| Schulz Professional Ltd | Professional & scientific | 2025 |
| Science, Technology and Research Specialists Ltd | Information & communication | 2013 |
| SCK Accountancy Ltd | Professional & scientific | 2006 |
| SCN Events Ltd | Administrative & support | 2025 |
| SCO Official Music Ltd | Arts & recreation | 2021 |
| Scobie Hamilton Ltd | Real estate | 2018 |
| Scocomp Limited | Professional & scientific | 2021 |
| Scoopaholic Ltd | Hospitality | 2025 |
| Scootamart (Dundee) Limited | Wholesale & retail | 2019 |
| Scope Consulting Limited | Extraterritorial | 2006 |
| Scorpio Estates Ltd | Households | 2018 |
| Scorus Group Limited | Construction | 2017 |
| Scot Ceylon Entertainment Limited | Hospitality | 2025 |
| Scot Foam Ltd | Construction | 2017 |
| Scot Homes Construction Ltd | Construction | 2020 |
| Scot Sweepers Ltd | Manufacturing | 2011 |
| Scotblue Ltd | Transport & logistics | 2008 |
| Scotblue Minibus Hire Ltd | Extraterritorial | 2016 |
| Scotburg Ventures L.P. | | 2015 |
| Scotcheer Ltd | Arts & recreation | 2022 |
| Scotfence Limited | Construction | 2024 |
| Scotfresh Group Ltd. | Other services | 1997 |
| Scotfresh Limited | Extraterritorial | 2014 |
| Scotgas Group Limited | Construction | 2019 |
| Scotia Dundee Limited | Hospitality | 2025 |
| Scotia Investment Properties Ltd | Real estate | 2018 |
| Scotia Plumbing and Heating Ltd | Construction | 2020 |
| Scotia Utility Consultants Ltd | Professional & scientific | 2016 |
| Scotjock Limited | Real estate | 2020 |
| Scotkerr Limited | Real estate | 2011 |
| Scotlaw Business Services Limited | Other services | 2003 |
| Scotmitch Scaffold Ltd | Construction | 2008 |
| Scotoneras CIC | Arts & recreation | 2024 |
| Scotra Ltd | Other services | 2024 |
| Scotrange UK Ltd | Manufacturing | 2004 |
| Scots Oak Properties Ltd. | Financial services | 1992 |
| Scots Oak Villas Ltd | Real estate | 2021 |
| Scotsafe Transport Ltd | Health & social care | 2025 |
| Scotsella Clinic Limited | Health & social care | 2020 |
| Scott and Scott 1619 Limited | Wholesale & retail | 2026 |
| Scott Brothers (Dundee) Limited | Manufacturing | 2012 |
| Scott Coyle Horse Sales & Training Limited | Agriculture & fishing | 2022 |
| Scott Fraser Hsse Services Ltd | Professional & scientific | 2012 |
| Scott Fyffe Wealth Management Ltd | Financial services | 2020 |
| Scott Import Export (Tayside) Limited | Information & communication | 1996 |
| Scott Property Maintenance Limited | Construction | 2014 |
| Scott Ross EX Ltd | Construction | 2013 |
| Scott Taylor-Contracts Ltd | Construction | 2016 |
| Scott Technical Services Ltd | Professional & scientific | 2013 |
| Scott Turnbull Plumbing and Heating Limited | Construction | 2021 |
| Scott Welding Services Limited | Administrative & support | 2009 |
| Scott's Brewing Company Limited | Manufacturing | 2025 |
| Scott's Kitchen (Dundee) Limited | Education | 2019 |
| Scott's Logistics Ltd | Transport & logistics | 2018 |
| Scottchina Huahai Education Limited | Public administration | 2017 |
| Scottdale Ltd | Other services | 2019 |
| Scottish Agritourism | Other services | 2021 |
| Scottish Centre for Excellence in Dentistry Ltd. | Health & social care | 2007 |
| Scottish Legal News Limited | Professional & scientific | 2008 |
| Scottwind Limited | Professional & scientific | 2025 |
| Scotvac Limited | Manufacturing | 2013 |
| Scrapantics CIC | Arts & recreation | 2015 |
| Screen Cuisine Scotland Limited | Hospitality | 2017 |
| Screenmedia Design Limited | Information & communication | 2004 |
| Scrimmy's Ltd | Hospitality | 2018 |
| Scrt Limited | Health & social care | 2008 |
| SCS Accounting Services Limited | Professional & scientific | 2020 |
| SCS Design Limited | Professional & scientific | 2016 |
| Scuderia Properties Limited | Real estate | 2015 |
| SDA Consultant Services Limited | Professional & scientific | 2016 |
| SDB Contracts Limited | Construction | 2014 |
| SDC Builders Perth Limited | Construction | 2026 |
| Sdfr Limited | Administrative & support | 2010 |
| SDG Clark Ltd | Construction | 2026 |
| Sdgd Properties Ltd | Other services | 2025 |
| Sdgrc Limited | Manufacturing | 2025 |
| SDM Construction and Project Management Limited | Construction | 2024 |
| Sdsm Properties Limited | Real estate | 1998 |
| SDT Property Limited | Real estate | 2022 |
| Sdwl Limited | Extraterritorial | 2024 |
| Sea (Ltd) Ltd | Professional & scientific | 2018 |
| Sea Braes Development Ltd | Construction | 2020 |
| Sea Socks Limited | Administrative & support | 2026 |
| Seaborn Shipping L.P. | | 2015 |
| Seabourne Properties Dundee Limited | Real estate | 2019 |
| Seabourne Services Limited | Manufacturing | 2024 |
| Seabraes Hospitality Limited | Hospitality | 2025 |
| Seabraes Limited | Professional & scientific | 2009 |
| Seafield Developments (Scotland) Ltd | Construction | 2022 |
| Seafield Estates Limited | Real estate | 2006 |
| Seafield Trading Limited | Professional & scientific | 2019 |
| Seagate (Dundee) Ltd | Real estate | 2015 |
| Seagate Foods Ltd | Hospitality | 2025 |
| Seagate Retail Ltd | Wholesale & retail | 2014 |
| Seagate Stores Limited | Wholesale & retail | 2026 |
| Seagate Trading Company Ltd | Hospitality | 2024 |
| Seahold Dundee Ltd | Financial services | 2025 |
| Sealine Organization L.P. | | 2015 |
| Sean Cabs Ltd | Transport & logistics | 2020 |
| Sean Reilly Property Investments Limited | Real estate | 2021 |