| Shakir's Fashion Designer Ltd | Wholesale & retail | 2025 |
| Shakthi Design Solutions Limited | Administrative & support | 2011 |
| Shakti Academy Ltd | Education | 2017 |
| Shallbay Limited | Wholesale & retail | 2025 |
| Shama Parveen Limited | Health & social care | 2014 |
| Shamim Rashid Consultancy Limited | Professional & scientific | 2020 |
| Shanan & Lalli Derby Ltd | Real estate | 2024 |
| Shand Limited | Information & communication | 2011 |
| Shanley Booth Theatre School Limited | Arts & recreation | 2007 |
| Shanzay Khan International Ltd | Transport & logistics | 2024 |
| Shapcotts Holdings Limited | Financial services | 2015 |
| Shara Real Estate Ltd | Real estate | 2025 |
| Shardlow Crystal Clean Ltd | Administrative & support | 2025 |
| Shardlow Developments Limited | Construction | 2014 |
| Shardlow Group Ltd | Financial services | 2017 |
| Shardlow Hall Private Day Nursery Ltd | Health & social care | 2012 |
| Shardlow Mini Market Ltd | Wholesale & retail | 2023 |
| Shardlow Vending Limited | Administrative & support | 2001 |
| Share Cycle Derby CIC | Administrative & support | 2025 |
| Shareshill Renewables Limited | Energy | 2024 |
| Sharif Home Maintenance Ltd | Construction | 2013 |
| Sharing in Growth UK Limited | Professional & scientific | 2012 |
| Shark (Midlands) Ltd | Transport & logistics | 2016 |
| Sharky's Swimmers Limited | Education | 2012 |
| Sharma Brothers Ltd | Transport & logistics | 2024 |
| Sharma Crown Prints Ltd | Manufacturing | 2026 |
| Sharmarg Limited | Professional & scientific | 2006 |
| Sharmas Old Delhi Taste Ltd | Hospitality | 2025 |
| Sharoona Limited | Wholesale & retail | 2025 |
| Sharp Accounts Limited | Professional & scientific | 2010 |
| Sharp Edge Engineering Consultancy Ltd | Professional & scientific | 2023 |
| Sharpley Startin Wright Limited | Real estate | 2019 |
| Sharpy Productions Ltd | Arts & recreation | 2024 |
| Shaukmann Investments Ltd | Real estate | 2021 |
| Shaun Hall Ltd | Manufacturing | 2018 |
| Shava Autos Ltd | Transport & logistics | 2024 |
| Shava Tribe Ltd | Health & social care | 2019 |
| Shaw Green Technology LLP | | 2010 |
| Shaw Group Developments Limited | Real estate | 2022 |
| Shawarma Express Habibi Ltd | Hospitality | 2023 |
| Shawpak US Holdings Limited | Professional & scientific | 2019 |
| Shawrma 4 YOU Ltd | Hospitality | 2019 |
| Shaws Heating Ltd | Construction | 2018 |
| Shawsoft Ltd | Information & communication | 2017 |
| Shawty's Ltd | Hospitality | 2026 |
| Shaz (Derby) Ltd | Hospitality | 2023 |
| Sheadar Hand Car Wash Ltd | Other services | 2020 |
| Shear Capital Limited | Hospitality | 2020 |
| Sheblooms Limited | Wholesale & retail | 2024 |
| Sheep Seekers International CIC | Administrative & support | 2024 |
| Sheeth Adam Cars Ltd | Wholesale & retail | 2024 |
| Sheffield Women's AID | Health & social care | 2010 |
| Shekways Ltd | Wholesale & retail | 2025 |
| Sheldon Electrical Engineers and Contractors Ltd | Construction | 2010 |
| Sheldon Flanders Financial Services Ltd | Financial services | 2011 |
| Sheldonbury Projects Ltd | Professional & scientific | 2019 |
| Shelton Macworth Limited | Construction | 2024 |
| Shepshed Dance Club Ltd | Education | 2017 |
| Sheraz & Co Builders Ltd | Construction | 2025 |
| Sherburn Cement Limited | Extraterritorial | 2015 |
| Sherburn Minerals Limited | Extraterritorial | 1972 |
| Sherburn Sand Company Limited | Extraterritorial | 1984 |
| Sherburn Stone Company Limited | Extraterritorial | 1967 |
| Shergill Industries Ltd | Financial services | 2025 |
| Shergill Transport Limited | Transport & logistics | 2015 |
| Shergills Real Estate Ltd | Real estate | 2025 |
| Sherlock's House Ltd | Hospitality | 2022 |
| Sherock Holdings Limited | Real estate | 2018 |
| Sherwood Aggregates Limited | Extraterritorial | 2018 |
| Sherwood Commercial Lettings Limited | Real estate | 2020 |
| Sherwood Croft (Thorpe Willoughby) Management Company Limited | Households | 2017 |
| Sherwood Distribution & Storage Limited | Extraterritorial | 2018 |
| Sherwood Enterprises V Ltd | Real estate | 2018 |
| Sherwood Housing Limited | Real estate | 2016 |
| Sherwood Logistics Limited | Extraterritorial | 2018 |
| Sherwood Signs and Vehicle Livery Limited | Extraterritorial | 2020 |
| SHG Derby Limited | Financial services | 2026 |
| SHH 101 LLP | | 2013 |
| SHH102 LLP | | 2018 |
| Shield Air Ventilation Ltd | Energy | 2016 |
| Shield Financial Services Limited | Financial services | 2015 |
| Shield UK Events Ltd | Administrative & support | 2013 |
| Shields & Shields Limited | Wholesale & retail | 2026 |
| Shieldscare Urgency Ltd | Health & social care | 2026 |
| Shiftsquad Limited | Administrative & support | 2025 |
| Shilgozon Empire Ltd | Professional & scientific | 2024 |
| Shillcock Construction Limited | Construction | 2026 |
| Shiloh Africana Limited | Wholesale & retail | 2024 |
| Shiloh Custom Designs Ltd | Manufacturing | 2021 |
| Shiloh Faith Ministries International Limited | Other services | 2006 |
| Shiloh Healthcare Services Ltd | Health & social care | 2019 |
| Shine Accountancy Services Ltd | Professional & scientific | 2018 |
| Shine Health Care Solutions Ltd | Administrative & support | 2020 |
| Shine Mindcare Ltd | Health & social care | 2021 |
| Shiney Hand Car Wash Ltd | Administrative & support | 2024 |
| Shinning Light Healthcare Ltd | Public administration | 2024 |
| Shinwari Karahi House Derby Ltd | Hospitality | 2023 |
| Shiny Brewing Company Ltd | Manufacturing | 2012 |
| Ship Courier Limited | Transport & logistics | 2026 |
| Shipley Construction Ltd | Construction | 2014 |