| Stuart Harrison Windows Limited | Manufacturing | 2003 |
| Stuart Mason Limited | Wholesale & retail | 2019 |
| Stuart Mobility Limited | Wholesale & retail | 2015 |
| Stuart Swindell Limited | Agriculture & fishing | 2017 |
| Stuart Warnock Physiotherapy Limited | Health & social care | 2012 |
| Stuart Wood Photography Limited | Professional & scientific | 2007 |
| Stuartsdouglas Limited | Real estate | 2024 |
| Student Clues Ltd | Education | 2021 |
| Studio 86 Dance Ltd | Education | 2026 |
| Studio and Then Some Ltd. | Information & communication | 2016 |
| Studio L Aesthetics Limited | Health & social care | 2018 |
| Studio Mafa Ltd | Professional & scientific | 2022 |
| Studio Magnetique Ltd | Professional & scientific | 2023 |
| Studio Mccabe Ltd | Professional & scientific | 2024 |
| Studio Muessig Ltd | Professional & scientific | 2022 |
| Studio Nineteen KH Ltd | Other services | 2020 |
| Studio NO74 Ltd | Professional & scientific | 2021 |
| Studio O'Garro Limited | Professional & scientific | 2016 |
| Studio Spiteri Ltd | Construction | 2022 |
| Studio Till Ltd | Information & communication | 2023 |
| Studio WIN Ltd | Professional & scientific | 2026 |
| Studio Wolter Navarro Ltd | Professional & scientific | 2015 |
| Stuluc Properties Limited | Households | 2025 |
| Stumes Ltd | Information & communication | 2009 |
| Stunning Cinemas Limited | Information & communication | 2015 |
| Stvga Private Ltd | Wholesale & retail | 2020 |
| Style Barbers Mickleover Limited | Other services | 2022 |
| Style Online Hub Limited | Wholesale & retail | 2025 |
| Styles Group Ltd | Financial services | 2021 |
| Styles Renovations Limited | Construction | 2023 |
| Styles Solutions Limited | Financial services | 2021 |
| Stylevilla Ltd | Wholesale & retail | 2025 |
| SU Enterprise Ltd | Wholesale & retail | 2025 |
| SUA Dental Ltd | Health & social care | 2023 |
| SUA Holdings Ltd | Financial services | 2023 |
| Subby Group Ltd | Information & communication | 2023 |
| Subby Holdings Ltd | Financial services | 2024 |
| Subby Ltd | Financial services | 2024 |
| Subcontractor Accomodation Solutions Ltd | Real estate | 2025 |
| Sublime Sicily Limited | Wholesale & retail | 2012 |
| Substantial Properties Limited | Construction | 2008 |
| Substores Derby Limited | Extraterritorial | 2023 |
| Substores Limited | Wholesale & retail | 2002 |
| Success Academy Ltd | Professional & scientific | 2012 |
| Success Driving Academy Ltd | Education | 2025 |
| Success Publishing Ltd | Education | 2022 |
| Successora Ltd | Construction | 2026 |
| Sucoon Cafe Ltd | Hospitality | 2026 |
| Sudbury Inns Limited | Hospitality | 2000 |
| Sudbury Stores Ltd | Wholesale & retail | 2009 |
| Sudden Kebab Studios Limited | Information & communication | 2024 |
| Sudex Ltd | Professional & scientific | 2025 |
| SUE Andor Consulting Ltd | Information & communication | 2011 |
| SUE Cawdron Consultancy Services Ltd | Administrative & support | 2012 |
| Sufyaan Latif Properties Ltd | Real estate | 2025 |
| Sugar & Saffron Ltd | Manufacturing | 2025 |
| Sugar and Spice Ltd | Hospitality | 2026 |
| Sugar Bricks Ltd | Real estate | 2025 |
| Sugar Loaf Cafe Limited | Hospitality | 2026 |
| Sugar Rush Dessertz Ltd | Manufacturing | 2024 |
| Sugarcanes Nursery Ltd | Education | 2011 |
| Suite Spaces Ltd | Real estate | 2018 |
| Sujen (Derby) Limited | Real estate | 1963 |
| Sukh & Sons Ltd | Transport & logistics | 2025 |
| Sukhaksh Virk Ltd | Transport & logistics | 2025 |
| Sukhi Aesthetics Limited | Real estate | 2024 |
| Sukhman Haulage Ltd | Mining & quarrying | 2019 |
| Sukhmani Enterprises Ltd | Real estate | 2018 |
| Sulkowski Engineering Ltd | Professional & scientific | 2023 |
| Sullyman Ltd | Hospitality | 2025 |
| Sultan Asset Ltd | Real estate | 2018 |
| Sultan Halal Meats Limited | Wholesale & retail | 2026 |
| Sultan Shayan Transport Ltd | Transport & logistics | 2026 |
| Sultan Tours Ltd | Other services | 2016 |
| Sum'It Advisory Limited | Professional & scientific | 2023 |
| Sumans Collection Limited | Wholesale & retail | 2026 |
| Summer Track Services Limited | Construction | 2018 |
| Summerscales Fitness Coaching Ltd | Health & social care | 2023 |
| Summit IT Management Limited | Wholesale & retail | 2015 |
| Summit Property Solutions Limited | Real estate | 2018 |
| Summit Retail & Travel Limited | Wholesale & retail | 2020 |
| Summit Three Ltd | Information & communication | 2026 |
| Sun Hall 168 Limited | Hospitality | 2026 |
| Sun Living Midland Limited | Professional & scientific | 2020 |
| Sundial Analysis Services Ltd | Administrative & support | 2017 |
| Sundial Style Limited | Wholesale & retail | 2007 |
| Sundrop Properties Ltd | Real estate | 2022 |
| Sunfish Services Limited | Administrative & support | 2003 |
| Sunhart Ltd | Construction | 2015 |
| Sunlight Duffield Management Company Limited | Households | 2015 |
| Sunlit Summit Ltd | Manufacturing | 2024 |
| Sunner Brothers Construction Ltd | Construction | 2021 |
| Sunny Garage Ltd | Wholesale & retail | 2026 |
| Sunnyfields Catering Ltd | Hospitality | 2025 |
| Sunnyhill Barbers Ltd | Other services | 2025 |
| Sunnyhill Day Nursery Limited | Health & social care | 2023 |
| Sunnyhill Garden Limited | Hospitality | 2024 |
| Sunrise Constructions Ltd | Construction | 2020 |
| Sunset (Eco) Ltd | Agriculture & fishing | 2021 |
| Sunset Care Services Limited | Health & social care | 2020 |