| Sunset Events Derby Ltd | Administrative & support | 2018 |
| Sunset Medical Services Limited | Health & social care | 2011 |
| Sunshine Aesthetics Ltd | Health & social care | 2023 |
| Sunshine G M Ltd | Other services | 2017 |
| Sunshine Support (Derby) CIC | Information & communication | 2019 |
| Suntree Limited | Financial services | 2012 |
| Suntronix Engineering Solutions Ltd | Professional & scientific | 2025 |
| Supa Support Limited | Professional & scientific | 2004 |
| Super Asia Food and Spices Ltd | Wholesale & retail | 2024 |
| Super Clean Hand Car Wash Limited | Administrative & support | 2025 |
| Super CT Ltd | Transport & logistics | 2024 |
| Super Ideas Marketing Limited | Professional & scientific | 2014 |
| Super Media Group Ltd | Information & communication | 2025 |
| Super Mega Global Corp Ltd | Information & communication | 2021 |
| Super Oshee Derby Limited | Wholesale & retail | 2025 |
| Super SAM Derby Limited | Wholesale & retail | 2014 |
| Super SAM XL Limited | Wholesale & retail | 2021 |
| Superc Ltd | Education | 2021 |
| Supergeneral Motors Ltd | Wholesale & retail | 2024 |
| Superior Spray UK Ltd | Construction | 2019 |
| Superior Tiling and Floor Finishes Limited | Construction | 2025 |
| Supersonic Property Development Company Limited | Real estate | 2016 |
| Supine X Dragon PIG Limited | Hospitality | 2025 |
| Supotto Ltd | Wholesale & retail | 2019 |
| Supply Teach Group Ltd | Administrative & support | 2023 |
| Support YOU Care Ltd | Health & social care | 2023 |
| Supported Tenancy Solutions Limited | Real estate | 2008 |
| Supreme Auto Expert Limited | Professional & scientific | 2025 |
| Supreme Scuk Ltd | Financial services | 2020 |
| Supreme Tees Limited | Wholesale & retail | 2024 |
| Supreme Trade Services Ltd | Wholesale & retail | 2025 |
| Suraxia Ltd | Information & communication | 2017 |
| Sure Investment Group Limited | Arts & recreation | 2025 |
| Sure Snag 360 Surveys Limited | Professional & scientific | 2025 |
| Surefire Property Group Ltd | Real estate | 2022 |
| Surepulse Medical Limited | Manufacturing | 2012 |
| Surescreen Diagnostics Limited | Health & social care | 1996 |
| Surescreen Holdings (2022) Limited | Professional & scientific | 2022 |
| Surescreen Holdings Limited | Professional & scientific | 2014 |
| Surescreen Life Sciences Limited | Professional & scientific | 2002 |
| Surescreen Scientifics Limited | Professional & scientific | 2014 |
| Sureway Labs Ltd | Information & communication | 2025 |
| Surgite Properties Ltd | Real estate | 2021 |
| Surinder and HARMINDER100 Ltd | Real estate | 2024 |
| Surtal Arts Ltd | Arts & recreation | 2005 |
| Survey Talk Limited | Extraterritorial | 2002 |
| Susanna Samson Print Design Limited | Wholesale & retail | 1999 |
| Suskony Ltd | Manufacturing | 2017 |
| Sussex Peak Ltd | Real estate | 2024 |
| Sustain & Shine Limited | Hospitality | 2025 |
| Sustain Marketing Limited | Professional & scientific | 2012 |
| Sustainable Computers Ltd | Information & communication | 2012 |
| Sustainable Control Systems Limited | Energy | 1999 |
| Sustainable Power Design Solutions Ltd | Professional & scientific | 2024 |
| Sustainable Sailing Ltd | Manufacturing | 2021 |
| Sutton Johal Building Services Ltd | Construction | 2008 |
| Sutton Turner Houses | Health & social care | 2012 |
| Suya House Limited | Hospitality | 2023 |
| Suzanne's Chemistry Tuition Limited | Education | 2018 |
| SV Sales & Service Limited | Wholesale & retail | 2014 |
| SVA Property Ltd | Real estate | 2025 |
| Svarnam Properties Limited | Real estate | 2023 |
| SVC Property Limited | Professional & scientific | 2021 |
| SVR Retail PVT Ltd | Wholesale & retail | 2026 |
| Svyne Properties Limited | Real estate | 2025 |
| SW Electrical (Midlands) Ltd | Construction | 2004 |
| SW Express Ltd | Transport & logistics | 2025 |
| Swadk&A Limited | Hospitality | 2025 |
| Swahili Essence Ltd | Manufacturing | 2026 |
| Swallowtail Investments Limited | Real estate | 2022 |
| Swan Store Ltd | Wholesale & retail | 2023 |
| Swanbank Holdings Limited | Financial services | 2025 |
| Swanbank Properties Limited | Real estate | 2013 |
| Swanmore Properties Limited | Construction | 2022 |
| Swanson Bookkeeping Limited | Professional & scientific | 2025 |
| Swansons Transformations Ltd | Construction | 2022 |
| Swaran Parkash Ltd. | Hospitality | 2014 |
| Swarkestone Road Kennels Ltd | Agriculture & fishing | 2024 |
| Swed Holdings Ltd | Hospitality | 2024 |
| Sweeney's Barber Shop Ltd | Other services | 2016 |
| Sweet Factory Derby Limited | Wholesale & retail | 2026 |
| Sweet Sins Ltd | Hospitality | 2021 |
| Sweetgrass Beers Ltd | Professional & scientific | 2025 |
| Sweetgrass Pubs Ltd | Hospitality | 2024 |
| Swerve (UK) Ltd | Arts & recreation | 2010 |
| Swfa Ltd | Financial services | 2012 |
| SWG Flooring Limited | Construction | 1998 |
| Swift Derby Repairs Limited | Wholesale & retail | 2025 |
| Swift Engineering Services (Derby) Limited | Manufacturing | 1993 |
| Swift FIX Ltd | Other services | 2007 |
| Swift Logistics Derby Limited | Transport & logistics | 2025 |
| Swift Midland Ltd | Transport & logistics | 2022 |
| Swift React Limited | Professional & scientific | 2015 |
| Swift Web Creations Ltd | Information & communication | 2010 |
| Swifts (Derby) Limited | Wholesale & retail | 2004 |
| Swifts Homes Ltd | Real estate | 2015 |
| Swiftscape Ltd | Construction | 2017 |
| Swifty Inns Limited | Hospitality | 2026 |
| Swinco Commercial & Domestic Cleaning Limited | Administrative & support | 2024 |
| Swinger Car Valet Ltd | Administrative & support | 2022 |