| Southwest G.R.P Services Ltd | Manufacturing | 2019 |
| Southwest Ground Rents Ltd | Real estate | 2020 |
| Southwest Paintball Limited | Arts & recreation | 2001 |
| Southwest Pharma Limited | Wholesale & retail | 2022 |
| Southwest Plastering & Rendering Services Ltd | Construction | 2023 |
| Southwest Property & Trading Limited | Real estate | 2015 |
| Southwest Risk Solutions Ltd | Construction | 2025 |
| Southwest Sandwich Company Ltd | Wholesale & retail | 1994 |
| Southwest Spine Ltd | Health & social care | 2014 |
| Southwest Sports Agency Limited | Arts & recreation | 2017 |
| Southwest UK Properties Ltd | Real estate | 2023 |
| Souzacomputers Ltd | Information & communication | 2020 |
| Sovereign Properties (Somerset) Limited | Real estate | 1976 |
| Sovereign Weddings and Events Ltd | Hospitality | 2014 |
| Sovwood Bidco Limited | Financial services | 2025 |
| Sovwood Midco Limited | Financial services | 2025 |
| Sowton Car and Van Repairs Limited | Wholesale & retail | 2013 |
| Sowton Mills Limited | Wholesale & retail | 1996 |
| Sowton Motor Co. Limited | Extraterritorial | 1999 |
| Sowton Mots Ltd | Wholesale & retail | 2013 |
| Sowton Storage Limited | Other services | 2025 |
| Sowton Tyres and Mots Ltd | Wholesale & retail | 2019 |
| SP Auto Repair & Diagnostics Ltd | Wholesale & retail | 2020 |
| SP Cleaning (SW) Ltd | Administrative & support | 2025 |
| SP Motorcycles Limited | Wholesale & retail | 2007 |
| SP Properties (Oxford) Limited | Real estate | 2020 |
| SP Properties (SW) Limited | Real estate | 2021 |
| Spa Town Property Ltd | Real estate | 2020 |
| Space Clipper Industries Limited | Professional & scientific | 2022 |
| Space Creatives Limited | Professional & scientific | 2005 |
| Space Hair & Beauty Ltd | Other services | 2015 |
| Space Place Management Company Limited | Real estate | 1988 |
| Space Roofs Limited | Wholesale & retail | 2017 |
| Space Vans Ltd | Financial services | 2023 |
| SPACE2THINK Ltd | Professional & scientific | 2007 |
| SPACE44 (Leisure) Limited | Hospitality | 2025 |
| SPACE44 Construction Ltd | Construction | 2016 |
| SPACE44 Ltd | Real estate | 2010 |
| Spaice Limited | Wholesale & retail | 2017 |
| Spark Cleaning Services Ltd | Wholesale & retail | 2025 |
| Spark Technology Services Limited | Health & social care | 1993 |
| Sparkle Cleaning (SW) Ltd | Administrative & support | 2026 |
| Sparkle Diva Limited | Other services | 2024 |
| Sparks Consultancy Services Limited | Administrative & support | 2013 |
| Sparrows ROW Management Limited | Real estate | 2015 |
| Spartan Piling RIG Sales Ltd | Construction | 2021 |
| Sparx Communications Limited | Administrative & support | 1998 |
| Sparx Limited | Education | 2012 |
| SPD Group SW Limited | Manufacturing | 2010 |
| SPD Property Inventories Ltd | Real estate | 2026 |
| Spec-Com-Tm Ltd | Manufacturing | 2026 |
| Specdeck Limited | Construction | 2021 |
| Specialist Cars (South West) Limited | Wholesale & retail | 1983 |
| Specialist Overhaul and Repair Aviation Ltd | Manufacturing | 2019 |
| Spectrum Film Productions Ltd | Information & communication | 2026 |
| Spectrum Kitchen Makeover Ltd | Professional & scientific | 2025 |
| Spectrum Services (South West) Ltd | Financial services | 2001 |
| Speed Superbikes Limited | Wholesale & retail | 2009 |
| Speek (UK) Ltd | Information & communication | 2019 |
| Speek Web Design & Marketing Limited | Information & communication | 2018 |
| Speltech Limited | Manufacturing | 2001 |
| Spencer Cobby Photography Limited | Professional & scientific | 2022 |
| Spencer Pratt Electrical Ltd | Manufacturing | 2012 |
| Spey Home Ltd | Wholesale & retail | 2026 |
| Spey Living Ltd | Wholesale & retail | 2025 |
| Speyfly Ltd | Manufacturing | 2025 |
| SPF Accountancy Ltd | Professional & scientific | 2013 |
| SPH Services South Ltd | Construction | 2017 |
| Sphere Commercials Ltd | Hospitality | 2023 |
| Sphere Product Design Ltd | Professional & scientific | 2018 |
| Spice Aroma Exeter Limited | Hospitality | 2023 |
| Spice Bazaar Ltd | Hospitality | 2026 |
| Spice Box Exeter Limited | Hospitality | 2025 |
| Spice Magic Devon Ltd | Hospitality | 2024 |
| Spicer Road Dental Practice Limited | Health & social care | 2011 |
| Spicery Works Ltd | Administrative & support | 2025 |
| Spinning Path Ltd | Information & communication | 2020 |
| Spiraluv Systems Ltd | Information & communication | 2015 |
| Spirits of YEO Ltd | Manufacturing | 2023 |
| Spiritstone Limited | Real estate | 2004 |
| Spiritual Journeys Limited | Administrative & support | 2011 |
| Spit and Sawdust Limited | Hospitality | 2013 |
| Spitfire Europe Ltd | Real estate | 2020 |
| Splicenet Limited | Information & communication | 2021 |
| Split Peas Ltd | Health & social care | 2024 |
| Spokes Consultants Ltd | Professional & scientific | 2024 |
| Sporting View Limited | Professional & scientific | 2009 |
| Sporty Stars Activity Group Limited | Arts & recreation | 2019 |
| Sporty Stars Franchise Limited | Arts & recreation | 2022 |
| Spoton.Net Limited | Information & communication | 2007 |
| Spqr Communications Ltd | Professional & scientific | 2011 |
| Spragg Training and Consultancy Limited | Health & social care | 2014 |
| Sprague & Ouseley Limited | Construction | 1961 |
| Sprayco Ltd | Other services | 2018 |
| Sprayex Bodyshop Ltd | Wholesale & retail | 2025 |
| Spring Consulting Ltd | Information & communication | 2026 |
| Spring Development Consultants Limited | Professional & scientific | 2012 |
| Springfield IT Management Limited | Extraterritorial | 2022 |
| Springfield Park Limited | Real estate | 1991 |
| Springfield Rental Management Limited | Extraterritorial | 2022 |