| Salon Fierce Limited | Other services | 2021 |
| Salon Fierce Training Academy Limited | Education | 2023 |
| Salstar Ltd | Professional & scientific | 2019 |
| Saltire Autos Ltd | Wholesale & retail | 2022 |
| Saltire Curaidh Limited | Hospitality | 2019 |
| Saltire Drilling Services Limited | Manufacturing | 2014 |
| Saltire Games Ltd | Manufacturing | 2025 |
| Saltire Machine Tools Ltd | Wholesale & retail | 2025 |
| Saltire Mountain Limited | Administrative & support | 2016 |
| Saltire Tides CIC | Education | 2025 |
| Saltire Will Solutions Limited | Financial services | 2025 |
| SAM & Sama Ltd | Hospitality | 2020 |
| SAM Cabs Ltd | Transport & logistics | 2020 |
| SAM Elassar Limited | Real estate | 2012 |
| SAM Grill Ltd | Hospitality | 2026 |
| SAM Skin Aesthetic & More Ltd | Other services | 2026 |
| SAM Strachan Ltd | Other services | 2018 |
| Sambi & Sambi Limited | Wholesale & retail | 2005 |
| Sameday ZIP Line Limited | Transport & logistics | 2017 |
| Sammed L.P. | | 2016 |
| Samnamic Properties Limited | Real estate | 1994 |
| Samo'R Cafe Limited | Hospitality | 2023 |
| Samuel Contracts (Edinburgh) Limited | Construction | 2011 |
| Samur Marketing LP | | 2017 |
| Samza Enterprise Ltd | Wholesale & retail | 2026 |
| SAN Rentals Ltd | Administrative & support | 2025 |
| Sanda Arts Ltd | Wholesale & retail | 2015 |
| Sandaig Engineering and Qa/Qc Consultancy Services Ltd | Professional & scientific | 2018 |
| Sandeman Properties Limited | Real estate | 2007 |
| Sandex Capital L.P. | | 2015 |
| Sandhu Definite Ltd | Hospitality | 2026 |
| Sandport Industries L.P. | | 2012 |
| Sandragold International Ltd | Financial services | 2025 |
| Sandton Hair Limited | Other services | 2014 |
| Sandy Mackie & SON Limited | Construction | 2025 |
| Sandy Smith (Butchers) Limited | Hospitality | 2003 |
| Sanfort Trading LP | | 2017 |
| Sangiovesa Ltd | Wholesale & retail | 2018 |
| Sangobeg Developments Limited | Real estate | 1995 |
| Sangobeg Investments Ltd. | Real estate | 1990 |
| Sangobeg Properties Ltd | Hospitality | 2018 |
| Sanjeev Limited | Hospitality | 2016 |
| Sansal Properties Ltd | Real estate | 2023 |
| Santus Logistics Ltd | Transport & logistics | 2018 |
| Sapling Homes Limited | Professional & scientific | 2006 |
| Sapphire Cabs Ltd | Transport & logistics | 2021 |
| Sapphire Clouds Ltd | Wholesale & retail | 2025 |
| Sapphire Properties Dundee Limited | Real estate | 2012 |
| Saputo Properties Ltd | Real estate | 2024 |
| Sarah Downs Consulting & Advisory Ltd | Professional & scientific | 2024 |
| Sarah Johnston Ltd | Professional & scientific | 2015 |
| Sarah W Ltd | Wholesale & retail | 2026 |
| Sarahk Pilates Ltd | Arts & recreation | 2025 |
| Saray Hot Food Ltd | Hospitality | 2018 |
| Sardar Group Ltd | Construction | 2018 |
| Sari Jehan Ltd | Information & communication | 2020 |
| Sark Property Solutions Ltd | Real estate | 2025 |
| Sarna Convenience Store Ltd | Wholesale & retail | 2019 |
| Sarpunch Limited | Hospitality | 2025 |
| Sarraf 4D Ltd | Health & social care | 2025 |
| Sarscomar Limited | Professional & scientific | 2020 |
| Sarwat Group Ltd | Professional & scientific | 2025 |
| Sarwat Ltd | Professional & scientific | 2025 |
| Sasha's Corner Ltd | Hospitality | 2025 |
| Satex Ventures L.P. | | 2015 |
| Saturn FE Limited | Professional & scientific | 2018 |
| Saturn Fluid Engineering Group Limited | Professional & scientific | 2024 |
| Saturn Fluid Engineering Limited | Professional & scientific | 2016 |
| Saturn Integrity Management Limited | Administrative & support | 2023 |
| Saturn Renewables Limited | Professional & scientific | 2021 |
| Saturn Subsea Limited | Professional & scientific | 2020 |
| Satyn Distribution LP | | 2015 |
| Savannah Marine Surveyors Limited | Professional & scientific | 2010 |
| Save Commercial Energy Ltd | Administrative & support | 2018 |
| Saverschoice UK Limited | Wholesale & retail | 2014 |
| Savii Education Services Ltd | Information & communication | 2021 |
| SAW Portfolio Ltd | Real estate | 2022 |
| Saywaa Ltd | Administrative & support | 2025 |
| Sayys Ltd | Transport & logistics | 2015 |
| SAZ Properties Group Limited | Households | 2026 |
| Saza Ltd | Real estate | 2019 |
| SB Cabs Ltd | Transport & logistics | 2022 |
| SB Global HR and Legal LLP | | 2019 |
| SB Joinery Projects Limited | Construction | 2026 |
| SBM Management Ltd | Construction | 2026 |
| SC Sewing Ltd | Other services | 2018 |
| SC Tayside Investments Limited | Real estate | 2009 |
| SC Welding Services Ltd | Construction | 2025 |
| SCA Engineering Ltd | Professional & scientific | 2023 |
| Scaffelders Ltd | Construction | 2025 |
| Scale to Zero Limited | Information & communication | 2017 |
| Scan Building Services Limited | Construction | 1980 |
| Scandilux L.P. | | 2015 |
| Scandinavian Interiors Limited | Wholesale & retail | 1998 |
| SCG Offshore Ltd | Construction | 2024 |
| SCH Boxing Limited | Arts & recreation | 2025 |
| Scheme Ltd | Construction | 2020 |
| Schemers Film Limited | Information & communication | 2016 |
| Schiehallion Limited | Real estate | 2010 |
| Schneider & SON Ltd | Construction | 2018 |