| ST Michaels Healthcare Limited | Health & social care | 2015 |
| ST Thomas's Community Association C.I.C. | Other services | 2025 |
| ST. George's Care Ltd. | Health & social care | 1986 |
| ST. Michael's Care Ltd. | Health & social care | 1991 |
| Staffordshire Construction Ltd | Construction | 2022 |
| Staffordshire Septics and Drainage Ltd | Construction | 2017 |
| Stainless Pipeline Solutions Limited | Wholesale & retail | 2010 |
| Stallings Lane Car Spares Limited | Wholesale & retail | 2003 |
| Stan Landes Ltd | Administrative & support | 2020 |
| Stan Mullin Fixings Limited | Administrative & support | 2007 |
| Standard Accountancy Ltd | Professional & scientific | 2016 |
| Standings Inspire Academy Limited | Other services | 2026 |
| Stanley Whittaker Limited | Construction | 2008 |
| Star Communications Ltd | Information & communication | 2001 |
| Star Delta Electrical Ltd | Construction | 2025 |
| Star Group Collective Ltd | Professional & scientific | 2026 |
| Star Internet Ltd | Information & communication | 2011 |
| Star Micro Ltd | Construction | 2017 |
| Star Outlet Store Ltd | Wholesale & retail | 2025 |
| Star Wines Ltd | Wholesale & retail | 2024 |
| Starfish (Warwick) Limited | Hospitality | 2020 |
| Stark Associates Ltd | Real estate | 2020 |
| Starlink Healthcare Ltd | Health & social care | 2019 |
| Starlit Recruitment Limited | Other services | 2016 |
| Starmac Holdings and Investments Ltd | Financial services | 2024 |
| Starmac Property Investments Ltd | Real estate | 2024 |
| Starmac Surfacing Ltd | Construction | 2014 |
| Startright Training Limited | Education | 2010 |
| Static Caravan Supply Ltd | Extraterritorial | 2026 |
| Station Facilities Limited | Administrative & support | 2014 |
| Steadfast Surveying Limited | Professional & scientific | 2017 |
| Stealth Improvement Ltd. | Information & communication | 2019 |
| Steedsman Limited | Manufacturing | 1995 |
| Steel & Site (Holdings) Limited | Real estate | 2014 |
| Steel Solutions (Midlands) Limited | Wholesale & retail | 2025 |
| Steelfix Site Installations Limited | Construction | 2016 |
| Steelflex Door Company Ltd | Manufacturing | 2025 |
| Steelstrip Holdings Limited | Financial services | 2022 |
| Steelstrip Services Limited | Manufacturing | 2003 |
| Stef Pro Services Ltd | Construction | 2019 |
| Stellar Mind Limited | Professional & scientific | 2018 |
| Step to Success Tuition With AS Ltd | Education | 2025 |
| Stereorb Ltd | Arts & recreation | 2024 |
| Sterling Quality Care Ltd | Health & social care | 2025 |
| Steve Baugh Drylining Limited | Construction | 2015 |
| Steve Bridges Homes Ltd | Construction | 2015 |
| Steve Hands Limited | Professional & scientific | 2008 |
| Steve Hickman Maintenance Services Limited | Manufacturing | 2018 |
| Steve Taylor Flooring Ltd | Construction | 2024 |
| Steve's Superwhip Limited | Wholesale & retail | 2026 |
| Steven Paul Contractors Limited | Construction | 1982 |
| Sthelven Company Limited | Real estate | 2013 |
| Stock Green Dog Groomers Limited | Other services | 2016 |
| Stockflip Ltd | Wholesale & retail | 2026 |
| Stokes Forgings Limited | Extraterritorial | 1939 |
| Stokes Scaffolding Solutions (2025) Limited | Construction | 2025 |
| Stonehart PVT Limited | Wholesale & retail | 2023 |
| Stoneleigh Care Homes Limited | Administrative & support | 2002 |
| Stoneleigh Timber Supplies Ltd | Wholesale & retail | 2020 |
| Storage World (Wolverhampton) Limited | Administrative & support | 2015 |
| Stories by Laviya Ltd | Professional & scientific | 2025 |
| Story Time Beds Ltd | Wholesale & retail | 2016 |
| Stourbridge Funeral Services Limited | Professional & scientific | 2000 |
| Stourbridge Holdings Ltd | Financial services | 2024 |
| Stourbridge Paving Company Limited | Construction | 1965 |
| Stourbridge Steels Ltd | Wholesale & retail | 2019 |
| Stourton Home Solutions Ltd | Construction | 2026 |
| Stoutfellows Limited | Hospitality | 2011 |
| Straits Mobility Services Limited | Wholesale & retail | 2011 |
| Stratton Partners Ltd | Administrative & support | 2025 |
| Strazile Ltd | Transport & logistics | 2022 |
| Streetly Stores Ltd | Wholesale & retail | 2013 |
| Strive on Ltd | Information & communication | 2024 |
| Stroud Rugby Limited | Arts & recreation | 2016 |
| Structural & Mechanical Supplies Limited | Wholesale & retail | 1991 |
| Structural Steelwork Limited | Manufacturing | 2010 |
| Structured Investment Midlands Limited | Real estate | 2016 |
| Strutech Design Limited | Other services | 2008 |
| Stuart Brown Painters Limited | Construction | 2004 |
| Stuart Spencer Limited | Wholesale & retail | 1959 |
| Studio 21 Beauty Ltd | Other services | 2021 |
| Studio 21 Hair Design Ltd | Other services | 2021 |
| Studio 263 Ltd | Professional & scientific | 2024 |
| Studio Bolt Limited | Information & communication | 2024 |
| Studio DM Unisex Hair Salon Ltd | Other services | 2019 |
| Stuka Holdings Ltd | Financial services | 2021 |
| Sturston One Limited | Professional & scientific | 2015 |
| Stygian FOX Publishing Ltd | Information & communication | 2019 |
| Stylish Sofas Ltd | Wholesale & retail | 2025 |
| Styllos Enterprises Ltd | Extraterritorial | 2020 |
| Suam H Limited | Real estate | 2024 |
| Suasive Associates Ltd | Real estate | 2014 |
| Suavesy Limited | Manufacturing | 2017 |
| Succeeding With Dyslexia Ltd | Health & social care | 2016 |
| Sugarspell Ltd | Wholesale & retail | 2025 |
| Sugo (Friar ST) Limited | Hospitality | 2018 |
| SUI Holdings Ltd | Financial services | 2024 |
| Sukserd Game Ltd | Information & communication | 2025 |
| Sullyvan Management Consultancy Limited | Professional & scientific | 2026 |
| Sumad Properties Ltd | Real estate | 2019 |