| Q Group (North East) Limited | Financial services | 2018 |
| QL Nails Ltd | Other services | 2026 |
| QLV Ltd | Wholesale & retail | 2023 |
| Qoxia Limited | Financial services | 2024 |
| Quality Style Online Ltd | Wholesale & retail | 2024 |
| Quality Tech and Lifestyle Ltd | Wholesale & retail | 2024 |
| Quantakasa Geoanalytics Ltd | Professional & scientific | 2025 |
| Quantx Limited | Information & communication | 2023 |
| Quarrington Biogas Ltd | Energy | 2021 |
| Quarrington Convenience Store Ltd | Wholesale & retail | 2020 |
| Quarrington Farms Ltd | Agriculture & fishing | 2014 |
| Quayside CBT Ltd | Health & social care | 2008 |
| Quetlaw Properties Limited | Households | 1997 |
| Quorum Fleet Solutions Ltd | Financial services | 2013 |
| Quotient Developments Limited | Real estate | 2023 |
| QVS Automotive Limited | Administrative & support | 2015 |
| R & B Properties North East Ltd | Real estate | 2025 |
| R & C Builders Limited | Construction | 2003 |
| R & K Developments (Durham) Ltd | Real estate | 2019 |
| R & P.J. Limited | Hospitality | 2004 |
| R & R Desai Limited | Real estate | 2017 |
| R a B Electrical Domestic & Commercial Ltd | Construction | 2022 |
| R Baker Ltd | Professional & scientific | 2024 |
| R D Utilities Limited | Energy | 2005 |
| R FOX Construction Ltd | Construction | 2025 |
| R Harold Cars & Commercials Limited | Wholesale & retail | 2011 |
| R Harold Properties Limited | Real estate | 2019 |
| R I Geotechnics Ltd | Professional & scientific | 2019 |
| R J H Gregory ( Surgical Services) Limited | Health & social care | 2013 |
| R J Naisbitt Ltd | Professional & scientific | 2006 |
| R Lyons Limited | Health & social care | 2024 |
| R R Building Services Limited | Administrative & support | 2024 |
| R T Community Projects Ltd | Health & social care | 2009 |
| R Tempest Ltd | Wholesale & retail | 2024 |
| R&D Convenience Store (NE) Ltd | Wholesale & retail | 2023 |
| R&M Bonnington Limited | Health & social care | 2019 |
| R&O Distribution Ltd | Wholesale & retail | 2024 |
| R. Hanson & SON Limited | Extraterritorial | 1995 |
| R.C.S. (1996) Limited | Hospitality | 1987 |
| R.Fifty Ltd | Hospitality | 2021 |
| R.L PUB Company Limited | Hospitality | 2026 |
| R.M. Myers & Co Limited | Construction | 1997 |
| R.S. Plant Hire & Groundworks Ltd | Construction | 2007 |
| R.T Taverns Company Limited | Hospitality | 2026 |
| R2R Specialised Cleaning Limited | Administrative & support | 2022 |
| Raby Road Flats RTM Company Limited | Households | 2025 |
| Rachel Leonard EP Ltd | Education | 2026 |
| Racking Holdings Ltd | Financial services | 2021 |
| RAD Developments North East Ltd | Construction | 2015 |
| Radiance Aesthetics Clinic Limited | Health & social care | 2026 |
| Radu Sima Logistics Ltd | Transport & logistics | 2025 |
| Raeco Ltd | Financial services | 2023 |
| Rags to Riches Professional Cleaning Services Limited | Administrative & support | 2023 |
| Raiali Limited | Real estate | 2024 |
| Railtown Coffee Limited | Wholesale & retail | 2013 |
| Rainbow Nursery (Middlestone Moor) Limited | Education | 2002 |
| Rainton Construction Limited | Construction | 1992 |
| Raintonitalian Ltd | Hospitality | 2026 |
| RAJ Ghar Ltd | Financial services | 2023 |
| RAK Food Services Ltd | Hospitality | 2023 |
| Ralph Properties NE Ltd | Real estate | 2021 |
| Ramsden Williams Publications Limited | | 1965 |
| Ramside Estates Limited | Hospitality | 1963 |
| Ramside Holdings Limited | Hospitality | 2007 |
| Ramsley Finance Limited | Financial services | 1986 |
| Ramxer Limited | Wholesale & retail | 2025 |
| Ramzi Ltd. | Health & social care | 2017 |
| Rane Aesthetics Ltd | Health & social care | 2020 |
| Ranked and Filed Ltd | Information & communication | 2023 |
| Ranns Professional Services Limited | Professional & scientific | 2015 |
| Rapid AID Healthcare Ltd | Professional & scientific | 2021 |
| Rappro Ltd | Professional & scientific | 2016 |
| Rara Enterprise Ltd | Real estate | 2026 |
| Rare-Candy Collectibles Limited | Wholesale & retail | 2025 |
| Ratcliffe Haulage & Storage Ltd | Construction | 2001 |
| Ratsoft Limited | Information & communication | 2018 |
| Ravan Construction Limited | Construction | 2014 |
| Ravello Limited | Hospitality | 2016 |
| Ravensworth Property Developments LLP | | 2005 |
| Ravensworth Realty Limited | Real estate | 2022 |
| Raversys Ltd | Information & communication | 2025 |
| Rawtdoor Limited | Manufacturing | 2014 |
| Rawtdoor Retail Ltd | Wholesale & retail | 2021 |
| Rawther Healthcare Ltd | Health & social care | 2022 |
| RB Leisure Taverns Ltd | Hospitality | 2026 |
| RBB Distribution Ltd | Wholesale & retail | 2023 |
| RBG Brickworks Ltd | Construction | 2026 |
| Rblh Auto Service Limited | Wholesale & retail | 2026 |
| RC Wholesale Trader Ltd | Wholesale & retail | 2020 |
| Rcla Limited | Professional & scientific | 2020 |
| RDL Energy Ltd | Professional & scientific | 2002 |
| RDT Saddles Limited | Wholesale & retail | 2024 |
| RDU Ltd | Construction | 2021 |
| Reality Media Group Ltd | Information & communication | 2017 |
| Recruit Potential Ltd | Administrative & support | 2018 |
| Recruiting Potential Ltd | Administrative & support | 2024 |
| Red & Co Limited | Administrative & support | 2012 |
| Red Box Contracts Limited | Construction | 2014 |
| Red Fire Restaurant Ltd | Hospitality | 2019 |
| Red Leaf Accountancy Ltd | Professional & scientific | 2011 |