| Sensational Group Ltd | Financial services | 2025 |
| Sensational Properties Ltd | Real estate | 2024 |
| Sensiway Care Services Ltd | Health & social care | 2020 |
| Sensiway Ltd | Manufacturing | 2025 |
| Sensor Alarms Ltd | Administrative & support | 2007 |
| Sensori Aesthetics Ltd | Health & social care | 2022 |
| Sentiment Care Ltd | Health & social care | 2011 |
| Sentimex Care Limited | Health & social care | 2020 |
| Sentral East Midlands Properties Ltd | Real estate | 2021 |
| Sentral Investments Ltd | Real estate | 2019 |
| Sentricare East Mids Limited | Health & social care | 2005 |
| Sentriq Limited | Professional & scientific | 2022 |
| Sepia (Eco) Ltd | Agriculture & fishing | 2021 |
| Sepiaeb Limited | Administrative & support | 2005 |
| Seqesta Limited | Professional & scientific | 2016 |
| SER Plumbing Limited | Construction | 2002 |
| Seraphin Software Limited | Information & communication | 2006 |
| Serelle Gems Ltd | Wholesale & retail | 2026 |
| Serendipity Drinks Ltd | Hospitality | 2019 |
| Serene Homes Ltd | Real estate | 2017 |
| Serene Place CIC | Hospitality | 2025 |
| Serene Solicitors Ltd | Professional & scientific | 2025 |
| Serenity Bathrooms (Derby) Limited | Construction | 2017 |
| Serenity Midland INT Ltd | Real estate | 2025 |
| Serenity Renovations Limited | Construction | 2025 |
| Serg Camper Limited | Wholesale & retail | 2024 |
| Serious Sports Technology Limited | Information & communication | 2014 |
| Serious Taverns Trading Limited | Hospitality | 2019 |
| Serter Investment Ltd | Real estate | 2025 |
| Session Bars Limited | Hospitality | 2022 |
| Session Shots Ltd | Wholesale & retail | 2021 |
| Session Studios Ltd | Other services | 2020 |
| Sestri Ltd | Other services | 2019 |
| Setak Limited | Wholesale & retail | 2019 |
| Setec Group Limited | Financial services | 2017 |
| Setec Ltd | Professional & scientific | 2012 |
| Setec Property Limited | Hospitality | 2013 |
| Setpoint Tennis Coaching Ltd | Arts & recreation | 2024 |
| SETRA360 Limited | Transport & logistics | 2025 |
| Sets Properties Limited | Real estate | 2024 |
| Settlement Finance Limited | Financial services | 2016 |
| SEV Motor Company Limited | Wholesale & retail | 2023 |
| SEV Properties Limited | Real estate | 2004 |
| Sevali Care Ltd | Health & social care | 2024 |
| Seven (Derby) Limited | Hospitality | 2011 |
| Seven Forever Limited | Real estate | 2026 |
| Seven Hospitality Group Limited | Financial services | 2024 |
| Seven Tastes Sinfin Ltd | Hospitality | 2024 |
| Seven-Fifty Motor Club Limited(The) | Arts & recreation | 1955 |
| Sevens and Twelves Limited | Wholesale & retail | 2021 |
| Severn Sands (Holdings) Limited | Professional & scientific | 1996 |
| Severn Sands Limited | Mining & quarrying | 1982 |
| Sevra Ltd | Wholesale & retail | 2008 |
| SEW Trading Limited | Manufacturing | 2022 |
| Sexy Whales Homes Ltd | Real estate | 2022 |
| Seyi Israel Music Ltd | Information & communication | 2026 |
| Seyihq Limited | Information & communication | 2026 |
| Seymore Partnership Limited | Other services | 2012 |
| Seymour (2001 Management) Limited | Households | 2001 |
| SF (Derby) Ltd | Real estate | 2021 |
| SF Autos Ltd | Wholesale & retail | 2024 |
| SF Createsx Limited | Information & communication | 2021 |
| SF Decorating & Property Maintenance Ltd | Construction | 2021 |
| SFK Car Rental Ltd | Administrative & support | 2024 |
| Sfnisar Limited | Transport & logistics | 2021 |
| SFY Investments Ltd | Wholesale & retail | 2022 |
| SG 4 Limited | Real estate | 2026 |
| SG Advisory Services Ltd | Professional & scientific | 2020 |
| SG and Co Services Limited | Wholesale & retail | 2015 |
| SG COX Consulting Ltd | Information & communication | 2018 |
| Sgab Ltd | Construction | 2025 |
| SGB Contracting Services Limited | Manufacturing | 2017 |
| SGB Rail Services Ltd | Professional & scientific | 2022 |
| SGK Commercial Services Limited | Professional & scientific | 2024 |
| SGL Lets Limited | Real estate | 2025 |
| Sgleec Ltd | Financial services | 2023 |
| SGM Transport Limited | Transport & logistics | 2023 |
| SGP Property Limited | Real estate | 2018 |
| SGS Plastering & Rendering Wall Systems Ltd | Construction | 2026 |
| SH & MB Holdings Limited | Financial services | 2021 |
| SH Collections Accrington Ltd | Administrative & support | 2022 |
| SH Retail Limited | Wholesale & retail | 2022 |
| Shaan Logistics Limited | Transport & logistics | 2024 |
| Shabnams Healthcare Limited | Health & social care | 2023 |
| Shadow 1 Airsoft Ltd | Wholesale & retail | 2024 |
| Shadowfocus Consultancy Limited | Information & communication | 2014 |
| Shadytransport Ltd | Wholesale & retail | 2020 |
| Shaftesbury Construction Services Limited | Professional & scientific | 2020 |
| Shaftesbury Fixings Limited | Wholesale & retail | 2007 |
| Shah Building & Plumbing Services Ltd | Real estate | 2025 |
| Shah Foods Derby Ltd | Wholesale & retail | 2025 |
| Shahab Enterprise Limited | Health & social care | 2023 |
| Shaheen Security Ltd | Administrative & support | 2023 |
| Shaheen Security Services Ltd | Education | 2018 |
| Shahid Halal Poultry Ltd | Agriculture & fishing | 2013 |
| Shajjeee Holdings Ltd | Financial services | 2025 |
| Shak Kebabs Limited | Hospitality | 2021 |
| Shakin' IT Holdings Ltd | Wholesale & retail | 2019 |
| Shakin` IT Limited | Wholesale & retail | 2007 |
| Shakir AUS Marketing Limited | Wholesale & retail | 2025 |