| Regen Renewables Ltd | Construction | 2020 |
| Reinvent:Her CIC | Professional & scientific | 2025 |
| Reliance P/L Limited | Other services | 2014 |
| Religo Ltd | Transport & logistics | 2025 |
| Remedy Geotechnics Limited | Professional & scientific | 2014 |
| Renovation Trade Ltd | Construction | 2025 |
| Residential Structural Solutions Ltd | Professional & scientific | 2025 |
| Residual Barrier Technology Limited | Manufacturing | 2009 |
| Resinflow UK Ltd | Construction | 2025 |
| Resp Active Ltd | Wholesale & retail | 2016 |
| Retail Food Solutions Ltd | Hospitality | 1999 |
| Retail Zipline UK Ltd | Information & communication | 2023 |
| Rethinc Consulting | Professional & scientific | 2022 |
| REV Performance UK Ltd | Wholesale & retail | 2023 |
| Revive Auto Innovations (Manchester) Limited | Wholesale & retail | 2001 |
| Revo Developments Limited | Information & communication | 2003 |
| Revo Technik Limited | Wholesale & retail | 2002 |
| Revotread Ltd | Other services | 2025 |
| RFF Ltd | Wholesale & retail | 2025 |
| RG Electrical Solutions Limited | Manufacturing | 2015 |
| RGB Collective Ltd | Financial services | 2024 |
| RGS Health Limited | Health & social care | 2012 |
| Rich Metal International Co., Limited | Professional & scientific | 2005 |
| Richard Bull Electrical Ltd | Construction | 2006 |
| Rickett Architects Limited | Professional & scientific | 2003 |
| Ricoeurope Ltd | Wholesale & retail | 2008 |
| Ridehalo Limited | Manufacturing | 2025 |
| Ridley Marreco & Co Limited | Professional & scientific | 1998 |
| Ringer Development Co.Limited | Real estate | 1961 |
| Rival Boxing Gear UK Ltd | Wholesale & retail | 2016 |
| Riverbed Strategy Limited | Professional & scientific | 2022 |
| Riviera Electrical Services Ltd | Construction | 2015 |
| RJ Energy Solutions Limited | Administrative & support | 2018 |
| RJ Jackson Limited | Health & social care | 2019 |
| RJ Online Solutions Limited | Wholesale & retail | 2025 |
| RJS Financial Transformation Ltd | Professional & scientific | 2026 |
| RJS Premier Vine Ltd | Wholesale & retail | 2022 |
| Robert Rzepiela Transport Ltd | Transport & logistics | 2019 |
| Robinson Delivery Limited | Transport & logistics | 2024 |
| Rock Industries Europe Limited | Wholesale & retail | 2016 |
| Rock Roll Limited | Wholesale & retail | 2017 |
| Rockerhula Ltd | Arts & recreation | 2010 |
| Rocket Communications Limited | Information & communication | 2006 |
| ROE Warwick Ltd | Hospitality | 2026 |
| Rofin-Baasel UK Limited | Manufacturing | 1995 |
| Rogue Duck Ltd | Wholesale & retail | 2026 |
| Roll Over Protection Systems Ltd | Manufacturing | 2022 |
| Rollasons Solicitors LLP | | 2011 |
| Romix Transport Limited | Transport & logistics | 2013 |
| Romulux Limited | Administrative & support | 2017 |
| Rosa MAI Ltd | Financial services | 2025 |
| Rosetta Nail Daventry Limited | Other services | 2024 |
| Rosey's Vintage Limited | Wholesale & retail | 2022 |
| Roto UK Ltd | Wholesale & retail | 2020 |
| Roundhill Resources Limited | Information & communication | 2015 |
| RP Psychological Services Limited | Health & social care | 2024 |
| RROM30 Ltd | Professional & scientific | 2019 |
| RS Renovations and Maintenance Limited | Construction | 2025 |
| RTK Technologies Limited | Professional & scientific | 2003 |
| Rudkin Graphic Services Limited | Administrative & support | 1988 |
| Rudkin Systems Limited | Information & communication | 1999 |
| Rural Enterprises CIC | Education | 2011 |
| RW Solutions Ltd | Information & communication | 2018 |
| S-Rc CUP Ltd | Education | 2025 |
| S.J.F. Haulage Limited | Transport & logistics | 2003 |
| S.T.Challis Limited | Transport & logistics | 1944 |
| Safe 4 ME Limited | Professional & scientific | 2019 |
| Safe Place Psychology Ltd | Health & social care | 2022 |
| Safety Management Limited | Administrative & support | 1989 |
| Safety Partnership Ltd | Professional & scientific | 2003 |
| Safetynet Online Sentry Security Limited | Administrative & support | 2021 |
| Safir Ltd | Real estate | 2020 |
| Sage Safety and Training Limited | Professional & scientific | 2006 |
| Sahwira Market Place Ltd | Administrative & support | 2025 |
| Saint & Poet Upholstery Fabrics Ltd | Manufacturing | 2025 |
| Sais One Ltd | Wholesale & retail | 2022 |
| Sall's Catering Limited | Hospitality | 2014 |
| SAM Parker Paving Ltd | Construction | 2017 |
| Same Deutz-Fahr UK Ltd | Wholesale & retail | 1980 |
| Sana Construction Ltd | Construction | 2022 |
| Sandra Lloyd Ltd | Professional & scientific | 2024 |
| Sarah-Line Ltd | Transport & logistics | 2017 |
| Sarvjass Ltd | Real estate | 2024 |
| Sazai Property Investments Limited | Real estate | 2025 |
| SBB Construction Group Ltd | Construction | 2025 |
| Scarper Productions Limited | Administrative & support | 2005 |
| SCE Contracting Limited | Construction | 2014 |
| Schali Ltd | Extraterritorial | 2009 |
| SCL Abrasive Holdings Limited | Manufacturing | 2012 |
| SCL Property Holdings Limited | Wholesale & retail | 2008 |
| Scootfleet Group Limited | Administrative & support | 2016 |
| Scorpion Carpentry & Joinery Ltd | Manufacturing | 2024 |
| Scott Television & Media Limited | Information & communication | 2011 |
| Scott UV Ltd. | Wholesale & retail | 2012 |
| Scott's Landscapes Limited | Administrative & support | 2016 |
| Seahouses Investments Ltd | Financial services | 2025 |
| Seal Johncrane Group Co., Ltd | Manufacturing | 2020 |
| Searchstone Ltd | Administrative & support | 2022 |
| Seasons Snug Ltd | Real estate | 2025 |
| Sebastian Charles Mann Holdings Ltd | Real estate | 2023 |