| Power Flush Heating and Plumbing Ltd | Other services | 2016 |
| Powerlite Fitzgerald Limited | Manufacturing | 2025 |
| Powis Newsagents Limited | Wholesale & retail | 1998 |
| PR Haswell Criminal Defence Representation Ltd | Professional & scientific | 2026 |
| Prakash Tech Ltd | Other services | 2025 |
| Prashanth Koundinya Limited | Wholesale & retail | 2024 |
| Praxis Counselling Ltd | Health & social care | 2024 |
| PRE Formed Limited | Agriculture & fishing | 2021 |
| Precision Darts Limited | Wholesale & retail | 2026 |
| Precision Exercise Ltd | Health & social care | 2020 |
| Precision Golf Grips Ltd | Wholesale & retail | 2025 |
| Premier Graphics and Signs Limited | Administrative & support | 2013 |
| Premier Lime & Stone Company Limited | Mining & quarrying | 1956 |
| Premier Medical Group Limited | Other services | 2016 |
| Premier Protection Services Limited | Administrative & support | 2008 |
| Premium Game Ltd | Wholesale & retail | 2021 |
| Premm Food Limited | Hospitality | 2018 |
| Prepaid Games Ltd | Wholesale & retail | 2019 |
| Prestige Exclusive Homes Limited | Construction | 2009 |
| Pretty Magpie Limited | Wholesale & retail | 2023 |
| Pretty Pretty Good Limited | Administrative & support | 2009 |
| Pride Community Network Limited | Information & communication | 2017 |
| Pride Leisure Ltd | Hospitality | 2024 |
| Pride World Media Ltd | Information & communication | 2017 |
| Primal K9 Ltd | Other services | 2021 |
| Primary Financial Management Ltd | Financial services | 2008 |
| Prime Landings International Company Limited | Real estate | 2019 |
| Principal Fire Safety Ltd | Financial services | 2018 |
| Pringles (Durham) Limited | Construction | 2000 |
| Priority Facilities Management Limited | Administrative & support | 2021 |
| Priory Safety Services Limited | Professional & scientific | 2003 |
| Prisca Accommodation Solutions Ltd | Hospitality | 2019 |
| Prisca Solutions Ltd | Health & social care | 2017 |
| Privateer Properties Ltd | Real estate | 2015 |
| Procare North Limited | Administrative & support | 2010 |
| Procare Total Cleaning Services Limited | Administrative & support | 2011 |
| Procspec Limited | Professional & scientific | 2024 |
| Prodev (NE) Limited | Construction | 2004 |
| Profcoe Limited | Professional & scientific | 2019 |
| Professional Network Technology Solutions Limited | Information & communication | 2015 |
| Profit Mind AI Ltd | Information & communication | 2025 |
| Proformance Ltd | Construction | 2007 |
| Project 95 Ltd | Real estate | 2022 |
| Project Catix 1 Ltd | Professional & scientific | 2022 |
| Project Catix 2 Ltd | Professional & scientific | 2022 |
| Project Ilkxxx Ltd | Professional & scientific | 2023 |
| Project Itzg Ltd | Information & communication | 2025 |
| Project One (NE) Limited | Construction | 2016 |
| Project Services Maintenance 1 Limited | Construction | 2025 |
| Project Services National Carpets and Blinds Limited | Wholesale & retail | 2025 |
| Project Services National Ltd | Manufacturing | 2025 |
| Project Zebra Consultancy Ltd | Professional & scientific | 2021 |
| Project, Technical and Site Management Services Limited | Construction | 2014 |
| Project, Technical and Site Services LLP | | 2016 |
| Projekt Architects Limited | Professional & scientific | 2008 |
| Projekt Construction Limited | Professional & scientific | 2008 |
| Projekt Design and Management Limited | Construction | 2012 |
| Promarc Ltd | Information & communication | 2022 |
| Promeals Limited | Wholesale & retail | 2020 |
| Promodo Ltd | Professional & scientific | 2000 |
| Pronax Ltd | Professional & scientific | 2015 |
| Proofstand (Plastics) Limited | Construction | 2015 |
| Propel Business Associates Limited | Professional & scientific | 2008 |
| Propel Business LLP | | 2007 |
| Properly Group Ltd | Information & communication | 2025 |
| Property Partners (North East) Limited | Administrative & support | 2007 |
| Prospect Education Limited | Education | 2003 |
| Prospect House Properties (UK) Ltd. | Real estate | 2017 |
| Prosper Property Durham Limited | Real estate | 2024 |
| Protego Safety Limited | Professional & scientific | 2023 |
| Protostar Leadership Development Limited | Professional & scientific | 2007 |
| Proud Cleaning (NE) Limited | Administrative & support | 2012 |
| Provault Business Solutions & Technologies Ltd | Transport & logistics | 2025 |
| Providence Learning Partnership | Education | 2018 |
| Provisional Golf Ltd | Wholesale & retail | 2024 |
| Prsuk Capital Limited | Real estate | 2014 |
| Prwg Holdings Limited | Financial services | 2017 |
| Prydale Rooms Limited | Health & social care | 2022 |
| Przemag- Trans Ltd | Transport & logistics | 2016 |
| PSB52 Limited | Real estate | 2017 |
| PSP Finance Limited | Extraterritorial | 2021 |
| Psych Three Limited | Health & social care | 2026 |
| Psychological Services and Training Ltd | Education | 2021 |
| PUB Consultancy Services Limited | Information & communication | 2019 |
| Pubco Durham Ltd | Hospitality | 2020 |
| Pudo Hub Ltd | Transport & logistics | 2023 |
| Pukrik Homes Ltd | Construction | 2003 |
| Pulman Seat Limited | Wholesale & retail | 2010 |
| Pulman Skoda Limited | Wholesale & retail | 2010 |
| Pulse Delivery Solutions Ltd | Transport & logistics | 2026 |
| PULSEF1TNESS Ltd | Arts & recreation | 2026 |
| Punch Property Solutions Limited | Real estate | 2014 |
| Punktastic LLP | | 2011 |
| Purba Limited | Financial services | 2025 |
| Purba Nayyar Developments Ltd | Real estate | 2024 |
| Purdierose Limited | Real estate | 2018 |
| Purvis Construction Ltd | Construction | 2025 |
| PUSH2BECOME Care Ltd | Health & social care | 2023 |
| PWB Football Ltd | Professional & scientific | 2026 |
| Pwelsh Psychology Limited | Health & social care | 2024 |