| SA Enterprises WM Ltd | Wholesale & retail | 2026 |
| Saab Traders Ltd | Wholesale & retail | 2021 |
| Sabri Tech Ltd | Information & communication | 2025 |
| Saco Heritage Ltd | Wholesale & retail | 2025 |
| Sadiq Consultants Limited | Wholesale & retail | 2009 |
| Safe 4 Life Driver Training Limited | Education | 2008 |
| Safe Heat GAS & Plumbing Ltd | Construction | 2018 |
| Safe Heaven Builders Ltd | Construction | 2025 |
| Safe Hourbour Housing Ltd | Hospitality | 2026 |
| Safe N Tidy Limited | Administrative & support | 2012 |
| Safe Response GAS & Plumbing Ltd | Construction | 2016 |
| Safecross Limited | Professional & scientific | 1988 |
| Safety Autos Ltd | Wholesale & retail | 2018 |
| Safety NET Fire Solutions Ltd | Construction | 2024 |
| Saffron Fine Indian Takeaway Ltd | Hospitality | 2023 |
| Sage Cleanse Ltd | Administrative & support | 2025 |
| Sahota Social Care Solutions Ltd | Health & social care | 2024 |
| Saima Rayyan Limited | Other services | 2018 |
| Saint Clair Holdings Ltd | Financial services | 2026 |
| Saint George's Georgian Society of Birmingham and West Midlands Ltd | Other services | 2012 |
| Saint Philips Limited | Financial services | 2022 |
| Salesspark Limited | Real estate | 2020 |
| Salon.Ice Ltd | Other services | 2019 |
| Salopian Flyfishers Association Limited | Arts & recreation | 1978 |
| Salt Electrical Solutions Ltd | Construction | 2021 |
| Saltmine Trust | Arts & recreation | 1994 |
| SAM Rabone Artist Ltd | Arts & recreation | 2011 |
| Sambee Care Services Limited | Health & social care | 2026 |
| Sammi (UK) Limited | Health & social care | 2012 |
| Sammi Care Homes Limited | Health & social care | 2012 |
| Samuel Eggington Limited | Arts & recreation | 2016 |
| Samuel Parkes (Builders) Limited | Professional & scientific | 1944 |
| Samuel Parkes (Estates) Limited | Construction | 1964 |
| Samuelb Ltd | Health & social care | 2010 |
| Sandhawk Consulting Ltd | Information & communication | 2022 |
| Sandown Close Management Company Limited | Extraterritorial | 2022 |
| Sandra Ralph Racing Ltd | Arts & recreation | 2017 |
| Sands Holdings Midlands Ltd | Financial services | 2024 |
| Sandsy's of Sedgley Ltd | Hospitality | 2024 |
| Sanduzav Limited | Administrative & support | 2017 |
| Sandwell Gym Ltd | Arts & recreation | 2022 |
| Sandwell Stripping Limited | Water & waste | 2001 |
| Sandy Singh Ltd | Transport & logistics | 2024 |
| Sankey Farms Holdings & Investments Ltd | Financial services | 2023 |
| Sankey Farms Ltd | Agriculture & fishing | 2023 |
| Sanni BIN Limited | Manufacturing | 2025 |
| Sanod Limited | Wholesale & retail | 2026 |
| Sansoy Company Ltd | Information & communication | 2022 |
| Santel Properties Ltd | Real estate | 2016 |
| Sanzibar Ltd | Hospitality | 2025 |
| SAP Aesthetics Ltd | Other services | 2021 |
| Sarah and Xavier Ltd | Professional & scientific | 2025 |
| Sarehole Road Limited | Health & social care | 2016 |
| Sash Cosmetics and Hair Extensions Limited | Wholesale & retail | 2018 |
| Sash Living Properties Ltd | Real estate | 2019 |
| Satplus Health Care Ltd | Health & social care | 2019 |
| Saturday Books Limited | Wholesale & retail | 2026 |
| Saunders Saddlery Ltd | Wholesale & retail | 1996 |
| Saver Express Limited | Wholesale & retail | 2014 |
| Savit Ltd | Transport & logistics | 2026 |
| Savlex Limited | Manufacturing | 1989 |
| Saxon & Co Accountants (Audit) Limited | Professional & scientific | 2025 |
| Saxon & Co Accountants (Practice) Ltd | Professional & scientific | 2025 |
| Saxon & Co Accountants Limited | Professional & scientific | 2021 |
| Saxons Limited | Professional & scientific | 2003 |
| SB 1 Ltd | Wholesale & retail | 2019 |
| SB Design & Builds Ltd | Construction | 2025 |
| SB Machine Vending Ltd | Wholesale & retail | 2025 |
| SB Transport Dudley Ltd | Transport & logistics | 2024 |
| SBC Construction U.K. Ltd | Construction | 2024 |
| SBL (UK) Developments Ltd | Construction | 2024 |
| SBL (UK) Homes Ltd | Construction | 2024 |
| SBL (UK) Training Academy Ltd | Education | 2024 |
| SBL UK Holdings Ltd | Financial services | 2024 |
| SBP Property and Investments Limited | Real estate | 2022 |
| SC Access Platforms Ltd | Manufacturing | 2023 |
| SC Construction Services Limited | Professional & scientific | 2024 |
| Scalarforge Ltd | Professional & scientific | 2025 |
| Scallywags Indoor Play Ltd | Arts & recreation | 2003 |
| Scalpay Limited | Information & communication | 1985 |
| Scarlet Dart Limited | Information & communication | 2018 |
| SCC Construction Ltd | Construction | 2020 |
| Schoolstube Global Ltd | Information & communication | 2019 |
| Scissoreyes Ltd | Administrative & support | 2019 |
| Scopetrack Limited | Information & communication | 2012 |
| SCP Car Storage Ltd | Other services | 2025 |
| Scribbled Space Properties Ltd | Real estate | 2020 |
| Sculptedpixel Ltd | Professional & scientific | 2023 |
| SD Fitness Limited | Arts & recreation | 2014 |
| SD Market Limited | Wholesale & retail | 2018 |
| Seaa Properties Ltd | Real estate | 2025 |
| Seaflo UK Ltd | Wholesale & retail | 2012 |
| Searchlight Theatre Company Limited | Arts & recreation | 2011 |
| Seasons Five Ltd | Hospitality | 2025 |
| Sebb Housing Ltd | Hospitality | 2023 |
| Sebcarcare Ltd | Wholesale & retail | 2018 |
| Sebd Group Ltd | Professional & scientific | 2020 |
| Securefix Direct Ltd | Wholesale & retail | 2017 |
| Sedgley Accounting and Business Services Limited | Professional & scientific | 2021 |
| Sedgley Auto Centre Limited | Wholesale & retail | 2011 |