| Sedgley Barber Ltd | Other services | 2022 |
| Sedgley Building & Paving Limited | Construction | 2017 |
| Sedgley Car Sales Ltd | Wholesale & retail | 2024 |
| Sedgley Control Systems Ltd | Professional & scientific | 2014 |
| Sedgley Dental Care Ltd | Health & social care | 2026 |
| Sedgley Painting Contractors Limited | Other services | 2016 |
| Sedgley Property Ltd | Real estate | 2024 |
| Sedgley Service Station Ltd | Wholesale & retail | 2020 |
| Sedgley Therapy Services Limited | Health & social care | 2022 |
| Seed Holdings and Investments Ltd | Financial services | 2026 |
| Seeley Retail Limited | Wholesale & retail | 2021 |
| Seja Holdings Ltd | Real estate | 2019 |
| Seja Ltd | Professional & scientific | 2017 |
| Select Health Care Specialist Limited | Administrative & support | 2019 |
| Sellers Properties Limited | Real estate | 2008 |
| Selling Synergy Ltd | Professional & scientific | 2024 |
| Selly Oak Lettings Limited | Real estate | 2022 |
| Semaker Ltd | Administrative & support | 2022 |
| Senday Limited | Education | 2026 |
| Senfina Scents Ltd | Wholesale & retail | 2025 |
| Senmoh Ltd | Wholesale & retail | 2023 |
| Sentry Developments (Holdings) Limited | Real estate | 1975 |
| SEO Nuts Limited | Information & communication | 2012 |
| SEP Corporation Limited | Extraterritorial | 2002 |
| SEP Estates Limited | Extraterritorial | 2002 |
| SEP Group Limited | Extraterritorial | 2002 |
| SEP Holdings Limited | Extraterritorial | 2002 |
| SEP Properties Limited | Real estate | 1986 |
| SEP Property Group Limited | Extraterritorial | 2002 |
| SEP Property Management Limited | Extraterritorial | 2002 |
| SEP Refurbishment Limited | Construction | 1994 |
| SEP Registry Limited | Extraterritorial | 2002 |
| SEP Securities Limited | Extraterritorial | 2002 |
| SEP Syndicates 21 Limited | Real estate | 2004 |
| SEP Syndicates 22 Limited | Extraterritorial | 2010 |
| Separator Solutions Limited | Water & waste | 2019 |
| Sepor Limited | Extraterritorial | 2007 |
| Seraph Care (BP) Ltd | Administrative & support | 2016 |
| Seren Plus Limited | Wholesale & retail | 2011 |
| Serenity Air Ltd | Administrative & support | 2025 |
| Serenity Couriers Ltd | Transport & logistics | 2019 |
| Serenity Path Care Ltd | Health & social care | 2022 |
| Serenna Beauty Ltd | Wholesale & retail | 2025 |
| Sergiu's Solutions Ltd | Construction | 2017 |
| Serter Holdings Limited | Financial services | 2019 |
| Serter Medical Limited | Manufacturing | 2000 |
| Serter Tooling Limited | Manufacturing | 2013 |
| Serve to Sell Ltd | Administrative & support | 2019 |
| Setia Estates Ltd | Real estate | 2025 |
| Setia Holdings and Investments Ltd | Financial services | 2026 |
| Setia Property Management Ltd | Real estate | 2026 |
| SEV Pure Touch Services Ltd | Administrative & support | 2025 |
| Seva Health Limited | Wholesale & retail | 2023 |
| Seva Properties Ltd | Real estate | 2023 |
| Seven Monkeys Logistic Ltd | Transport & logistics | 2019 |
| Seven Seas T/A Brecks Ltd | Hospitality | 2016 |
| SEVEN2ELEVEN Ltd | Wholesale & retail | 2023 |
| SEVEN6TWO Ltd | Information & communication | 2018 |
| Severn Valley Sand & Gravel Co.Limited | Real estate | 1943 |
| SF Property Management & Maintenance Ltd | Construction | 2025 |
| Sfupvc Roofing Contractors Ltd | Construction | 2021 |
| SG Business Consulting Ltd | Professional & scientific | 2026 |
| SGS Courier 365 Limited | Transport & logistics | 2025 |
| SGT Europe Limited | Administrative & support | 2015 |
| SH Wares & General Limited | Wholesale & retail | 2024 |
| Shaheen Healthcare Limited | Wholesale & retail | 2023 |
| Shaheen Transport Limited | Transport & logistics | 2019 |
| Shake House Dudley Limited | Manufacturing | 2022 |
| Shaket Technical Services Limited | Professional & scientific | 2013 |
| Shakkur and Co Ltd | Hospitality | 2025 |
| Shale Inns Limited | Hospitality | 2019 |
| Shalmaz Limited | Wholesale & retail | 2025 |
| Shalom Painting, Decorating and Laminating Limited | Construction | 2023 |
| Shannon Installations Limited | Construction | 2013 |
| Shaperite Profiles (Holdings) Limited | Professional & scientific | 2011 |
| Shaperite Profiles Limited | Manufacturing | 1977 |
| Sharif & Sons Food Section Ltd | Hospitality | 2024 |
| Sharmar Consultancy Limited | Professional & scientific | 2023 |
| Sharp Events Group Limited | Construction | 2017 |
| Shaw's Auto Traders Ltd | Wholesale & retail | 2017 |
| Shbookkeeping Ltd | Professional & scientific | 2022 |
| Sheb Property Management Limited | Households | 2025 |
| Sheikh Foodie Limited | Hospitality | 2025 |
| Shelby Automotive Midlands Ltd | Administrative & support | 2021 |
| Shelby Tattoos & Grooming Limited | Other services | 2019 |
| Shelby's MOT Centre Ltd | Wholesale & retail | 2021 |
| Sheldmores Limited | Professional & scientific | 2017 |
| Shemur Security Solutions Ltd | Administrative & support | 2004 |
| Shenstone Cars Limited | Wholesale & retail | 2024 |
| Sher Logistics Ltd | Transport & logistics | 2024 |
| Sherborne Court Neurological Centre Ltd | Health & social care | 2012 |
| SHG Lettings Ltd | Real estate | 2026 |
| Shieldsafe Security Ltd | Financial services | 2024 |
| Shifnal Town FC Limited | Arts & recreation | 2019 |
| Shift Employment Ltd | Administrative & support | 2012 |
| Shilan Hairdresser Ltd | Other services | 2025 |
| Shiloh Clinics Limited | Health & social care | 2021 |
| Shiralkar Limited | Professional & scientific | 2008 |
| SHK Trading Ltd | Wholesale & retail | 2024 |
| Shloi Limited | Manufacturing | 2006 |