| Carcoon Worldwide Workstations Limited | Manufacturing | 1994 |
| Carl Johnson Limited | Administrative & support | 2002 |
| Carpenter Holdings Limited | Administrative & support | 2001 |
| Carpenter Limited | Manufacturing | 1926 |
| Carpet & Vinyl Centre (Clowne) Limited | Wholesale & retail | 2004 |
| Cars 2 YOU Ltd | Wholesale & retail | 2023 |
| Castle Building Contractors Limited | Construction | 1997 |
| Castle Donington Service Centre Limited | Wholesale & retail | 2005 |
| Castle Environmental Limited | Professional & scientific | 1995 |
| Castleton Garage (Derbyshire) Limited | Wholesale & retail | 1958 |
| Caving Supplies Limited | Wholesale & retail | 1983 |
| CAW Consulting Limited | Information & communication | 2003 |
| CCF Fibreglass Ltd | Manufacturing | 2023 |
| Celestial Creations Limited | Manufacturing | 2025 |
| Cell Security Limited | Manufacturing | 1988 |
| Central Midlands Alliance League Limited | Arts & recreation | 2024 |
| Cfcs Consulting Limited | Real estate | 2016 |
| Cfcs Property Management Limited | Real estate | 2017 |
| Chadwick Carpenter Limited | Professional & scientific | 2007 |
| Channel Z Films Inc. Limited | Professional & scientific | 1999 |
| Chapel-En-Le-Frith Amateur Players Holdings Limited | Arts & recreation | 1912 |
| Characc Limited | Extraterritorial | 2000 |
| Cheetham Associates Ltd | Professional & scientific | 1999 |
| Chelec Limited | Construction | 2007 |
| Chen's Catering Limited | Hospitality | 2021 |
| Chester Road (Poynton) Residents Management Company Limited | Households | 2020 |
| Chesterfield Cold Storage Company Limited | Financial services | 1974 |
| Chesterfield Football Club Limited | Arts & recreation | 2007 |
| Chesterfield Specsavers Limited | Wholesale & retail | 1994 |
| Chesterfield Visionplus Limited | Wholesale & retail | 1994 |
| Chestnut Centre Limited | Arts & recreation | 2022 |
| Children First Derby | Health & social care | 2005 |
| Chris Baldwin Agencies Limited | Wholesale & retail | 2002 |
| Chris Dawes Limited | Transport & logistics | 2004 |
| Chris Watson Mortgage & Protection Services Ltd | Financial services | 2024 |
| Cirrostratus 2 Limited | Financial services | 2023 |
| Clarke Interiors Limited | Administrative & support | 2006 |
| Clarkson Brown Limited | Hospitality | 2003 |
| Classy Deals Limited | Wholesale & retail | 2025 |
| Clayborne Design Limited | Administrative & support | 1999 |
| Clean & Pristine Limited | Administrative & support | 2008 |
| Clearest.Co.Uk Limited | Administrative & support | 2006 |
| Cleaver Thompson Limited | Professional & scientific | 2003 |
| Clerkson Hall Antiques Limited | Wholesale & retail | 1997 |
| Cliff College Outreach | Hospitality | 1988 |
| Clinic of Natural Medicine Limited | Professional & scientific | 2003 |
| Clipper Accounting Limited | Professional & scientific | 1981 |
| Clowns Day Nursery Limited | Education | 1999 |
| Cluny Lace Company Limited | Manufacturing | 1975 |
| Cocoon Storage Limited | Professional & scientific | 1999 |
| Colbere Engineering Limited | Manufacturing | 1973 |
| Colledge Properties Limited | Real estate | 1999 |
| Collie Properties Limited | Real estate | 2017 |
| Collingsgate Residents Management Company Limited | Households | 2019 |
| Combustion Engineering Ltd | Manufacturing | 1948 |
| Commercial Safety Inspections Limited | Professional & scientific | 2001 |
| Communication Consulting Limited | Information & communication | 2001 |
| Connected: Structural Steel Detailers Limited | Construction | 2018 |
| Connex Community Support | Health & social care | 1994 |
| Conveyor Belting and Accessories Limited | Wholesale & retail | 2004 |
| Corbar Towers Limited | Households | 1987 |
| Cosy Shepherd Huts (Tomlinson) Ltd | Hospitality | 2024 |
| County Gates Ltd. | Manufacturing | 2002 |
| COX Electrical Services Limited | Construction | 2002 |
| CPJ Short Stay Accommodation Ltd | Hospitality | 2023 |
| Craig Gray Limited | Construction | 2007 |
| CRE8IVE Station Ltd | Arts & recreation | 2006 |
| Creative Interiors Limited | Wholesale & retail | 2000 |
| Cressbrook Management Limited | Administrative & support | 1993 |
| Crest Masonry Limited | Other services | 2023 |
| Critchlows Limited | Wholesale & retail | 2003 |
| Crocker Bros. Limited | Manufacturing | 1965 |
| Crofter Construction Limited | Construction | 2005 |
| Croick Caledonian Limited | Financial services | 2003 |
| Cross Cliffe Properties Limited | Real estate | 2002 |
| Crossbow Rock Drills Limited | Manufacturing | 1999 |
| Crossfields Bloodstock Limited | Agriculture & fishing | 2007 |
| Crossfields Limited | Professional & scientific | 2003 |
| Crossfleet Limited | Manufacturing | 1998 |
| Crystal Clear Communications Limited | Professional & scientific | 1993 |
| Crystal Design & Developments Limited | Wholesale & retail | 2002 |
| CS Fleet Ltd | Manufacturing | 2021 |
| CSE Crosscom UK Limited | Financial services | 2019 |
| CSG Bodyshop Limited | Wholesale & retail | 2001 |
| Custom Cruisers Limited | Wholesale & retail | 1998 |
| Custom Curtain Company Limited | Extraterritorial | 1999 |
| Custom Group Limited | Manufacturing | 1987 |
| Cutting Edge NDT Ltd | Professional & scientific | 2001 |
| CW Electrical Renewables Ltd | Construction | 2023 |
| CY Enterprises Limited | Manufacturing | 2007 |
| D & E Billyeald Ltd | Wholesale & retail | 2003 |
| D & E Electrical Limited | Construction | 2007 |
| D & P Automotive Limited | Wholesale & retail | 2005 |
| D. Daniel Joinery Limited | Construction | 2004 |
| D. Kavanagh & SON Limited | Construction | 2002 |
| D.A.C. Fabrications Ltd | Professional & scientific | 2005 |
| D.B. Brooks (Electrical Engineers) Limited | Construction | 1994 |
| D.C.S. High Pressure Cleaning Limited | Administrative & support | 2002 |
| D.T. Cars Limited | Wholesale & retail | 2000 |
| Daisy Chain Day Nursery Limited | Education | 2006 |