| Daga's Buzzy Bee's Ltd | Health & social care | 2026 |
| Dainese (UK) Limited | Wholesale & retail | 1996 |
| Dairy Solutions Limited | Wholesale & retail | 2002 |
| Dairygold Food Ingredients (UK) Limited | Manufacturing | 1980 |
| Dairygold Holdings (UK) Limited | Manufacturing | 1993 |
| Damian Burdin Associates Ltd | Administrative & support | 2020 |
| DAMO91 Ltd | Transport & logistics | 2021 |
| DAN the Van Ltd | Transport & logistics | 2023 |
| Dancso Trans Ltd | Transport & logistics | 2024 |
| Danny Young Ltd | Information & communication | 2024 |
| Dannys KOI and Aquatics Ltd | Wholesale & retail | 2025 |
| Darin Recovery Limited | Transport & logistics | 2026 |
| Dariusz Statkiewicz Transport Ltd. | Transport & logistics | 2013 |
| Dark Barber Crew Ltd | Other services | 2026 |
| Darlington and Daughters | Manufacturing | 2007 |
| Darlington Associates Ltd | Professional & scientific | 2013 |
| Darlington Surveyors Ltd | Professional & scientific | 2019 |
| Darrell Baker Consulting Limited | Professional & scientific | 2015 |
| Darren Bell Group Ltd | Administrative & support | 2022 |
| Darshanth Ltd | Real estate | 2026 |
| Daski Ltd | Public administration | 2022 |
| Data Saint Limited | Information & communication | 2021 |
| Data Solutions Group Ltd | Administrative & support | 2019 |
| Data Talent Scout Ltd | Administrative & support | 2023 |
| Datum House (Crewe) LLP | | 2008 |
| Daunt Consulting Limited | Professional & scientific | 2025 |
| Dave Cooper Plumbing & Heating Services Limited | Construction | 2008 |
| Dave Meseck Consultancy Limited | Real estate | 2021 |
| Davenham Engineering Limited | Manufacturing | 2026 |
| David James Jewellers Ltd | Wholesale & retail | 2022 |
| David Kirk & Co. Ltd | Professional & scientific | 2010 |
| Davies Commercial Consulting Ltd | Professional & scientific | 2026 |
| Davoid Ltd | Wholesale & retail | 2023 |
| Daxperience Limited | Information & communication | 2024 |
| Daylight Farming Limited | Agriculture & fishing | 2012 |
| Days Animal Health Limited | Extraterritorial | 2003 |
| DBI Funding Ltd | Administrative & support | 2024 |
| DBI Holdings Ltd | Mining & quarrying | 2010 |
| DBI Logistics Limited | Administrative & support | 2020 |
| DBI Properties Ltd | Real estate | 2023 |
| DBI Transportation Limited | Administrative & support | 2021 |
| DBI Widnes Limited | Financial services | 2025 |
| Dbws Investments Limited | Administrative & support | 2020 |
| DC & SON Farm Ltd | Agriculture & fishing | 2021 |
| DC Events LLP | | 2026 |
| DC Technical Solutions (UK) Ltd | Construction | 2011 |
| DCA PUB Company Ltd | Hospitality | 2025 |
| Dcln Group Ltd | Professional & scientific | 2025 |
| DCM Change Consulting Limited | Professional & scientific | 2013 |
| DCS Communications Ltd | Information & communication | 2011 |
| DD Pubs & Leisure Ltd | Hospitality | 2023 |
| DDS Ropeworx Ltd | Construction | 2026 |
| DE Nada (UK) Limited | Professional & scientific | 2007 |
| DE Nada Homes Limited | Real estate | 2019 |
| Dead Drop Co Ltd | Wholesale & retail | 2025 |
| Deal Centre Ltd | Wholesale & retail | 2022 |
| Deansbrooke Limited | Other services | 2025 |
| Decoor Ltd | Wholesale & retail | 2026 |
| Decor Debonair Ltd | Wholesale & retail | 2021 |
| Deel World International Global Payroll Holdings Limited | Financial services | 2023 |
| Deel World International Global Payroll UK Limited | Financial services | 2023 |
| Deforce Services Ltd | Transport & logistics | 2025 |
| Delectrix Ltd | Construction | 2017 |
| Delegait Ltd | Information & communication | 2026 |
| Deliveringforyou Ltd | Transport & logistics | 2026 |
| Delivery DOT COM DDC Limited | Transport & logistics | 2026 |
| DELIVERYS4U Ltd | Transport & logistics | 2025 |
| Demokratia Strategies Limited | Information & communication | 2018 |
| Denisa Barbu Limited | Health & social care | 2018 |
| Denmor Building Limited | Construction | 2015 |
| Denstone Services Limited | Administrative & support | 2020 |
| Dents Inc Ltd. | Wholesale & retail | 2002 |
| Denver Sealants Ltd | Construction | 2014 |
| Desicon Domestic Services Limited | Construction | 2022 |
| Design & Service ES Limited | Professional & scientific | 2018 |
| Design Office UK Ltd | Manufacturing | 1993 |
| Design Solutions Architecture Limited | Professional & scientific | 2007 |
| Designs for Bathrooms Limited | Construction | 2005 |
| Dessert Masters Ltd | Hospitality | 2017 |
| Destination City Ltd | Hospitality | 2025 |
| Deva Strata Limited | Professional & scientific | 1988 |
| Devco Sales & Marketing Limited | Professional & scientific | 2000 |
| Dewie Skin Ltd | Other services | 2025 |
| DFL (Crewe) Limited | Construction | 2009 |
| DH and JC Mansfield Properties LLP | | 2008 |
| Diamond Agricultural and Industrial Buildings Ltd | Construction | 2010 |
| Diamond Clean Cheshire Limited | Administrative & support | 2025 |
| Diamond Electrical (Cheshire) Ltd | Construction | 2016 |
| Diamonds Valeting Ltd | Manufacturing | 2023 |
| Diana's Care Ltd | Health & social care | 2017 |
| Dickinson & Lucyk Limited | Professional & scientific | 2002 |
| Digawayuk Ltd | Construction | 2024 |
| Digiplex Ltd | Professional & scientific | 2023 |
| Digne Limited | Other services | 2024 |
| Dine With ME Ltd | Other services | 2010 |
| Dino’S Nursery and Preschool Limited | Education | 2023 |
| Dipova Transport Ltd | Transport & logistics | 2025 |
| Dirty Boys Ltd | Other services | 2026 |
| Discounted Cleaning Supplies Ltd | Wholesale & retail | 2011 |
| Discounted Cosmetics Limited | Wholesale & retail | 2014 |