| Salman Digitals Ltd | Wholesale & retail | 2025 |
| Sam's MOT Centre Ltd | Wholesale & retail | 2020 |
| Sam.Sleep Ltd | Wholesale & retail | 2017 |
| Samata Reform Ltd | Arts & recreation | 2025 |
| Samcollectionz Ltd | Wholesale & retail | 2025 |
| Sancorp Car Accident Replacements Ltd | Administrative & support | 2024 |
| Sandal Works Ltd | Wholesale & retail | 2025 |
| Sands Lane Holdings Limited | Financial services | 2023 |
| Sands Lane Limited | Professional & scientific | 2015 |
| Sanford Hill Ltd | Construction | 2020 |
| Santos Halal Food Ltd | Hospitality | 2023 |
| Sanwa UK Ltd | Manufacturing | 2004 |
| SAP Real Estate Ltd | Real estate | 2025 |
| Saqsal Limited | Wholesale & retail | 2025 |
| Sareer Furniture Limited | Manufacturing | 2014 |
| SAS Works PVT Ltd | Construction | 2026 |
| Saturn Distribution Services Limited | Transport & logistics | 2002 |
| SAV Estate Ltd | Real estate | 2021 |
| SAV Pet Ltd | Real estate | 2020 |
| SAV Radu Ltd | Construction | 2022 |
| Savile Distributors UK Ltd | Wholesale & retail | 2025 |
| Savile Distro Ltd | Transport & logistics | 2025 |
| Savile Enterprises Ltd | Real estate | 2011 |
| Savile Medical Centre Limited | Health & social care | 2005 |
| Savile Petroleum Limited | Wholesale & retail | 2004 |
| Savile Town Wharf Limited | Manufacturing | 2020 |
| Savyshop Ltd | Wholesale & retail | 2025 |
| Saxony Living Ltd | Wholesale & retail | 2023 |
| Saythankyou Ltd | Wholesale & retail | 2020 |
| SB & RB UK Limited | Other services | 2020 |
| Scarborough Thornhill Ltd | Hospitality | 2024 |
| Scarr END Mill Farm Estates Limited | Agriculture & fishing | 2011 |
| Scrubbed.World Ltd | Manufacturing | 2023 |
| Sdka Panels Limited | Wholesale & retail | 2025 |
| SDR Building Contractors Ltd | Construction | 2020 |
| Sds(Dewsbury) Limited | Hospitality | 2026 |
| Sea Dewsbury Ltd | Real estate | 2025 |
| Searby Group Ltd | Construction | 2026 |
| Search Deal Ltd | Information & communication | 2020 |
| Seco Properties Ltd | Real estate | 2016 |
| Secret Nights Limited | Arts & recreation | 2025 |
| Secure Mind Limited | Wholesale & retail | 2005 |
| Secureffort Locksmith Ltd | Construction | 2023 |
| Securestart Solutions Ltd | Administrative & support | 2025 |
| Seedat Renovation Limited | Construction | 2022 |
| Select Spraying & Decorating Ltd | Construction | 2020 |
| Selena Salon Ltd | Other services | 2024 |
| Sellusyourcarnow Ltd | Wholesale & retail | 2025 |
| Selsie Ltd | Wholesale & retail | 2018 |
| Senior Packaging Limited | Administrative & support | 2002 |
| Senmec Pipework Services Limited | Construction | 2015 |
| Sensanite Ltd | Manufacturing | 2026 |
| Sensory World CIC | Health & social care | 2018 |
| Sentience AI Ltd | Wholesale & retail | 2025 |
| Sentinel Vaults (Yorks) Ltd | Construction | 2020 |
| Serendibite Limited | Health & social care | 2024 |
| Serene Childrens Care Ltd | Health & social care | 2025 |
| SFS Developments Limited | Real estate | 1998 |
| SHA Tyres Ltd | Wholesale & retail | 2021 |
| Shabina Iram Limited | Health & social care | 2010 |
| Shafaqat Limited | Hospitality | 2025 |
| Shafi Estates Ltd | Real estate | 2026 |
| Shah International Food Store 1 Limited | Wholesale & retail | 2025 |
| Shah International Food Store Ltd | Wholesale & retail | 2020 |
| Shaheen Kausar Properties Ltd | Real estate | 2021 |
| Shahzado Saleem Ltd | Wholesale & retail | 2024 |
| Shake Street Ltd | Hospitality | 2023 |
| Shaks Travel Limited | Administrative & support | 2021 |
| Shalimar Catering Ltd | Hospitality | 2025 |
| Sham Ventures Ltd | Wholesale & retail | 2026 |
| Shamal Auto Limited | Wholesale & retail | 2026 |
| Shan Brothers Ltd | Hospitality | 2023 |
| Shanice Properties Ltd | Real estate | 2023 |
| Shariah Poultry Ltd | Wholesale & retail | 2018 |
| Shariah Vault Ltd | Financial services | 2025 |
| Shavers Salon/Barbers Limited | Other services | 2011 |
| Shaw Cross (Property) Ltd | Financial services | 2014 |
| Shawarma Keng 4U Ltd | Hospitality | 2023 |
| Shawcross Store Limited | Wholesale & retail | 2016 |
| Shaykhs Ltd | Construction | 2024 |
| Sheikh Fabrications Ltd | Manufacturing | 2025 |
| Shelby Logistics Group Ltd | Transport & logistics | 2023 |
| Sheldon Management Ltd | Real estate | 2025 |
| Shello Ltd | Health & social care | 2024 |
| Shewi Wholesale Ltd | Wholesale & retail | 2024 |
| Shifat Consultants Ltd | Health & social care | 2012 |
| Shine Bright Tutoring Trading AS KIP Mcgrath Education Centres Limited | Education | 2023 |
| Shine Hand Carwash U.K. Ltd | Other services | 2024 |
| Shining Beacons CIC | Health & social care | 2023 |
| Shipping Solutions Ltd | Wholesale & retail | 2015 |
| Shire Beds Estates Limited | Financial services | 2025 |
| Shire Beds Holdings Limited | Financial services | 2025 |
| Shire Beds Ltd | Manufacturing | 1997 |
| SHL Locums Ltd | Health & social care | 2026 |
| Shohib Consultants Limited | Administrative & support | 2015 |
| Shoky Limited | Real estate | 2012 |
| Shomaq Ltd | Wholesale & retail | 2012 |
| Shop Beds Ltd | Wholesale & retail | 2017 |
| Shop Craze Ltd | Wholesale & retail | 2024 |
| SHP Healthcare Limited | Other services | 2013 |