| Elluna Holdings Limited | Financial services | 2025 |
| ELM Andrews Limited | Construction | 2024 |
| ELM Construction & Property Maintenance Limited | Construction | 2016 |
| ELM Court (Polegate) Limited | Households | 2023 |
| ELM Health Ltd | Health & social care | 2026 |
| ELM House Dental Surgery Limited | Administrative & support | 2017 |
| ELM Pharma Ltd | Health & social care | 2018 |
| Elmbrae Court (Eastbourne) Limited | Extraterritorial | 2015 |
| Elmes and Smart Limited | Construction | 2012 |
| Eltham Dental Practice Limited | Health & social care | 2023 |
| Eltino Properties Limited | Households | 1997 |
| Eluminate Educational Services Ltd | Education | 2024 |
| Elysian Strategies Ltd | Information & communication | 2024 |
| Embrace the Change Ltd | Health & social care | 2026 |
| EMC Earley Management Consulting Ltd | Information & communication | 2019 |
| EMC Group Holdings Limited | Wholesale & retail | 2006 |
| EMC Property (Eastbourne) Limited | Wholesale & retail | 2016 |
| Emerald Construction (London) Limited | Construction | 2000 |
| Emerald Investments Holdings Limited | Extraterritorial | 2008 |
| Emerald Investments Ltd | Financial services | 2012 |
| Emerge Secure Limited | Manufacturing | 2016 |
| Emily Erlam Landscapes Limited | Administrative & support | 2011 |
| Emily Saint-Ablett Limited | Information & communication | 2024 |
| Emir Barber Ltd | Other services | 2020 |
| Emma Victoria Ltd | Other services | 2003 |
| Emmanuel Mennonite Church CIC | Other services | 2017 |
| Emma’S Helping Hands Services Ltd | Health & social care | 2018 |
| Emmi AI Limited | Information & communication | 2024 |
| EMO Consulting Ltd | Administrative & support | 2016 |
| Empire Garage Doors Limited | Extraterritorial | 2006 |
| Empire Group Holdings Ltd | Financial services | 2025 |
| Empire Studios Energy Ltd | Wholesale & retail | 2026 |
| Empyrean Outsourcing Limited | Professional & scientific | 2009 |
| EMS Limited | Manufacturing | 1997 |
| Emslie & Tarrant Limited | Real estate | 2002 |
| Emvi Barbers Ltd | Other services | 2024 |
| EMZ PT Ltd | Arts & recreation | 2021 |
| Enable & Support Ltd | Health & social care | 2023 |
| Enbright Limited | Professional & scientific | 2023 |
| Endeavour Business IT Solutions Limited | Information & communication | 2015 |
| Energy Impact Alliance Ltd | Professional & scientific | 2014 |
| Energy Incentives (Southern) Limited | Other services | 2011 |
| Energy Saving Double Glazing Ltd | Construction | 2013 |
| Enford Control Systems Ltd | Administrative & support | 2005 |
| Engine Rebuilders UK Ltd | Wholesale & retail | 2024 |
| Engines Kartel Ltd | Wholesale & retail | 2022 |
| Enginuity Edge Ltd | Professional & scientific | 2025 |
| English for Life Limited | Other services | 2010 |
| Ennea Horizon Studio Limited | Other services | 2025 |
| Enterprise Consulting South East Ltd | Professional & scientific | 2021 |
| Enterprise Group Ltd | Real estate | 2020 |
| Enterprise Homes Ltd | Real estate | 2020 |
| Envy Extensions Academy Ltd | Other services | 2024 |
| Enys Property Co.Limited | Households | 1959 |
| Eol-Group UK Limited | Manufacturing | 1996 |
| EP Contractors Limited | Administrative & support | 2009 |
| EPC Performance Ltd | Administrative & support | 2025 |
| Epica Designs Limited | Information & communication | 2022 |
| Epione Care Limited | Health & social care | 2025 |
| Epiphanic Medical Solution Limited | Health & social care | 2017 |
| Eqrbs Limited | Manufacturing | 2017 |
| Equator Principles Ltd. | Other services | 2023 |
| ERA International Trans Ltd | Hospitality | 2023 |
| Erasmus Technology Services Limited | Information & communication | 2024 |
| Erotikk Ltd | Manufacturing | 2020 |
| Erridge Plumbing and Heating Ltd | Professional & scientific | 2017 |
| ESH SUB Ltd | Hospitality | 2023 |
| Esher House Residents (Freehold) Limited | Households | 2024 |
| Esher House Residents Limited | Real estate | 2015 |
| Eshr Services Limited | Professional & scientific | 2023 |
| Eskay Estates Ltd | Real estate | 2017 |
| ESP Hvac Limited | Construction | 2019 |
| Esquire Property Management Services Limited | Hospitality | 2017 |
| Essential Beauty Salon & Spa Limited | Other services | 2014 |
| Essex Aesthetics Limited | Health & social care | 2011 |
| Essiby Ltd | Wholesale & retail | 2025 |
| Estate of Anwar Jalal Shemza Ltd | Arts & recreation | 2024 |
| Estatewise Limited | Real estate | 1988 |
| Estatewise Properties Limited | Real estate | 2021 |
| Estercomp Limited | Health & social care | 2017 |
| Estre Hair Ltd | Manufacturing | 2023 |
| ETC Holdings Eastbourne Limited | Real estate | 2021 |
| Ethertons Building Contractors Limited | Construction | 2021 |
| Ethic Patisserie Ltd | Hospitality | 2019 |
| Ethical Acquisitions Holdings Ltd | Financial services | 2020 |
| Ethical Care Prevention and Management of Violence and Aggression Ltd | Administrative & support | 2021 |
| Ethical Financial Planning Ltd | Financial services | 2007 |
| Ethical Fitness Ltd | Arts & recreation | 2018 |
| Ethicaled Consultancy Limited | Professional & scientific | 2010 |
| Ethik Software Limited | Information & communication | 2025 |
| Etny Ltd | Financial services | 2015 |
| ETS Waste Management Ltd | Water & waste | 2017 |
| EU Traders Ltd | Wholesale & retail | 2026 |
| Eugene Trading Ltd | Professional & scientific | 2021 |
| Euniqboutique Ltd | Wholesale & retail | 2026 |
| Euro Market BN21 Ltd | Wholesale & retail | 2025 |
| Euro Plant Installations Ltd | Construction | 2015 |
| Euro Recruitment Solutions Ltd | Extraterritorial | 2025 |
| Eurokits Ltd | Other services | 2016 |
| European Corporation Limited | Wholesale & retail | 1993 |