| ST Sidwell's Centre Exeter | Hospitality | 2007 |
| ST Sidwell's Trading Company Limited | Manufacturing | 2018 |
| ST Thomas Markets CIC | Administrative & support | 2024 |
| ST Wilfred's Court Exeter Management Company Limited | Real estate | 1996 |
| ST. Breward Stores Limited | Wholesale & retail | 2017 |
| ST. Bridget Nurseries Limited | Agriculture & fishing | 1976 |
| ST. Hilarian (Exmouth) Management Company Limited | Households | 2001 |
| ST. Ives Corporation Limited | Real estate | 1996 |
| ST. James's Lodge Healthcare Ltd | Health & social care | 2008 |
| ST. Leonard's Dental Practice Limited | Health & social care | 2009 |
| Stacey's HGV Transport Recruitment Ltd | Administrative & support | 2023 |
| Staceys HGV Recruitment Ltd | Administrative & support | 2025 |
| Stachera Transport Ltd | Transport & logistics | 2025 |
| Stage Engage Limited | Other services | 2014 |
| Stage Engineering Limited | Manufacturing | 2009 |
| Stage House SW19 Limited | Households | 2023 |
| Stalite Signs (Holdings) Limited | Financial services | 2011 |
| Stalite Signs Limited | Manufacturing | 1957 |
| Stallcombe Eco Power Ltd | Energy | 2015 |
| Stamford House Dental Practice Ltd | Health & social care | 2019 |
| Stamp James LLP | | 2018 |
| Stan's Auto Repairs Limited | Wholesale & retail | 2024 |
| Stanbridge Road Developments Limited | Real estate | 2000 |
| Staplegrove Anaesthetists LLP | | 2007 |
| Stapleton & Hext Properties Ltd | Real estate | 2024 |
| Star 23 Ltd | Hospitality | 2023 |
| Star Book Sales LLP | | 2019 |
| Star Exeter Holdings Ltd | Financial services | 2019 |
| Star Exeter Limited | Education | 2017 |
| Star Holiday Lets Limited | Real estate | 2021 |
| Star Property Lets Limited | Real estate | 2022 |
| Star Stays Limited | Hospitality | 2021 |
| Starcross Yacht Club Company Limited | Arts & recreation | 1958 |
| Stardelta Audio Mastering Ltd | Information & communication | 2014 |
| Stardm Ltd | Information & communication | 2007 |
| Starflower Consulting Limited | Professional & scientific | 2020 |
| Starlight Enabling Ltd | Administrative & support | 2021 |
| Starlight Properties Ltd | Real estate | 2025 |
| Starling Property Solutions Ltd | Real estate | 2024 |
| Starlings Properties Limited | Real estate | 2025 |
| Starlingsuk Limited | Hospitality | 2022 |
| Start Bay Productions Limited | Other services | 2025 |
| Startassign Property Management Limited | Households | 1991 |
| Startup Trading Limited | Information & communication | 2016 |
| Starzyk Ltd | Transport & logistics | 2020 |
| Statera Financials Ltd | Professional & scientific | 2026 |
| Static Homes UK Ltd | Transport & logistics | 2019 |
| Station Yard Holdings Limited | Water & waste | 2012 |
| Staxy Ltd | Transport & logistics | 2020 |
| Stay Spaces Group Ltd | Hospitality | 2022 |
| Stayaurora Ltd | Real estate | 2019 |
| Stayrise Limited | Agriculture & fishing | 1990 |
| STAYS4U Ltd | Real estate | 2024 |
| Staystay Ltd | Real estate | 2019 |
| STB (SW) Ltd | Wholesale & retail | 2019 |