| Eastpond Properties Limited | Other services | 2021 |
| Eastwood House (Eastbourne) Limited | Households | 2004 |
| Easy Ceiling Technologies Ltd | Manufacturing | 2014 |
| Easy Live Auction Ltd | Information & communication | 2012 |
| Easymatics Limited | Information & communication | 2001 |
| EB Sporting Village Limited | Arts & recreation | 2023 |
| EB Ticket Resale Ltd | Wholesale & retail | 2022 |
| Ebca Ltd | Wholesale & retail | 2017 |
| Ebecpc Limited | Information & communication | 2004 |
| EBR Mortgages Limited | Financial services | 2023 |
| Eclectic Witch Collection Ltd | Wholesale & retail | 2021 |
| Eco Auditor Controls Specialists Limited | Construction | 2008 |
| Eco Golf Limited | Extraterritorial | 2021 |
| Eco Lifts Limited | Manufacturing | 2020 |
| Ecocar Partners Ltd | Wholesale & retail | 2026 |
| Ecohaven Limited | Wholesale & retail | 2020 |
| Ecommerce SV Limited | Wholesale & retail | 2025 |
| Economea Ltd | Administrative & support | 2020 |
| Ecoscreed Trading Limited | Construction | 1982 |
| Eddie Ward Art Ltd | Arts & recreation | 2023 |
| Eden Blue Centre Ltd | Health & social care | 2018 |
| Eden Firestopping Ltd | Public administration | 2025 |
| Edenberry Vineyard Ltd | Agriculture & fishing | 2017 |
| Edenthorpe Lodge Limited | Households | 1998 |
| Edge Ceramics Tiling Services Ltd | Wholesale & retail | 2023 |
| Edge Hill RTM Company Limited | Households | 2016 |
| EDH Bracken Ltd | Financial services | 2018 |
| Ediltechnologies Limited | Construction | 2023 |
| EDK Investments Limited | Real estate | 2018 |
| Edleston Build Limited | Construction | 2003 |
| EDR Consulting Limited | Administrative & support | 2022 |
| EDU & JOE Limited | Administrative & support | 2021 |
| EDUC8US Ltd | Education | 2015 |
| Educatio Limited | Education | 2014 |
| Education in London Ltd | Education | 2020 |
| Edusphere Consultancy Ltd | Professional & scientific | 2025 |
| EDV 2019 Limited | Extraterritorial | 1997 |
| Edward Alexander Group Holdings Limited | Wholesale & retail | 1991 |
| Edwards Building & Design Ltd | Construction | 2024 |
| Edwards Motor Works Ltd | Wholesale & retail | 2019 |
| Edwards Property Sussex Ltd | Real estate | 2024 |
| Eestairs UK Ltd | Professional & scientific | 2010 |
| Eeveespackpulls Ltd | Wholesale & retail | 2026 |
| Effective Innovations Limited | Manufacturing | 1991 |
| Effective Learning Environments Limited | Information & communication | 1999 |
| Egan House Limited | Households | 2024 |
| Egan House Management Company Ltd | Households | 2026 |
| EGE Healthcare Ltd | Health & social care | 2024 |
| EGG Free Cake Box Worthing Limited | Wholesale & retail | 2024 |
| Eggfree Cake Box Barking Limited | Wholesale & retail | 2016 |
| Eggfree Cake Box Grays Limited | Wholesale & retail | 2021 |
| Egls Consulting Ltd | Professional & scientific | 2016 |
| EHP Property Limited | Health & social care | 2002 |
| Eighteen Ninety Two Limited | Wholesale & retail | 2026 |
| EJ Robinson Physiotherapy Limited | Health & social care | 2014 |
| EJH Enterprises Ltd | Construction | 2025 |
| EKA Installation Ltd | Construction | 2017 |
| Ekbg Limited | Wholesale & retail | 2016 |
| EL Changarro Loncheria Ltd | Hospitality | 2026 |
| EL Parador Ltd | Professional & scientific | 2003 |
| Elaia Skincare Limited | Manufacturing | 2025 |
| Elan Beaute Ltd | Other services | 2023 |
| Elaniti Ltd. | Agriculture & fishing | 2022 |
| Elecsmith Electrical Limited | Construction | 2018 |
| Electric Cinemas Limited | Information & communication | 2021 |
| Electrical and Acoustic Services Limited | Information & communication | 1980 |
| Electricworkshop Ltd | Construction | 2022 |
| Electron Energy Limited | Construction | 2016 |
| Electron Installations Limited | Construction | 2006 |
| Eleise Ltd | Information & communication | 2018 |
| Elements Kapa Limited | Manufacturing | 2017 |
| Elenqi by Sreelekshmi Ltd | Manufacturing | 2026 |
| Elevate Your Look Limited | Wholesale & retail | 2018 |
| Elevate: Mind. Body. Soul. Ltd | Wholesale & retail | 2023 |
| Eleven Eleven Athletic Limited | Extraterritorial | 2024 |
| Elfland UK Limited | Manufacturing | 2021 |
| Elgin Park Dental Practice Limited | Health & social care | 2012 |
| Elgin Southern LLP | | 2012 |
| Elijah House Global Ltd | Other services | 2020 |
| Eliogarty MAY Ltd | Professional & scientific | 2018 |
| Eliora Property Limited | Households | 2024 |
| Elite Aesthetics Distribution Ltd | Wholesale & retail | 2024 |
| Elite Care Pulse Ltd | Administrative & support | 2024 |
| Elite Discos Limited | Arts & recreation | 2006 |
| Elite ENT Services Ltd | Health & social care | 2025 |
| Elite Health Holdings Ltd | Real estate | 2025 |
| Elite LUX Reformer Pilates Eastbourne Limited | Arts & recreation | 2025 |
| Elite LUX Studios Limited | Arts & recreation | 2025 |
| Elite Management Holdings Limited | Financial services | 2023 |
| Elite Performance Advisory Services Limited | Health & social care | 2021 |
| Elite Pilot Academy (South East) Ltd | Extraterritorial | 2023 |
| Elite Residency Ltd | Hospitality | 2024 |
| Elite Sales & Linguistics Limited | Real estate | 2010 |
| Elite Tree Surgery Limited | Agriculture & fishing | 2025 |
| ELJ Chiropractic Limited | Health & social care | 2022 |
| ELL Sea Property Ltd | Real estate | 2025 |
| Ellaerin Property Investments Limited | Real estate | 2022 |
| Elliot Office Supplies Limited | Wholesale & retail | 2003 |
| Elliott HR Limited | Administrative & support | 2024 |
| Ellis Lost Ltd | Information & communication | 2023 |