| Shipley Repair Centre Ltd | Wholesale & retail | 2026 |
| Shipmate Systems Limited | Information & communication | 2014 |
| Shiptons Recovery Services Limited | Wholesale & retail | 2012 |
| Shira Management Limited | Professional & scientific | 2017 |
| Shires Grove (Boston Spa) Management Company Limited | Households | 2017 |
| Shisha BAE Ltd | Wholesale & retail | 2024 |
| Shiv Foods Limited | Hospitality | 2025 |
| Shivani Limited | Real estate | 2020 |
| SHK Enterprises Ltd | Hospitality | 2024 |
| SHL 2012 Limited | Professional & scientific | 2022 |
| SHL Derby Limited | Transport & logistics | 2023 |
| SHM Housing Ltd | Real estate | 2025 |
| Shoe Closet Leicester Limited | Other services | 2019 |
| Shone Building Holdings Limited | Extraterritorial | 2019 |
| Shone Building Limited | Construction | 1984 |
| Shonhai Girl Ltd | Health & social care | 2023 |
| Shooting Group Ltd | Arts & recreation | 2018 |
| Shop Chase Ltd | Wholesale & retail | 2025 |
| Shop for an Agent Ltd | Information & communication | 2013 |
| Shop Secure Limited | Wholesale & retail | 2017 |
| Shop Smartly Online Ltd | Wholesale & retail | 2025 |
| Shop to Door Limited | Wholesale & retail | 2025 |
| Shopmatik Ltd | Wholesale & retail | 2026 |
| Shoponlineb Ltd | Wholesale & retail | 2026 |
| Shoppy Zone Ltd | Wholesale & retail | 2024 |
| Shore Group Holdings Ltd | Financial services | 2021 |
| Shoreland Park (Hadston) Management Company Limited | Households | 2017 |
| Shortfin Property Group Ltd | Real estate | 2024 |
| Shortify Social Ltd | Professional & scientific | 2023 |
| Shorttime Ltd | Administrative & support | 2024 |
| Show & Glow Valeting Centre Ltd | Other services | 2021 |
| Show and Event Security Services Ltd | Arts & recreation | 2006 |
| Show UP Media Ltd | Information & communication | 2026 |
| Showcase Shutters Limited | Wholesale & retail | 2017 |
| Shrb PB Limited | Construction | 2025 |
| Shree Hari Logistics Ltd | Transport & logistics | 2026 |
| Shsj Transport Ltd | Transport & logistics | 2025 |
| Shuaib Holdings Limited | Health & social care | 2025 |
| Shucksmith Business Analysis Services Ltd | Information & communication | 2011 |
| Shuff Propco Limited | Real estate | 2020 |
| SHUKARANA2025PVT Limited | Hospitality | 2024 |
| Shumbaress Caring Hands Ltd | Health & social care | 2023 |
| Shunns IT Solutions Ltd | Information & communication | 2023 |
| Shuriken Poultry Meat Ltd | Manufacturing | 2023 |
| Shurrelle Ltd | Wholesale & retail | 2018 |
| Shut Your COB Limited | Hospitality | 2024 |
| Shuttersmith Limited | Other services | 2013 |
| Shwetara Designs Limited | Construction | 2024 |
| SHY Penguin Studios Ltd | Information & communication | 2025 |
| Shycare Ltd | Wholesale & retail | 2025 |
| Shyshark Capital Management Ltd | Real estate | 2024 |
| SI Investments LLP | | 2025 |
| Sial Justice Lawyers Ltd | Professional & scientific | 2024 |
| Sian Soor Ltd | Health & social care | 2014 |
| Sibbalds Financial Services Limited | Financial services | 2012 |
| Sibbalds Ltd | Professional & scientific | 2003 |
| Sibby Limited | Health & social care | 2016 |
| Sibieta Economics of Education Ltd | Education | 2018 |
| Sica Design Limited | Professional & scientific | 2014 |
| Siddiqui Education Ltd | Wholesale & retail | 2018 |
| Siddiqui Ents Ltd | Administrative & support | 2017 |
| Siddo Design Consultants Ltd | Professional & scientific | 2011 |
| Sideshow Soundz Ltd | Information & communication | 2025 |
| Sidewaysderbycomps Ltd | Wholesale & retail | 2026 |
| Sidhu Civils Limited | Construction | 2013 |
| Sidhu EFS Properties Limited | Real estate | 2025 |
| Sidhu Group Holdings Ltd | Financial services | 2026 |
| Sidr Properties Limited | Construction | 2005 |
| Sieben Rubber Industries Ltd | Water & waste | 2014 |
| Siecon Technologies Limited | Information & communication | 2012 |
| Sierra Delta Barroon Limited | Real estate | 2026 |
| Sierra Delta Projects Ltd | Real estate | 2023 |
| Sierra Sport Ltd | Wholesale & retail | 2026 |
| Sigma 032023 Limited | Financial services | 2023 |
| Sigma Architects Limited | Professional & scientific | 2021 |
| Sigma Electrical Export UK Ltd | Wholesale & retail | 2011 |
| Sigma Horse Properties Ltd | Real estate | 2016 |
| Sign Design (Derby) Ltd | Professional & scientific | 2012 |
| Sign Masters Limited | Manufacturing | 2021 |
| Signa Research Group Limited | Information & communication | 2020 |
| Signal Subcontractors Limited | Construction | 2008 |
| Signalco Limited | Administrative & support | 2020 |
| Signalsync Ltd | Financial services | 2025 |
| Signature Building Support Services Ltd | Other services | 2019 |
| Signature Fastfood Limited | Hospitality | 2026 |
| Signature Memories Ltd | Hospitality | 2025 |
| Signed Performance in Theatre | Arts & recreation | 1994 |
| Signet Solutions Limited | Professional & scientific | 1996 |
| Signwell Ltd | Professional & scientific | 2023 |
| Signy Ltd | Real estate | 2020 |
| Sigquality Ltd | Information & communication | 2026 |
| Silent Voice Limited | Manufacturing | 2022 |
| Silk Equity Limited | Real estate | 2023 |
| Silk FS Limited | Financial services | 2013 |
| Silk Mill Holdings Ltd | Financial services | 2024 |
| Silk Mill Maintenance Ltd | Construction | 2024 |
| Silk Mill Properties Ltd | Real estate | 2023 |
| Silkmillderby Ltd | Hospitality | 2022 |
| Sillah Cleaning Limited | Administrative & support | 2025 |
| Sillah Holdings Limited | Financial services | 2025 |