| Dale Accounting Services Limited | Professional & scientific | 2006 |
| Dales Fabrications Limited | Manufacturing | 1980 |
| Danerock Limited | Financial services | 1983 |
| Danielle Wear Ltd | Wholesale & retail | 2026 |
| Dannah Farm Country House Limited | Hospitality | 2003 |
| Darley Moor Properties Limited | Real estate | 2007 |
| Dave Adams Ltd | Arts & recreation | 2002 |
| Davenport Upholstery Services Limited | Manufacturing | 2003 |
| David a Hancock Tarmacing Limited | Construction | 2003 |
| David G. Davies & Sons Limited | Transport & logistics | 1974 |
| David Gravett Limited | Information & communication | 2006 |
| David Hickie Limited | Professional & scientific | 2000 |
| David Hughes Denture Studio Limited | Health & social care | 2007 |
| David J Dowler Ceramics Limited | Construction | 2007 |
| Delish Dishes Limited | Hospitality | 2020 |
| Dempster Computer Services Limited | Information & communication | 1980 |
| Derbyshire Computer Services Ltd | Information & communication | 2018 |
| Derbyshire Historic Buildings Trust | Construction | 1974 |
| Derbyshire Limestone Limited | Manufacturing | 1987 |
| Derim Steels Limited | Wholesale & retail | 1978 |
| Derwent Carpets and Curtains Limited | Wholesale & retail | 1987 |
| Design Kitts Limited | Professional & scientific | 2007 |
| Design Network Services Limited | Information & communication | 1999 |
| Design Union UK Limited | Professional & scientific | 1999 |
| Devonshire House (Buxton) Limited | Households | 1999 |
| DFB Sound & Light Warehouse Ltd | Wholesale & retail | 2000 |
| DHM Consultants Limited | Administrative & support | 2005 |
| Diggle Services Ltd | Agriculture & fishing | 2006 |
| Digifix Limited | Professional & scientific | 2002 |
| Dilworth & Morris Limited | Real estate | 1934 |
| Diomyx Trading Limited | Manufacturing | 2025 |
| Direct Help & Advice Ltd. | Information & communication | 1998 |
| Direct Mail Order Marketing Limited | Professional & scientific | 2003 |
| Direct Office Training Limited | Administrative & support | 2003 |
| Distinctive Inns Limited | Hospitality | 2009 |
| Dixon Dean Limited | Professional & scientific | 2019 |
| Dixon Engineering Limited | Manufacturing | 1997 |
| Docs-Smith Limited | Information & communication | 2007 |
| Dodd Estates (UK) Ltd | Financial services | 2002 |
| Dogstar AV Limited | Arts & recreation | 2004 |
| Dolley Properties Limited | Real estate | 2024 |
| DON Derosa Motor Services Limited | Wholesale & retail | 2007 |
| Don's Taxis Limited | Transport & logistics | 2003 |
| Door Care and Security Limited | Construction | 1985 |
| Doug Richardson Consulting Limited | Professional & scientific | 2000 |
| Dove Valley LOO Hire Limited | Construction | 2006 |
| Dove Valley Plant Hire Limited | Construction | 2003 |
| Dovedale Garage Limited | Wholesale & retail | 2003 |
| DPM Flooring Limited | Wholesale & retail | 2007 |
| Dragon Technology Limited | Information & communication | 1997 |
| E & G Howe Limited | Other services | 2002 |
| E. Conway & Sons (Timber Sales) Limited | Wholesale & retail | 1972 |
| E. Cope & SON Limited | Construction | 2003 |
| E. Parry Electrical Installations Limited | Construction | 1979 |
| E.A.M. Software Services Ltd | Information & communication | 2006 |
| East Lancashire Chemical Company,Limited | Manufacturing | 1928 |
| East Midlands Event Services Ltd | Other services | 2017 |
| Eden Projects (Midlands) Limited | Extraterritorial | 2005 |
| Edyllic Properties Limited | Real estate | 2006 |
| EFW Projects Limited | Construction | 2024 |
| Electric Executive Rides Ltd | Transport & logistics | 2024 |
| Elements Music & Events Ltd | Arts & recreation | 2021 |
| Elliot House Limited | Real estate | 2004 |
| ELM Farm Ingleby (Watermeadow) Company Limited | Administrative & support | 2002 |
| Elmpharm Limited | Health & social care | 1999 |
| Empire Process Engineers Limited | Professional & scientific | 2002 |
| EMR Building Services Ltd | Construction | 2025 |
| Envacet Limited | Manufacturing | 2002 |
| EPC Chemicals Ltd | Manufacturing | 2022 |
| EPC Energetics Ltd | Manufacturing | 2026 |
| Erewash Community Transport Limited | Transport & logistics | 1996 |
| Errut Products Limited | Manufacturing | 1962 |
| ESC Holdings Limited | Water & waste | 2016 |
| Etta Plumbing and Heating Services Limited | Construction | 1996 |
| Eurofunding Holdings Limited | Professional & scientific | 2005 |
| Eurolink Electrical & Security Limited | Wholesale & retail | 2007 |
| Evans Innovations Limited | Manufacturing | 2007 |
| Event Hire Limited | Administrative & support | 2005 |
| Exbo Limited | Construction | 2001 |
| Excel Automation Agency Ltd | Information & communication | 2023 |
| Exikane Limited | Hospitality | 1991 |
| Exlen Technology Limited | Wholesale & retail | 1997 |
| Exotic Hardwoods (UK) Limited | Wholesale & retail | 2007 |
| Expatriate Advisory Services Limited | Financial services | 1978 |
| EY UP ME Duck Composites Ltd | Construction | 2024 |
| Eyre & Elliston Limited | Wholesale & retail | 1940 |
| Eyres 1984 Limited | | 1984 |
| F.A.B Life Limited | Other services | 2006 |
| Fabric Design (UK) Limited | Wholesale & retail | 2002 |
| Face to Face Financial Solutions Limited | Financial services | 2003 |
| Fairinca Limited | | 1985 |
| Family Mediation Forum Limited | Health & social care | 2001 |
| Feed Industry Link Limited | Professional & scientific | 2004 |
| Field Consulting Services Limited | Information & communication | 2005 |
| Fifteen TEN Consulting Limited | Extraterritorial | 2019 |
| Finance Advice Centre (Ilkeston) Limited | Other services | 2018 |
| Finch IT Solutions Ltd | Information & communication | 2004 |
| Fire Control UK Limited | Manufacturing | 1986 |
| Flamtek Limited | Manufacturing | 1999 |
| Flooring Solutions (Alfreton) Limited | Professional & scientific | 2001 |