| Spotty Dog Brewery Limited | Manufacturing | 2014 |
| Sprakes Motorsport Limited | Wholesale & retail | 2018 |
| Springdale Vintage & Collectables Ltd | Wholesale & retail | 2024 |
| SPS Europe Ltd | Administrative & support | 2008 |
| SR Trans Ltd | Extraterritorial | 2017 |
| Srjl Services Limited | Construction | 2018 |
| SRS Roofing Ltd | Construction | 2022 |
| ST Ipps Residents Limited | Households | 2026 |
| ST Ipps Residents Management Company Limited | Households | 2026 |
| ST LOO Limited | Households | 1991 |
| Stable Road Property Management Limited | Households | 2019 |
| Stageworks Theatre Company Ltd | Arts & recreation | 2026 |
| Stainless Feet & Castors Limited | Manufacturing | 2014 |
| Star CAB Daventry Ltd | Transport & logistics | 2026 |
| Starspot Limited | Manufacturing | 2005 |
| Statera Management Limited | Professional & scientific | 2026 |
| Statim Finance Limited | Extraterritorial | 2010 |
| Stationery on Screen Limited | Wholesale & retail | 2013 |
| Staverton Opco Limited | Hospitality | 2020 |
| STB Trans Ltd | Transport & logistics | 2018 |
| STD Logistics Ltd | Wholesale & retail | 2017 |
| Steam Traction World Limited | Manufacturing | 2008 |
| Stefan UK Midco Limited | Hospitality | 2022 |
| Stefan UK Propco Limited | Hospitality | 2022 |
| Steph Analytical Ltd | Professional & scientific | 2025 |
| Stericlean (UK) Limited | Water & waste | 2005 |
| Steve Tubb Fabrications Limited | Manufacturing | 1991 |
| Stone World UK Limited | Wholesale & retail | 2004 |
| Stonhills Property Ltd | Real estate | 2022 |
| Strada Contract Services Limited | Construction | 2017 |
| Strada Group Ltd | Real estate | 2016 |
| Strada Homes (Development) Limited | Real estate | 2017 |
| Strada Lettings Limited | Real estate | 2019 |
| Strand Boutique Ltd | Other services | 2005 |
| Stratafloor Ltd | Construction | 2025 |
| Stratos Performance Ltd | Professional & scientific | 2020 |
| Stress Free HR Ltd | Administrative & support | 2017 |
| Structural Panda Ltd | Information & communication | 2022 |
| Stuart Nichols Waste Disposal Limited | Water & waste | 2005 |
| Studio Vicary Limited | Information & communication | 2025 |
| Stunt Dogs & Animals Limited | Information & communication | 2016 |
| Subsidium Managed Solutions Limited | Information & communication | 2015 |
| Subsight Holdings Limited | Financial services | 2023 |
| Subsight Surveys Limited | Professional & scientific | 1994 |
| Suburban Environmental Services Limited | Administrative & support | 1999 |
| Suchy Enterprise Ltd | Transport & logistics | 2016 |
| Suero Studio Ltd | Information & communication | 2022 |
| Sugarswell Developments Ltd | Construction | 2017 |
| Sukra Limited | Financial services | 2012 |
| Sunny Wireless Limited | Other services | 2001 |
| Sunnydale Drive Ltd | Arts & recreation | 2021 |
| Sunora Holdings Ltd | Extraterritorial | 2014 |
| Superior IT Engineers Limited | Information & communication | 2010 |
| Superior Roofing Solutions Ltd | Construction | 2018 |
| Supita Limited | Transport & logistics | 2020 |
| Supreme Grilled Chicken Limited | Hospitality | 2022 |
| Supreme View Window Cleaning Ltd | Administrative & support | 2023 |
| Suretech Adhesive Tapes Limited | Wholesale & retail | 1998 |
| Sustainable Leather Foundation CIC | Administrative & support | 2020 |
| Swain Building & Maintenance Ltd | Construction | 2025 |
| Swaminarayan Properties Limited | Real estate | 2017 |
| Swan Bespoke Furniture Ltd | Manufacturing | 2015 |
| Swan Business Services Ltd | Professional & scientific | 2020 |
| Swan Power Ltd | Wholesale & retail | 2022 |
| SWB Motorsport Ltd | Arts & recreation | 2010 |
| Sweeney-Stockley&Co Ltd | Professional & scientific | 2023 |
| Swoosh Decor (Commercial) Ltd | Construction | 2018 |
| Swynx Ltd | Professional & scientific | 2026 |
| Synergy Tyres (Midlands) Ltd | Water & waste | 2017 |
| Synthprincipal Ltd | Information & communication | 2024 |
| Sysmek Ag&Co GmbH Limited | Professional & scientific | 2014 |
| SZ & SZ Ltd | Transport & logistics | 2018 |
| Szabo 2018 Ltd | Extraterritorial | 2018 |
| T and C Engineers Ltd | Professional & scientific | 2010 |
| Tabeauty Ltd | Other services | 2025 |
| Tagove Limited | Information & communication | 2015 |
| Tail Tech Maintenance Ltd | Wholesale & retail | 2025 |
| Taiwan Chyuan Hsiang Holding Limited | Professional & scientific | 2013 |
| Talbot Homes Limited | Construction | 2014 |
| Tales From Atal Ltd | Information & communication | 2024 |
| Talk Electrics Limited | Construction | 2020 |
| Talltrees Property Limited | Real estate | 2018 |
| Tanpa Ltd | Agriculture & fishing | 2023 |
| Tanya 779 Limited | Information & communication | 2016 |
| Target Electrical Contractors Ltd | Construction | 2015 |
| Target Holdings (UK) Ltd | Wholesale & retail | 2007 |
| Taurus Recycling Solutions Ltd | Wholesale & retail | 2019 |
| Tavismode Limited | Water & waste | 1987 |
| Taylands Limited | Administrative & support | 2011 |
| Taymor Property Management Limited | Real estate | 2021 |
| TBK Pets Ltd | Wholesale & retail | 2025 |
| TBK UN Limited | Manufacturing | 2025 |
| Tdci Limited | Information & communication | 1993 |
| TEC Cooling Solutions Limited | Energy | 2018 |
| Tech Harbour LLP | | 2023 |
| Tech KRB Ltd | Information & communication | 2025 |
| TED Logistics Ltd | Transport & logistics | 2024 |
| Teksec Ltd | Administrative & support | 2013 |
| Temporary Works Solutions Ltd | Professional & scientific | 2024 |
| Teresa-Deli Ltd | Wholesale & retail | 2011 |