| Crewe Denture Laboratory Limited | Health & social care | 2017 |
| Crewe Engineering Supplies Limited | Professional & scientific | 1982 |
| Crewe Events & Catrings Ltd | Hospitality | 2026 |
| Crewe Expert Bodyshop Ltd | Wholesale & retail | 2021 |
| Crewe Fast Food Limited | Hospitality | 2026 |
| Crewe FC (Commercial Operations) Limited | Arts & recreation | 2024 |
| Crewe FC (Competitive Sport) Limited | Arts & recreation | 2024 |
| Crewe Funeral Services Ltd | Other services | 2016 |
| Crewe Furnishings Outlet Ltd | Wholesale & retail | 2024 |
| Crewe Furniture Ltd | Wholesale & retail | 2023 |
| Crewe Golf Club Limited | Arts & recreation | 1965 |
| Crewe Hair and Skin Clinic Limited | Other services | 2017 |
| Crewe Home Style Ltd | Wholesale & retail | 2024 |
| Crewe Hotels Ltd | Hospitality | 2022 |
| Crewe HT Catering Ltd | Hospitality | 2026 |
| Crewe Match Angling Centre Limited | Wholesale & retail | 2009 |
| Crewe Mechanic Mobile Services Ltd | Professional & scientific | 2026 |
| Crewe Moonlite Ltd | Hospitality | 2026 |
| Crewe Pizza House Ltd | Hospitality | 2021 |
| Crewe Plumbing Limited | Construction | 2023 |
| Crewe Rail Limited | Administrative & support | 2010 |
| Crewe Takeaway Ltd | Hospitality | 2018 |
| CREWE-CW2 Ltd | Manufacturing | 2023 |
| CREWE-CW2 Tyres Ltd | Wholesale & retail | 2025 |
| Crewecreates CIC | Arts & recreation | 2023 |
| Criddle Electrical Services Limited | Construction | 2018 |
| Crimewatch Security (UK) LLP | | 2017 |
| Crisp Leaves Ltd | Extraterritorial | 2024 |
| Cristian Gioiello Ltd | Wholesale & retail | 2023 |
| Crit Happens Dice Ltd | Extraterritorial | 2024 |
| CRM Wise Ltd | Mining & quarrying | 2024 |
| Croco Professional Services Ltd | Professional & scientific | 2023 |
| Croft Construction (NW) Ltd | Construction | 2019 |
| Cross Fabrications Ltd | Manufacturing | 2014 |
| Crossover Festival Limited | Administrative & support | 2016 |
| Crown N&B Supply Limited | Other services | 2019 |
| Crown Pest Control Limited | Other services | 2022 |
| Crown Rail & Environmental Services Ltd | Other services | 2013 |
| Crown Securities (UK) Limited | Administrative & support | 2003 |
| Crownro Ltd | Hospitality | 2025 |
| Crue and Co Limited | Real estate | 2025 |
| Crusader Assistance Group Holdings Limited | Administrative & support | 2008 |
| Crusader Group Holdings Limited | Professional & scientific | 2006 |
| Crusader Uninsured Loss Recovery Service Limited | Financial services | 1994 |
| Crvcouriers Ltd | Transport & logistics | 2023 |
| Crypt Studios Ltd | Information & communication | 2024 |
| Crystal Clear EAR Care Ltd | Health & social care | 2023 |
| Csdi Structural Ltd | Other services | 2025 |
| CSL Enterprises LLP | | 2019 |
| CSL Gaming Ltd | Professional & scientific | 2022 |
| CSS20 Construction Site Service Ltd | Professional & scientific | 2020 |
| CT Breakdown Consulting Ltd | Transport & logistics | 2025 |
| Ctse Limited | Construction | 2010 |
| Cube Surveys Limited | Construction | 2004 |
| Cubic Construction N/West Ltd. | Construction | 2005 |
| Cubic Trading Limited | Construction | 2016 |
| Cubiv Ltd | Administrative & support | 2025 |
| Curious Antics Limited | Administrative & support | 2026 |
| Custom Deliveries Limited | Transport & logistics | 2002 |
| Cuttz Ltd | Wholesale & retail | 2024 |
| Cutwise Limited | Other services | 2013 |
| CVM Structural Engineers Ltd | Professional & scientific | 2023 |
| CW One Ltd | Arts & recreation | 2017 |
| CW Polo Ltd | Arts & recreation | 2024 |
| CW1 Crossfit Ltd | Arts & recreation | 2013 |
| CW2 Pressure Washing Ltd | Administrative & support | 2025 |
| Cwpp Limited | Real estate | 2025 |
| CWS Disposables Limited | Wholesale & retail | 2018 |
| CX Cafe Ltd | Hospitality | 2026 |
| Cyber OPS Global Limited | Education | 2009 |
| Cybermoves Ltd | Administrative & support | 2025 |
| Cyril Ezinwa Ltd | Health & social care | 2025 |
| Cyrossi Limited | Professional & scientific | 2012 |
| D & D Building Group Limited | Construction | 2025 |
| D & G Office Supplies Limited | Wholesale & retail | 2004 |
| D & P Transport Services Limited | Transport & logistics | 2021 |
| D & S Muir Limited | Agriculture & fishing | 2003 |
| D a Udall Accountancy & Taxation Services Limited | Professional & scientific | 2015 |
| D and B Couriers Ltd | Transport & logistics | 2023 |
| D Ashton Decorators Limited | Construction | 2003 |
| D Bees P S Ltd | Construction | 2023 |
| D C Express Logistics Ltd | Transport & logistics | 2026 |
| D H Jones and SON Limited | Agriculture & fishing | 2016 |
| D Sandiford Limited | Professional & scientific | 2016 |
| D T Rail Limited | Construction | 2018 |
| D Tomlinson Associates Ltd | Professional & scientific | 2009 |
| D Ward and Sons Agri Services Ltd | Other services | 2023 |
| D&E Trans Ltd | Transport & logistics | 2025 |
| D&J Harper Property Limited | Real estate | 2025 |
| D&J Property Cheshire Limited | Real estate | 2017 |
| D&L Auto Group Ltd | Wholesale & retail | 2023 |
| D&N Rentals Ltd | Real estate | 2018 |
| D.A.S.H Hot Tubs & Outdoor Inflatable Hire Ltd | Administrative & support | 2025 |
| D.G.Windows (Staffs) Ltd | Wholesale & retail | 2013 |
| D.L. Evans and SON (Building) Limited | Construction | 1988 |
| D16 Promoveo Developments Limited | Real estate | 2025 |
| D16 Promoveo Property Limited | Real estate | 2025 |
| D16PP Holdings Limited | Financial services | 2026 |
| D4 Facades and Interiors Limited | Manufacturing | 2022 |
| Da&M Ltd | Construction | 2026 |