| Secbee Limited | Information & communication | 2024 |
| Second Wind Goods Ltd | Wholesale & retail | 2025 |
| Secret Fruit Community Limited | Wholesale & retail | 2024 |
| Secrets Boutique Salon Ltd | Other services | 2011 |
| Secrets Hair Company Ltd | Other services | 2011 |
| Seear Investments Ltd | Financial services | 2019 |
| Senaris Ltd | Wholesale & retail | 2021 |
| Sensotemp Limited | Manufacturing | 2006 |
| Serafino Limited | Wholesale & retail | 2016 |
| Serj Construction Ltd | Construction | 2022 |
| Shabden Leisure Limited | Arts & recreation | 1994 |
| Shandong Wanda Boto Tyre Co., Limited | Professional & scientific | 2012 |
| Shane Mcandrew Films Ltd | Information & communication | 2023 |
| Shanghai Hualin Co., Limited | Professional & scientific | 2014 |
| Shanghai Newsky Industry Co., Ltd | Professional & scientific | 2008 |
| Shaormania Ltd | Hospitality | 2026 |
| Sharkroom Productions Ltd | Information & communication | 2025 |
| Sharpclad Ltd | Construction | 2022 |
| SHE Makes a Difference Ltd | Administrative & support | 2023 |
| Sheerclass Computing Limited | Information & communication | 2009 |
| Sheffield Railwayana Auctions Limited | Wholesale & retail | 2005 |
| Shemp Ltd | Wholesale & retail | 2023 |
| Shenzhen Orangehome Housewares Co., Ltd | Professional & scientific | 2006 |
| Shire Forestry and Fencing Limited | Agriculture & fishing | 2019 |
| Shire Rural Supplies Limited | Agriculture & fishing | 2022 |
| Shosoccer Football Coaching Limited | Education | 2023 |
| Shreeji Constructions Ltd | Construction | 2026 |
| Sibley Coleman Ltd | Wholesale & retail | 2025 |
| Siebtechnik Tema Ltd | Wholesale & retail | 1961 |
| Sigma Engineering Systems Limited | Manufacturing | 2023 |
| Signcraft (Doncaster) Limited | Real estate | 2001 |
| Silentstreets Ltd | Wholesale & retail | 2025 |
| Silk Events Limited | Financial services | 2017 |
| Silver Propeller Consulting Limited | Information & communication | 2010 |
| Silvestri Investments Limited | Real estate | 2023 |
| Silvestri Properties Limited | Real estate | 2019 |
| Silvmar Ltd | Transport & logistics | 2018 |
| Simber Properties Ltd | Real estate | 2025 |
| Simply Conveyancing Panel Management Limited | Administrative & support | 2009 |
| Simply Conveyancing Property Lawyers (East) Ltd | Professional & scientific | 2005 |
| Simply Conveyancing Property Lawyers Limited | Professional & scientific | 2009 |
| Simply Green Energy Services Limited | Administrative & support | 2010 |
| Singlepoint Calls Limited | Administrative & support | 2022 |
| Sirs Consultancy Ltd | Administrative & support | 2011 |
| Sivas Food Limited | Hospitality | 2020 |
| SJG Enterprises Ltd | Real estate | 2026 |
| SK Trans Ltd | Extraterritorial | 2011 |
| SK13 Trade Limited | Wholesale & retail | 2025 |
| Skillsedge Limited | Information & communication | 2000 |
| Skin & Hair Rejuvenation Medical Aesthetics Ltd | Other services | 2026 |
| Skylounge Limited | Information & communication | 2003 |
| Slam Dog Ltd | Wholesale & retail | 2015 |
| Slam Dunk IT Limited | Information & communication | 2011 |
| SLB Consulting Ltd | Professional & scientific | 2020 |
| Slik Media Limited | Professional & scientific | 2012 |
| Slim Racing Ltd | Arts & recreation | 2009 |
| Slipstream Turbine Pools Limited | Construction | 2019 |
| Smart Environmental Solutions Limited | Construction | 2012 |
| Smeng Ltd | Arts & recreation | 2017 |
| Smith Foster Limited | Professional & scientific | 2000 |
| Smithair Limited | Arts & recreation | 1996 |
| Smithbrook Construction Ltd | Construction | 2021 |
| Smrs Properties Ltd | Real estate | 2026 |
| Smythe’S Automotive Ltd | Wholesale & retail | 2021 |
| SN Logistik Ltd | Transport & logistics | 2024 |
| Snap Galleries Limited | Wholesale & retail | 2003 |
| SND TRANSPORT7 Limited | Transport & logistics | 2017 |
| Sned Property Holdings Limited | Financial services | 2022 |
| Snedker & Smith Developments Ltd | Construction | 2018 |
| Snowcard Insurance Services Limited | Financial services | 1990 |
| Snowcard Travel Services Limited | Administrative & support | 2000 |
| Soapna Co., Ltd | Professional & scientific | 2021 |
| Sockits Ltd | Wholesale & retail | 2025 |
| Sojo Investments Ltd | Financial services | 2025 |
| Solarfix Limited | Construction | 2018 |
| Solden Hill House Limited | Health & social care | 1954 |
| Solid Base Construction Materials Training & Consultancy Ltd | Construction | 2025 |
| Soma Hawk Ltd | Transport & logistics | 2023 |
| Sonar Design Limited | Professional & scientific | 2012 |
| Sonko Gileng Ltd | Health & social care | 2020 |
| South Northants Roofing Ltd. | Construction | 2002 |
| Southfield Arts Co Ltd | Arts & recreation | 2011 |
| SP & HB Limited | Real estate | 2010 |
| SP Ecomm Limited | Wholesale & retail | 2025 |
| Spa Farm Residents Limited | Households | 2024 |
| Sparker Engineering Ltd | Professional & scientific | 2024 |
| Sparkleclean (Midlands) Ltd | Administrative & support | 2021 |
| Sparks Warehouse Limited | Wholesale & retail | 2018 |
| Sparksage Tech Ltd | Professional & scientific | 2025 |
| Sparkt Limited | Information & communication | 2020 |
| Spec Hub Limited | Construction | 2024 |
| Specialist Car Valuations Limited | Professional & scientific | 2012 |
| Spectrum Foodservice Limited | Hospitality | 2011 |
| Spectrum Powder Coaters Limited | Manufacturing | 2014 |
| Spectrum Powder Holdings Limited | Financial services | 2025 |
| Spectrum Retailing Limited | Hospitality | 2025 |
| Speedsport Ltd | Wholesale & retail | 2000 |
| Spella Ltd | Real estate | 2023 |
| Spera Management (UK) Limited | Professional & scientific | 2024 |
| Spindicate Limited | Agriculture & fishing | 2010 |