| SBP Group Holdings Limited | Financial services | 2025 |
| SC Mina Ltd | Transport & logistics | 2024 |
| SCA Mocks Limited | Education | 2026 |
| SCA Solar Limited | Construction | 2022 |
| SCALEXTRIC4SCHOOLS CIC | Education | 2025 |
| Scandinavian Energy Contractor Operations Limited | Professional & scientific | 2016 |
| Scarlatt Ltd | Information & communication | 2025 |
| Scarlatt Property Development Limited | Construction | 2025 |
| SCB Procurement Solutions Ltd | Administrative & support | 2016 |
| School Data Protection Officers Limited | Education | 2017 |
| Schosween 9 Limited | Construction | 2012 |
| Sci-Gall Fabrication Limited | Administrative & support | 2006 |
| Scott & Co. Landscaping & Groundworks Ltd | Administrative & support | 2025 |
| Scott Partnership Group Ltd | Financial services | 2022 |
| Scott Partnership Holdings Ltd. | Professional & scientific | 2007 |
| Scotts Tree Care Ltd | Other services | 2025 |
| Scrummatters Ltd | Information & communication | 2015 |
| SDC Construct Limited | Administrative & support | 2021 |
| SDH Autos Ltd | Wholesale & retail | 2015 |
| SDL17 Transport Ltd | Transport & logistics | 2022 |
| Seafoodhousecrewe Ltd | Hospitality | 2025 |
| Sean Mccabe (Financial Adviser) Limited | Financial services | 2006 |
| Secguard Ltd | Administrative & support | 2025 |
| Second Mouse Solutions Ltd | Professional & scientific | 2020 |
| Secure Tools for Working at Height Limited | Wholesale & retail | 2014 |
| Security Installation & Service (UK) Limited | Administrative & support | 2005 |
| SEE Global Limited | Information & communication | 2001 |
| Selby Rural & Co LLP | | 2022 |
| Selby Rural Holdings Limited | Financial services | 2026 |
| Selby Rural Limited | Real estate | 2026 |
| Selby Rural Property Limited | Construction | 2026 |
| Selbywoods Properties Limited | Real estate | 2017 |
| Seldominn Limited | Hospitality | 2025 |
| Select Choice Properties Limited | Real estate | 2025 |
| Self Defence With Clare Ltd | Arts & recreation | 2024 |
| Sellitbyai Ltd | Information & communication | 2026 |
| Sem-Jay Solutions Limited | Information & communication | 2024 |
| Senly Services Limited | Professional & scientific | 2017 |
| Senseware Limited | Wholesale & retail | 2023 |
| Sentech Consulting Ltd | Professional & scientific | 2022 |
| Senups Ltd | Financial services | 2024 |
| Sepa Auto Ltd | Wholesale & retail | 2023 |
| Sequentia Group Ltd | Professional & scientific | 2025 |
| Serco Trans Ltd | Transport & logistics | 2020 |
| Sercon Limited | Manufacturing | 2001 |
| Serenity RN Ltd | Health & social care | 2025 |
| Serenity Skin Limited | Other services | 2015 |
| Service My Stove Ltd | Administrative & support | 2025 |
| Servo Motors Ltd | Administrative & support | 2019 |
| SES Renewables Ltd | Construction | 2024 |
| SET Place Limited | Information & communication | 2019 |
| Sethhorizon Ltd | Wholesale & retail | 2022 |
| Seventytwo Football Ltd | Professional & scientific | 2024 |
| SEX Toys Limited | Wholesale & retail | 2023 |
| SF Production Ltd | Information & communication | 2018 |
| SG Developments (Nantwich) Ltd | Real estate | 2017 |
| SG Hair Solutions Limited | Other services | 2026 |
| SG Holdings Cheshire Limited | Professional & scientific | 2017 |
| SG Property (UK) Ltd | Real estate | 2011 |
| SG Property Holdings Ltd | Real estate | 2016 |
| SG Technical Consultancy Limited | Information & communication | 2016 |
| SG Travel Ltd | Transport & logistics | 2022 |
| SG World Limited | Manufacturing | 1997 |
| SGS Books Limited | Wholesale & retail | 2012 |
| SGW Payroll Limited | Administrative & support | 2007 |
| Shades 4 U Limited | Wholesale & retail | 2026 |
| Shakir Oyewole Ltd | Wholesale & retail | 2023 |
| Shaorma and More Ltd | Hospitality | 2025 |
| Shard Imaging Limited | Wholesale & retail | 2012 |
| Sharp Peak Associates Limited | Information & communication | 2019 |
| Sharpletter Limited | Information & communication | 1993 |
| SHD (Alfreton) Limited | Extraterritorial | 2018 |
| She's Scott This Limited | Information & communication | 2025 |
| Shearer & Co Ltd | Professional & scientific | 2014 |
| Sheldon & Sons Limited | Information & communication | 2006 |
| Sheldon Engineering Ltd | Manufacturing | 2024 |
| Shellcore Build Limited | Construction | 2018 |
| Sheppenhall Property Limited | Real estate | 2022 |
| Sherratt Eyecare Ltd | Wholesale & retail | 2019 |
| Sherwin Cattle Group Limited | Agriculture & fishing | 2025 |
| Sherwin Property Group Limited | Construction | 2025 |
| Sherworth Developments Limited | Real estate | 2016 |
| Sherworth Holdings Limited | Financial services | 2021 |
| Shijuflow Limited | Information & communication | 2026 |
| SHM Services Limited | Administrative & support | 2026 |
| Shop&Enjoy Ltd | Agriculture & fishing | 2025 |
| Show Business Interiors Limited | Construction | 2003 |
| SHOWCASE360 Ltd | Arts & recreation | 2018 |
| Shropshire Union Fly-Boat Restoration Society Limited | Education | 1990 |
| SHS Food Ltd | Hospitality | 2022 |
| SHW Developments Limited | Real estate | 2018 |
| SHW Events Limited | Administrative & support | 2009 |
| SHY Pictures Limited | Information & communication | 2018 |
| Sibaxo Ltd | Administrative & support | 2020 |
| Sicura Global Limited | Administrative & support | 2023 |
| Siddle Equine Service Limited | Professional & scientific | 2025 |
| Sidev Ltd | Professional & scientific | 2005 |
| SIG Commodities Consultancy Limited | Administrative & support | 2017 |
| Signature Underwriting Agency Ltd | Financial services | 2013 |
| Silkwood Communications Limited | Information & communication | 2013 |