| Shubho Kundu Wealth Management Limited | Financial services | 2022 |
| SID Group Ltd | Wholesale & retail | 2021 |
| Sidat Solutions Limited | Health & social care | 2025 |
| Side Chiick Ltd | Hospitality | 2023 |
| Sidings Healthcare Limited | Health & social care | 2022 |
| Sienna Living Ltd | Wholesale & retail | 2021 |
| Siesta Living Ltd | Wholesale & retail | 2021 |
| Signature Marquees and Lighting Ltd | Administrative & support | 2025 |
| Silk & Lace Ltd | Manufacturing | 2019 |
| Silk Route Flavours Limited | Wholesale & retail | 2025 |
| Silk Siesta Ltd | Manufacturing | 2026 |
| Silver Birch Group Ltd | Financial services | 2026 |
| Silver Lines Medical Ltd | Health & social care | 2020 |
| Simi Retails Limited | Wholesale & retail | 2025 |
| Simpli Smart Ltd | Wholesale & retail | 2015 |
| Simplicitysells Ltd | Wholesale & retail | 2023 |
| Simply GET Limited | Wholesale & retail | 2025 |
| Simplystools Ltd | Wholesale & retail | 2026 |
| SIP Enterprises Ltd | Professional & scientific | 2018 |
| SIP Wakefield Limited | Hospitality | 2023 |
| SIS (Ashton) Ltd | Arts & recreation | 2015 |
| Sisters of Barakah Limited | Wholesale & retail | 2024 |
| Sizzling Tawa House Ltd | Hospitality | 2025 |
| SJ Dream Beds Limited | Manufacturing | 2018 |
| Sj-Rapidtrans Limited | Transport & logistics | 2018 |
| SJP Consulting Services Ltd | Professional & scientific | 2023 |
| SK Fixed IT Ltd | Wholesale & retail | 2025 |
| SK Living Limited | Real estate | 2026 |
| SK Soultions Ltd | Health & social care | 2024 |
| Skilltrail Ltd | Wholesale & retail | 2025 |
| Skopos Fabrics Limited | Manufacturing | 2015 |
| Sktw Ventures Limited | Wholesale & retail | 2019 |
| Skyenergi Limited | Extraterritorial | 2024 |
| Skymode Travel Ltd | Administrative & support | 2025 |
| Skystone BED Ltd | Manufacturing | 2025 |
| SL Foods Catering Limited | Hospitality | 2025 |
| SL Services Dewsbury Ltd | Professional & scientific | 2016 |
| Slab & Slice Co Ltd | Manufacturing | 2025 |
| Sleek Ophthalmic Solutions Limited | Health & social care | 2015 |
| Sleep Care Ltd | Manufacturing | 2025 |
| Sleep Caster Group Limited | Manufacturing | 2022 |
| Sleep Comfort Ltd | Manufacturing | 2026 |
| Sleep Dove Beds Ltd | Manufacturing | 2020 |
| Sleep Express Ltd | Wholesale & retail | 2015 |
| Sleep King Ltd | Wholesale & retail | 2020 |
| Sleep Therapy Ltd | Wholesale & retail | 2026 |
| Sleep Village Ltd | Wholesale & retail | 2017 |
| Sleep&Bed Ltd | Wholesale & retail | 2021 |
| SLEEP95 Ltd | Wholesale & retail | 2025 |
| Sleepdomi Ltd | Wholesale & retail | 2024 |
| Sleeperzzz Bespoke Beds Ltd | Wholesale & retail | 2026 |
| Sleeptogo Ltd | Wholesale & retail | 2025 |
| Sleepwell Bespoke Beds Ltd | Manufacturing | 2024 |
| Sleepy Bedz Ltd | Wholesale & retail | 2020 |
| Sleepy Ltd | Wholesale & retail | 2025 |
| Sleepy Nights Limited | Wholesale & retail | 2019 |
| Sleepy Panda Ltd | Wholesale & retail | 2020 |
| Slice & Spice (Yorkshire) Ltd | Hospitality | 2025 |
| Slimaney Ltd | Wholesale & retail | 2025 |
| Sloomy Ltd | Wholesale & retail | 2022 |
| Slumber Haven Limited | Wholesale & retail | 2025 |
| Slumberease Ltd | Manufacturing | 2025 |
| SM Corporation Ltd | Other services | 2020 |
| SM Diamond Properties Ltd | Real estate | 2019 |
| SMA Properties Hub Ltd | Real estate | 2024 |
| SMA Property Partners Ltd | Real estate | 2025 |
| Smak Associates Ltd | Information & communication | 2009 |
| Smallwood PHR Ltd | Manufacturing | 2016 |
| Smart Barbers Thornill Limited | Other services | 2023 |
| Smart Cabs Ltd | Transport & logistics | 2025 |
| Smart Holdings UK Ltd | Professional & scientific | 2008 |
| Smart Media Finance Ltd | Other services | 2017 |
| Smart Savings Limited | Wholesale & retail | 2025 |
| Smart Sleeping Ltd | Wholesale & retail | 2019 |
| Smart Tech Trading Ltd | Wholesale & retail | 2023 |
| Smartescapetravel Ltd | Administrative & support | 2026 |
| Smarttech Dewsbury Limited | Wholesale & retail | 2025 |
| Smartway Enterprise Ltd | Wholesale & retail | 2004 |
| Smashxd Ltd | Hospitality | 2025 |
| Smile Bar & Venue Limited | Hospitality | 2021 |
| Smile Promotions Yorkshire Ltd | Arts & recreation | 2023 |
| Smile Radio Yorkshire CIC | Information & communication | 2020 |
| Smith Property Management Ltd | Real estate | 2019 |
| Smokys Pizzas Ltd | Hospitality | 2024 |
| SN LUX Ltd | Wholesale & retail | 2026 |
| SN Van Sales Ltd | Extraterritorial | 2016 |
| Snaa Property Ltd | Real estate | 2018 |
| Snack Hub (Huddersfield) Ltd | Professional & scientific | 2025 |
| Snake Eyes Group Limited | Wholesale & retail | 2017 |
| Snooz Beds Limited | Wholesale & retail | 2025 |
| Snooza Ltd | Wholesale & retail | 2024 |
| Snooze Components Ltd | Wholesale & retail | 2020 |
| Snooze Spot Ltd | Manufacturing | 2025 |
| Snoozeshuttle Ltd | Transport & logistics | 2025 |
| Snoozey Sleep Ltd | Manufacturing | 2024 |
| Snoozy Ltd | Wholesale & retail | 2026 |
| Snorlaxsleeps Ltd | Wholesale & retail | 2025 |
| Snowden Building Services Limited | Construction | 2026 |
| Snowfall Investments Limited | Real estate | 2023 |
| Snugglezzz Ltd | Wholesale & retail | 2025 |