| Route 151 TCG Ltd | Wholesale & retail | 2026 |
| Roxi Sold 2 YOU Ltd | Wholesale & retail | 2025 |
| Rozz D Ltd | Administrative & support | 2023 |
| RPS Enterprises Limited | Administrative & support | 2023 |
| RR Lifestyle Limited | Administrative & support | 2020 |
| RS Lifts-Elevator Rope Services Ltd | Professional & scientific | 2019 |
| RS SAN Ltd | Other services | 2024 |
| RS4 Roofing & Scaffolding Ltd | Construction | 2015 |
| RSD Social Care Limited | Health & social care | 2011 |
| RSW Transport & Logistics Ltd | Administrative & support | 2015 |
| Rubberlegs Ltd | Arts & recreation | 2014 |
| Rubin Coral Limited | Financial services | 2019 |
| Rudaw's Salon Crewe Ltd | Other services | 2023 |
| Rukan Supermarket Limited | Wholesale & retail | 2019 |
| Rumcyk Ltd | Transport & logistics | 2016 |
| Rushton Advisory Ltd | Professional & scientific | 2026 |
| Ruskin Road Management Company Limited | Real estate | 2006 |
| Russell & Partners (International Search) Limited | Administrative & support | 1995 |
| Russell & Partners Ltd | Administrative & support | 2006 |
| Rutter Retail Limited | Wholesale & retail | 2019 |
| RVM Repairs Limited | Wholesale & retail | 2022 |
| RW6 Properties Limited | Real estate | 2022 |
| RWB NS Consulting Limited | Professional & scientific | 2021 |
| RWH Contracting Limited | Transport & logistics | 2025 |
| RWL Accountancy Limited | Professional & scientific | 2019 |
| RWS Models Limited | Wholesale & retail | 2009 |
| Ryman Group Limited | Professional & scientific | 1992 |
| Ryman Limited | Wholesale & retail | 1995 |
| Ryness Solutions Limited | Information & communication | 2021 |
| S & D Properties (Staffs) Limited | Real estate | 2018 |
| S & K Cantonese Limited | Hospitality | 2022 |
| S & NJ Properties Ltd | Real estate | 2025 |
| S B Griffiths Driveways Limited | Construction | 2014 |
| S H a Holdings Limited | Financial services | 2017 |
| S I Repairs Limited | Manufacturing | 2002 |
| S J Cork Ltd. | Transport & logistics | 2017 |
| S J Moore Textiles Limited | Wholesale & retail | 2026 |
| S Jackson Investments Limited | Financial services | 2026 |
| S K Distribution Logistics Ltd | Transport & logistics | 2018 |
| S M Collins Ltd | Manufacturing | 2023 |
| S R Forsyth Limited | Professional & scientific | 2006 |
| S Rhodes Transport Consultancy Limited | Professional & scientific | 2025 |
| S Szogedi Limited | Professional & scientific | 2025 |
| S Young Autos Limited | Wholesale & retail | 2018 |
| S&G Fitness Unit Ltd | Education | 2025 |
| S&N Retails Ltd | Wholesale & retail | 2024 |
| S&O Hall Limited | Health & social care | 2015 |
| S&T Solutions Ltd | Construction | 2022 |
| S.Bebbington Enterprises Limited | Agriculture & fishing | 2016 |
| S.J Legal and Consultancy Ltd | Professional & scientific | 2018 |
| S.T.A.L.L.S (Cheshire) Limited | Agriculture & fishing | 2026 |
| S3 Communications Ltd | Information & communication | 2016 |
| SA Calvert Limited | Manufacturing | 2005 |
| SA Crewe Ltd | Hospitality | 2017 |
| SA Sauces Ltd | Manufacturing | 2014 |
| Sable Hire Limited | Administrative & support | 2018 |
| Sadaf Halal Market Limited | Wholesale & retail | 2024 |
| Sadler Scientific Ltd. | Professional & scientific | 2015 |
| Safe 365 UK Ltd | Professional & scientific | 2021 |
| Safe Drive Solutions Limited | Other services | 2023 |
| Safe Opportunities Ltd | Education | 2014 |
| Safety Squared Limited | Professional & scientific | 2023 |
| Safetynet Solutions Limited | Information & communication | 2000 |
| Saffron Technologies Limited | Wholesale & retail | 2012 |
| Saint Homes Investments Ltd | Real estate | 2026 |
| Sait Holdings Ltd | Real estate | 2024 |
| Sakura Services Limited | Professional & scientific | 2022 |
| Sala Group Ltd | Wholesale & retail | 2021 |
| Salon 6277 Limited | Other services | 2017 |
| Saltstone Partners Limited | Administrative & support | 2025 |
| Salus Consultants Limited | Professional & scientific | 2012 |
| Salway Ltd | Information & communication | 2021 |
| SAM & SON LKW Ltd | Transport & logistics | 2019 |
| Sammys European Express Services Limited | Transport & logistics | 2009 |
| Samscon Ltd | Other services | 2013 |
| Sandbach Commercials Limited | Wholesale & retail | 2021 |
| Sandevi Construction Ltd | Construction | 2026 |
| Sandexim Limited | Transport & logistics | 2016 |
| Sands Investments Limited | Professional & scientific | 2018 |
| Sandwichesdirect Limited | Hospitality | 2023 |
| Sandycroft Developments Limited | Real estate | 1991 |
| Sanitas Domus C.I.C. | Real estate | 2026 |
| Santosha Kennels Limited | Other services | 2007 |
| Sapereadvisory Limited | Professional & scientific | 2026 |
| Sarah Faulkner Lettings and Management Limited | Real estate | 2013 |
| Sarges Trading Limited | Wholesale & retail | 2024 |
| SAS Capital Solutions Limited | Administrative & support | 2025 |
| Sasha International Limited | Manufacturing | 2018 |
| Saunders Property & Developments Ltd | Real estate | 2025 |
| Save a Life Cheshire Ltd | Agriculture & fishing | 2018 |
| Savretail Ltd | Wholesale & retail | 2024 |
| Sawamat Limited | Wholesale & retail | 2020 |
| Saxnet Limited | Administrative & support | 2014 |
| Saxon Court Palmer Road (Management) Company Limited | Households | 2006 |
| Saxon Operations Executive Limited | Professional & scientific | 2016 |
| SAY Cheese Photo Ltd | Information & communication | 2024 |
| SB of W Limited | Other services | 2016 |
| SBI Holdings Ltd | Financial services | 2018 |
| Sbkfc Ltd | Arts & recreation | 2025 |
| Sbkp Mobility Ltd | Transport & logistics | 2026 |