| Smith R J Limited | Wholesale & retail | 2016 |
| Smiths Electrical Services Ltd | Construction | 2024 |
| Smiths Sealants Ltd | Construction | 2015 |
| Smiths Timber Limited | Wholesale & retail | 2025 |
| Smjb Properties Limited | Real estate | 2020 |
| SML Holdings and Investments Ltd | Financial services | 2025 |
| Smooth Marketing Ltd | Professional & scientific | 2023 |
| SMP Estates Limited | Real estate | 2011 |
| SMS Service & Trading Ltd | Wholesale & retail | 2017 |
| SMT Vehicle Logistics Limited | Transport & logistics | 2007 |
| SMV Storage Solutions Ltd | Real estate | 2021 |
| SN Clinic Limited | Professional & scientific | 2022 |
| SN Communications (Midlands) Limited | Information & communication | 2024 |
| SN Investment Property Limited | Real estate | 2022 |
| Snab Assets Ltd | Professional & scientific | 2025 |
| Sntek Ltd | Professional & scientific | 2025 |
| Snug Loft Insulation Ltd | Construction | 2025 |
| Social Media Creations Limited | Professional & scientific | 2020 |
| Social Media Holdings and Investments Ltd | Financial services | 2025 |
| Sofa Connections Limited | Manufacturing | 1995 |
| Sofa Stop Limited | Wholesale & retail | 2025 |
| Softaxe Ltd | Information & communication | 2025 |
| Software Projects Limited | Information & communication | 2025 |
| Sohanoa Ltd | Health & social care | 2024 |
| Solarfit Blinds Limited | Manufacturing | 2007 |
| Solec Generation Ltd | Construction | 2023 |
| Soleil Cannock Ltd | Construction | 2024 |
| Soleil Properties Ltd | Real estate | 2025 |
| Solentra Children's Services Ltd | Health & social care | 2023 |
| Solentra Health Limited | Health & social care | 2024 |
| Solentra Support Group Ltd | Health & social care | 2023 |
| Solivia Group Ltd | Hospitality | 2010 |
| Solozone Limited | Manufacturing | 2025 |
| Solperkins Limited | Professional & scientific | 2005 |
| Some Like IT Hot 2 Limited | Hospitality | 2025 |
| Somnus Dreams Ltd | Manufacturing | 2020 |
| Somoniph Ltd | Administrative & support | 2019 |
| Sonailz Ltd | Other services | 2024 |
| Songstar Studio Limited | Information & communication | 2025 |
| Sophias Holistic Health Limited | Health & social care | 2024 |
| Sophie Gill Aesthetics Ltd | Other services | 2023 |
| Sophion Consulting Ltd | Professional & scientific | 2025 |
| Sosharp Detailing Limited | Other services | 2021 |
| Soul Revolution Festival Ltd | Education | 2021 |
| Soulstride Limited | Wholesale & retail | 2025 |
| South Installations Limited | Construction | 2003 |
| South Lawns Development Limited | Construction | 2024 |
| South Staffordshire Building Company Ltd | Construction | 2025 |
| South Staffs Driveways & Civil Engineering Limited | Construction | 2025 |
| South Staffs Industries Limited | Manufacturing | 1991 |
| Sovereign Court (Coventry) Management Company Limited | Households | 2007 |
| Sovran Parfum Ltd | Wholesale & retail | 2026 |
| SP Electrocoat Ltd | Professional & scientific | 2025 |
| SP Macbeth 5 Limited | Financial services | 2012 |
| SP Property Group Ltd | Real estate | 2025 |
| Space and Room Limited | Administrative & support | 2006 |
| Spacious Places CIC | Professional & scientific | 2026 |
| Spanglish-Hire Ltd | Transport & logistics | 2011 |
| Sparkledot Ltd | Wholesale & retail | 2026 |
| SPB Consultants Limited | Other services | 2021 |
| Specialist Sports Cars Ltd | Wholesale & retail | 2021 |
| Specialist Vehicle Conversions Ltd. | Wholesale & retail | 2015 |
| Specialist Vehicle Rental Solutions Ltd. | Administrative & support | 2017 |
| Specs and Lens Ltd | Health & social care | 2023 |
| Spectrum FM Ltd | Professional & scientific | 2017 |
| Speedy Shop 24/7 Ltd | Wholesale & retail | 2025 |
| Spenviark Manufacturing Limited | Financial services | 2022 |
| Spiceworlds Food Ltd | Hospitality | 2018 |
| Spiderland Limited | Information & communication | 2002 |
| Spinflexer Ltd | Wholesale & retail | 2019 |
| Spire Transport Services Limited | Transport & logistics | 2020 |
| Spires Maintenance Services Ltd | Extraterritorial | 2018 |
| Spirit and Sound CIC | Information & communication | 2025 |
| Spot on Car Sales Ltd | Wholesale & retail | 2025 |
| Spot on Lets Ltd | Real estate | 2022 |
| Spring Blossom Developments Limited | Construction | 2006 |
| Springboard Funding Ltd | Financial services | 2022 |
| Sprinter Transport Ltd | Transport & logistics | 2021 |
| Sprucehill Limited | Real estate | 1981 |
| Square Facades Limited | Manufacturing | 2019 |
| Square Lettings Ltd | Real estate | 2025 |
| Squawk Technologies Ltd | Information & communication | 2018 |
| Squire Thomas Limited | Construction | 2020 |
| SR Engineering Dudley Ltd | Professional & scientific | 2025 |
| SRC Fire M & E Limited | Construction | 2015 |
| SRC Fire Safety Limited | Construction | 2015 |
| SRP Direct Ltd | Real estate | 2025 |
| SRQ Consultancy Ltd | Financial services | 2018 |
| SS Campers Ltd | Manufacturing | 2025 |
| SSE Care Limited | Other services | 2016 |
| SSF Holdings Limited | Financial services | 2025 |
| SSH2 Limited | Information & communication | 2019 |
| SSN Foods Ltd | Hospitality | 2019 |
| SST Resources Limited | Financial services | 2012 |
| Sstarslongtermsupport Limited | Health & social care | 2025 |
| Sstop Limited | Wholesale & retail | 2023 |
| ST Barber Ltd | Other services | 2025 |
| ST Gym Group Limited | Arts & recreation | 2015 |
| ST Johns Road Dudley Ltd | Real estate | 2025 |
| ST Joseph Prudent Limited | Public administration | 2021 |