| Silky Styles Limited | Wholesale & retail | 2025 |
| Silvergate Consulting (Crewe) Limited | Professional & scientific | 2002 |
| Simbiatuu Enterprises Limited | Wholesale & retail | 2025 |
| Simon Bourne Limited | Agriculture & fishing | 2008 |
| Simon Clutton Homes Limited | Construction | 2006 |
| Simon Davies Limited | Agriculture & fishing | 2009 |
| Simon Wain Ltd | Information & communication | 2017 |
| Simpledetailing Ltd | Wholesale & retail | 2020 |
| Simpleserve Web Design Limited | Information & communication | 2017 |
| Simply Certified Ltd | Professional & scientific | 2025 |
| Simply Enterprises Limited | Wholesale & retail | 2015 |
| Simply Sorted Living Ltd | Other services | 2024 |
| Simson Catering Ltd | Wholesale & retail | 2024 |
| SIR Wash Limited | Wholesale & retail | 2024 |
| Sitech Contracting Ltd | Construction | 2008 |
| Sitwell Sofas Ltd | Wholesale & retail | 2025 |
| SIX Hills Developments Ltd | Real estate | 2020 |
| SJ Bespoke Clean Limited | Administrative & support | 2025 |
| SJ Project Management Limited | Construction | 2023 |
| SJ Solutions DPO Consultancy Limited | Professional & scientific | 2025 |
| SJA Media Holdings Ltd | Information & communication | 2025 |
| SJB Truck Design Ltd | Manufacturing | 2021 |
| SJC Lifestyle Limited | Financial services | 2019 |
| SJD Landscaping & Fencing Specialists Limited | Administrative & support | 2018 |
| SJM Nines Ltd | Transport & logistics | 2021 |
| SK BARBERCUT2 Ltd | Other services | 2025 |
| Skade Limited | Professional & scientific | 2018 |
| Skatey.Co.Uk Ltd | Manufacturing | 2014 |
| Skeffington Marine Ltd | Energy | 2011 |
| Skeffington Properties Limited | Real estate | 2016 |
| Skin Aesthetics by Wiola Limited | Other services | 2023 |
| Skinviva Holdings Ltd | Financial services | 2025 |
| Skoof Ltd | Information & communication | 2025 |
| Sksdr Ltd | Financial services | 2021 |
| Skye Aerial Arts Studio Ltd | Arts & recreation | 2026 |
| SL Global Ltd | Education | 2025 |
| SL LIN Limited | Hospitality | 2025 |
| Sleepeasy Serviced Accommodation Ltd | Real estate | 2016 |
| SLM Consultants Limited | Information & communication | 2009 |
| SLSERVICES4U Ltd | Manufacturing | 2019 |
| Slurrylink Holdings Ltd | Financial services | 2023 |
| Slurrylink Ltd | Wholesale & retail | 2023 |
| SM Barber Crewe Ltd | Other services | 2025 |
| SM Elite Ltd | Real estate | 2022 |
| Smart Start Preschool and Childcare Ltd | Health & social care | 2023 |
| Smart Step Consultancy Limited | Professional & scientific | 2019 |
| Smart Systems Group Limited | Information & communication | 2018 |
| Smartflow Cheshire Ltd | Construction | 2024 |
| Smarthouse Technology Limited | Administrative & support | 2006 |
| Smartoche Limited | Information & communication | 2025 |
| Smartone Limited | Wholesale & retail | 2024 |
| Smartvision Technologies Limited | Information & communication | 2023 |
| SME Joinery & Building Ltd | Construction | 2022 |
| Smile & Glow Studio Ltd | Other services | 2026 |
| Smiles to Come CIC | Education | 2025 |
| Smith & Coyle Properties Limited | Real estate | 2023 |
| Smith Booze Limited | Wholesale & retail | 2011 |
| Smith Jones Ltd | Real estate | 2025 |
| Smith Properties (Duquesa) Limited | Real estate | 2023 |
| Smiths Auto Cooling Services Limited | Wholesale & retail | 2014 |
| Smithys TCG Ltd | Wholesale & retail | 2025 |
| Smma Geniuses Ltd | Professional & scientific | 2024 |
| Smooth Stone Care and Education Limited | Health & social care | 2017 |
| SMS Squared Consultants Limited | Professional & scientific | 2006 |
| Snape Hall Barns Management Company Ltd | Real estate | 2019 |
| Snappy Lets Ltd | Real estate | 2023 |
| SNC PVT Ltd | Construction | 2022 |
| Sneakers Arena Limited | Wholesale & retail | 2017 |
| Sniffa Network Security Solutions Ltd | Information & communication | 2019 |
| Snowdon Developments Limited | Real estate | 2006 |
| Snowdrop Property Partners Ltd | Real estate | 2017 |
| SO Simple PM Ltd | Information & communication | 2018 |
| Social Pilgrim Ltd | Manufacturing | 2020 |
| Sockatyes Limited | Professional & scientific | 2015 |
| Software Efficiency Ltd | Information & communication | 2020 |
| Soh.Coh Limited | Professional & scientific | 2026 |
| Sokari Ltd | Wholesale & retail | 2026 |
| Solar Footprint Energy Ltd | Construction | 2026 |
| Solas Chapter III Limited | Professional & scientific | 2021 |
| Solitaire Insight Ltd | Professional & scientific | 2008 |
| Solstice Park Developments Limited | Construction | 2022 |
| Solutions GC Limited | Construction | 2025 |
| Solvo VIR Ltd | Administrative & support | 2012 |
| Soma Root Ltd | Wholesale & retail | 2024 |
| Sonata Plus Ltd | Information & communication | 2017 |
| Sonuu Developments Limited | Construction | 2019 |
| SOR Safety Limited | Public administration | 2026 |
| SOS Stoke on Trent Limited | Wholesale & retail | 2013 |
| Sottyman Group Logistics Ltd | Transport & logistics | 2018 |
| Sound Marquees Limited | Administrative & support | 2001 |
| Sound Minderz Limited | Wholesale & retail | 2025 |
| Soundbites Creative Ltd | Information & communication | 2019 |
| South & North Cheshire Chamber of Commerce & Industry Ltd | Administrative & support | 1993 |
| South Cheshire Briquettes Ltd | Manufacturing | 2022 |
| South Cheshire Carpentry Ltd | Construction | 2021 |
| South Cheshire Chamber Property Limited | Real estate | 1988 |
| South Cheshire Commercial Services Ltd | Financial services | 2012 |
| South Cheshire Development Agency Limited | Financial services | 2016 |
| South Cheshire Digital Limited | Information & communication | 2018 |
| South Cheshire Electrical Solutions Ltd | Construction | 2012 |