| Shockzy Ltd | Administrative & support | 2024 |
| Shooting Sports UK (Oakedge) Ltd | Wholesale & retail | 2022 |
| Shooting Sports UK Limited | Wholesale & retail | 2017 |
| Shop Magnificent Ltd | Wholesale & retail | 2025 |
| SHQIPONJA2 Limited | Hospitality | 2024 |
| Shrewsbury Electrical Contractors Ltd | Construction | 2012 |
| Shropshire Ltd | Wholesale & retail | 2025 |
| Shubhdeep Courier Limited Limited | Transport & logistics | 2024 |
| SHW Packaging Limited | Manufacturing | 2018 |
| SI Medicare Ltd | Health & social care | 2020 |
| SI Treat Ltd | Health & social care | 2018 |
| Side by Side Live-In-Care Limited | Public administration | 2020 |
| Sidfade Ltd | Other services | 2018 |
| Sign Synergy Limited | Wholesale & retail | 2011 |
| Signature Aromas Limited | Other services | 2002 |
| Signature Clinical Waste Ltd | Water & waste | 2021 |
| Signature Darts Ltd | Wholesale & retail | 2025 |
| Signature Drain Services Ltd | Administrative & support | 2025 |
| Signature Fitness Ltd | Arts & recreation | 2018 |
| Signature Window and Door Company Ltd | Construction | 2020 |
| Signaturegoods Ltd | Wholesale & retail | 2023 |
| Silkshutdown Events Ltd | Arts & recreation | 2022 |
| Silksoft AI Ltd | Wholesale & retail | 2025 |
| Silo Digital Ltd | Information & communication | 2021 |
| Silver Hill (Dudley) Limited | Hospitality | 2021 |
| Silver Stone Realty Ltd | Real estate | 2023 |
| Silver Wing Collectables Limited | Wholesale & retail | 2025 |
| Silverback Tyres Ltd | Wholesale & retail | 2021 |
| Silverthorne Engineering Company Limited | Manufacturing | 1993 |
| Silverthorne Holdings Limited | Financial services | 2020 |
| Silverthorne Properties Limited | Real estate | 2004 |
| Simco Construction Ltd | Construction | 2011 |
| Simco Investments Ltd | Other services | 2020 |
| Simco Properties Ltd | Real estate | 2016 |
| Simel Property Ltd | Real estate | 2025 |
| Simlico Limited | Information & communication | 2021 |
| Simon & Sophia Options Ltd | Health & social care | 2023 |
| Simon Chalk Limited | Arts & recreation | 2014 |
| Simon Pearce Plumbing & Heating Limited | Construction | 2005 |
| Simon White Limited | Other services | 2003 |
| Simon-Hartley Limited | Extraterritorial | 2025 |
| Simpatico Town Planning Limited | Professional & scientific | 2019 |
| Simple Handrails and Balustrades Ltd | Manufacturing | 2024 |
| Simplex Copperware Limited | Wholesale & retail | 2010 |
| Simply Cleaner Limited | Administrative & support | 2017 |
| Simply Living Properties Ltd | Real estate | 2025 |
| Simplyfmcg Limited | Wholesale & retail | 2025 |
| Simpson Security Services Ltd | Administrative & support | 2026 |
| Simtekbm Ltd | Wholesale & retail | 2011 |
| Since 4 Properties Ltd | Real estate | 2026 |
| Sing IT Ltd | Information & communication | 2013 |
| Singh Drinks Stop Ltd | Wholesale & retail | 2025 |
| Singh Transportation Limited | Transport & logistics | 2018 |
| Singhfreer Marketing Ltd | Wholesale & retail | 2023 |
| Singularity Steel Solutions Ltd | Manufacturing | 2026 |
| SIP Box UK Ltd | Hospitality | 2022 |
| Sistersoul Service Ltd | Other services | 2019 |
| Site CQA Limited | Construction | 2019 |
| Sitemark Limited | Administrative & support | 2006 |
| Sixways Logistics Ltd | Transport & logistics | 2019 |
| Sizzling Grill (West Midlands) Ltd | Hospitality | 2025 |
| SJB Fire & Security Limited | Administrative & support | 2025 |
| SJB Transport Solutions (Midlands) Ltd | Transport & logistics | 2023 |
| SJD Building and Maintenance Ltd | Construction | 2018 |
| SJD Holdings and Investments Ltd | Financial services | 2019 |
| SJD Installations Limited | Construction | 2008 |
| SJH Property (Midlands) Ltd | Households | 2023 |
| SK Cards UK Ltd | Wholesale & retail | 2023 |
| SK D'Grand Cabana UK Limited | Hospitality | 2017 |
| SK Prime Healthcare UK Ltd | Health & social care | 2023 |
| SKA Construction (UK) Ltd | Construction | 2025 |
| Skillbuilders Training Centre Ltd | Professional & scientific | 2024 |
| Sky Rozh Limited | Other services | 2014 |
| Sky Uniforms Limited | Wholesale & retail | 2012 |
| Skyglo Whales Limited | Wholesale & retail | 2023 |
| Skyrise Scaffolding Ltd | Construction | 2018 |
| Skyways Executive Travel Limited | Transport & logistics | 2022 |
| SL Roofline Limited | Construction | 2023 |
| Slater Tangent Limited | Wholesale & retail | 1993 |
| Sleek Services Limited | Administrative & support | 2004 |
| Slipability Limited | Manufacturing | 2024 |
| Slipbyslip Limited | Manufacturing | 2024 |
| Slntstreetwear Limited | Wholesale & retail | 2025 |
| Slothpoppy Ltd | Wholesale & retail | 2024 |
| Small Business Consultancy Limited | Administrative & support | 2015 |
| Small Style Ltd | Other services | 2025 |
| Smallman Stores Limited | Wholesale & retail | 2023 |
| Smart Art Properties Limited | Real estate | 1991 |
| Smart Builds Limited | Construction | 2009 |
| Smart Car Valeting Centre Limited | Administrative & support | 2015 |
| Smart Vape Ltd | Wholesale & retail | 2026 |
| Smartt Choice Ltd | Wholesale & retail | 2020 |
| Smartzone Solutions Ltd | Information & communication | 2022 |
| SMB Property Developments Ltd | Real estate | 2026 |
| Smbm Properties Ltd | Construction | 2020 |
| SMC Business Consultants Ltd | Professional & scientific | 2024 |
| Smestow Properties Limited | Real estate | 2019 |
| SMH Bathrooms and Boilers Ltd | Construction | 2026 |
| Smilingsoul Limited | Information & communication | 2020 |
| Smith Incorporated Ltd | Construction | 2020 |